The contribution of polymorphism in VDR gene FОKI in the development of osteopenia in pregnancy

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Abstract

The study involved 89 postpartum women and 97 nonpregnant women aged 20 to 35 years. The results of a genetic test compared with the BMD. In parturients in the lumbar spine the highest IPC and the value of the Z-scores were in patients with genotype FF, and the lowest with the genotype ff. Patients with the heterozygous genotype were charac terized by intermediate values of the BMD and Z-scores in the lumbar spine. A similar results was observed in the proximal femur and the distal forearm. The results of the correlation analysis showed a moderate negative correlation between the ff genotype and the level of BMD in lumbar spine (r = –0,44; p < 0.05) and proximal femur (r = –0.37; p < 0.05).

About the authors

Olga S. Bibkova

I.P. Pavlov First St Petersburg State Medical University

Author for correspondence.
Email: sudakkova@yandex.ru

post-graduate student of Department of general practice

Russian Federation, 6/9, Lva Tolstogo street, St. Petersburg, 197089

Dmitriy S. Sudakov

North-Western State Medical University named after I.I. Mechnikov

Email: suddakovv@yandex.ru

assistant professor of the Department of obstetrics and gynecology

Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

Evdokia O. Bogdanova

I.P. Pavlov First St Petersburg State Medical University

Email: evdokia.bogdanova@gmail.com

researcher of the Laboratory of biochemical homeostasis Research institute of Nephrology

Russian Federation, 6/9, Lva Tolstogo street, St. Petersburg, 197089

Natalia L. Shaporova

I.P. Pavlov First St Petersburg State Medical University

Email: shapnl@mail.ru

professor of the Department of general practice

Russian Federation, 6/9, Lva Tolstogo street, St. Petersburg, 197089

Irina E. Zazerskaya

Federal Almazov North-West Medical Research Center

Email: zazera@mail.ru

deputy director for research activities of Institute of perinatology and pediatrics

Russian Federation, 2 Akkuratova str., Saint- Petersburg, 197341

Olga V. Galkina

I.P. Pavlov First St Petersburg State Medical University

Email: ovgalkina@mail.ru

head of the Laboratory of biochemical homeostasis Research institute of Nephrology

Russian Federation, 6/9, Lva Tolstogo street, St. Petersburg, 197089

Yulia R. Dymarskaya

North-Western State Medical University named after I.I. Mechnikov

Email: julia_dym@mail.ru

assistant professor of the Department of obstetrics and gynecology

Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

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Copyright (c) 2017 Bibkova O.S., Sudakov D.S., Bogdanova E.O., Shaporova N.L., Zazerskaya I.E., Galkina O.V., Dymarskaya Y.R.

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