Morphological features of the placenta in obese women
- Authors: Seryogina D.S.1, Sosnina A.K.1, Tral T.G.1, Tolibova G.K.1, Mozgovaya E.V.1,2
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Affiliations:
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- Saint Petersburg State University
- Issue: Vol 69, No 6 (2020)
- Pages: 91-98
- Section: Original Research
- URL: https://journals.rcsi.science/jowd/article/view/59243
- DOI: https://doi.org/10.17816/JOWD69691-98
- ID: 59243
Cite item
Abstract
Hypothesis/Aims of study. Obesity and severe chronic somatic pathology in a woman leads to a rapid depletion of compensatory and adaptive reserves of the placenta and to the progression of circulatory and dystrophic changes, which causes intrauterine growth retardation and reduces the likelihood of a favorable course of pregnancy and childbirth. The aim of this study was to assess the morphological features of the vascular component of placental villi in obese women.
Study design, materials and methods. Histological and immunohistochemical studies were conducted on 41 placentas from obese patients with and without gestational diabetes mellitus and from healthy patients, endothelial marker CD34+ expression being assessed in chorionic villi.
Results. In obese patients, chronic placental insufficiency is presented in most cases as a dissociated form with persistence of not only mature but also immature villi, which indicates early structural pathology of the placenta.
Conclusion. Obesity in women contributes to more frequent chronic placental insufficiency with severe circulatory disorders and varying degrees of severity of compensatory and adaptive changes.
Keywords
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##article.viewOnOriginalSite##About the authors
Darya S. Seryogina
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Author for correspondence.
Email: dunyashadasha00@gmail.com
ORCID iD: 0000-0002-6496-586X
SPIN-code: 2852-3281
MD, Postgraduate Student. The Delivery Department
Russian Federation, Saint PetersburgAlexandra K. Sosnina
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: aleksandrasosnina@bk.ru
ORCID iD: 0000-0002-9353-9333
MD, PhD
Russian Federation, Saint PetersburgTatyana G. Tral
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: ttg.tral@yandex.ru
ORCID iD: 0000-0001-8948-4811
Scopus Author ID: 37666260400
MD, PhD, Head of the Pathology Department
Russian Federation, Saint PetersburgGulrukhsor Kh. Tolibova
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: gulyatolibova@yandex.ru
ORCID iD: 0000-0002-6216-6220
SPIN-code: 7544-4825
Scopus Author ID: 23111355700
MD, PhD, DSci (Medicine), Leading Researcher, Head of the Laboratory of Immunohistochemistry
Russian Federation, Saint PetersburgElena V. Mozgovaya
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State University
Email: elmozg@mail.ru
ORCID iD: 0000-0002-6460-6816
SPIN-code: 5622-5674
MD, PhD, DSci (Medicine), Head of the Department of Obstetrics and Perinatology; Professor. The Department of Obstetrics, Gynecology, and Reproductive Sciences, the Faculty of Medicine
Russian Federation, Saint PetersburgReferences
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