Email this article Prognostic significance of mmp-1, mmp-3, and mthfr genetic polymorphism for evaluation of uterine leiomyoma and adenomyosis progression
- Authors: Morozova Е.В.1,2, Chukhlovin А.B.1,2, Kulagina N.V.1,2, Totolian А.А.1,2
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Affiliations:
- State Medical University named after acad. I.P. Pavlova
- Medical Academy of Postgraduate Education
- Issue: Vol 54, No 3 (2005)
- Pages: 55-59
- Section: Original study articles
- URL: https://journals.rcsi.science/jowd/article/view/83482
- DOI: https://doi.org/10.17816/JOWD83482
- ID: 83482
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Abstract
Carriage of hyperactive alleles of matrix metalloproteinase-1 (MMP-1) gene is associated with enhanced growth of various neoplasias in humans. When studying the frequency of promoter variants of MMP -1 and -3 genes in 170 patients with uterine leiomyoma, significant associations were revealed between low incidence of MMP-1 1G/1G genotype, high growth rates of leiomyoma, multifocal growth and more common adenomyosis development, thus presuming a protective role of MMP-1/1G homozygosity in the development of symptomatic myoma and adenomyosis and growth-promoting effect of the 2G allele. Hence, the promoter genotype of MMP-1 may be considered as possible genetic marker to predict clinical course of the uterine leiomyoma.
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##article.viewOnOriginalSite##About the authors
Е. В. Morozova
State Medical University named after acad. I.P. Pavlova; Medical Academy of Postgraduate Education
Author for correspondence.
Email: info@eco-vector.com
Scientific and Methodological Center for Molecular Medicine of the Ministry of Health of the Russian Federation
Russian Federation, Saint Petersburg; Saint PetersburgА. B. Chukhlovin
State Medical University named after acad. I.P. Pavlova; Medical Academy of Postgraduate Education
Email: info@eco-vector.com
Scientific and Methodological Center for Molecular Medicine of the Ministry of Health of the Russian Federation
Russian Federation, Saint Petersburg; Saint PetersburgN. V. Kulagina
State Medical University named after acad. I.P. Pavlova; Medical Academy of Postgraduate Education
Email: info@eco-vector.com
Scientific and Methodological Center for Molecular Medicine of the Ministry of Health of the Russian Federation
Russian Federation, Saint Petersburg; Saint PetersburgА. А. Totolian
State Medical University named after acad. I.P. Pavlova; Medical Academy of Postgraduate Education
Email: info@eco-vector.com
Scientific and Methodological Center for Molecular Medicine of the Ministry of Health of the Russian Federation
Russian Federation, Saint Petersburg; Saint PetersburgReferences
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