Morphological substantiation of pathogenetic therapyof external genital endometriosis

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Abstract

With the help of morphological study examined endometrioid heterotopias and eutopic endometrium in external genital endometriosis. Histological examination of surgical specimens of endometrial cancer were detected in endometrioid heterotopia, in eutopic endometrium occurred glandular-cystic hyperplasia of the proliferative and secretory type. Have been identified in the heterotopias expressed angiomatosis in patients with III-IV stages of endometriosis. It is proved that inflammatory changes in endometrioid heterotopias more pronounced with stage I-II stages of endometriosis, whereas hyalinosis sclerosis and how the outcomes of the process prevalent in patients with stage III-IV. The difference parameters in ectopic and eutopic endometrium shows marked morphological heterogeneity of both nuclear and cytoplasmic structures. Morphological changes in the heterotopias are intended to justify Dienogest (2 mg) for the treatment of external genital endometriosis.

About the authors

Irina V Markar’yan

Rostov Research Institute of Obstetrics and Pediatrics, the Ministry of Health of Russia

Author for correspondence.
Email: markaryan@mail.ru
MD, obstetrician-gynecologist Russian Federation

Natalia V Yermolova

Rostov Research Institute of Obstetrics and Pediatrics, the Ministry of Health of Russia

Email: ermolova@mail.ru
MD, deputy. Director for Science, Head of gynecology department Russian Federation

Nina A Drukker

Rostov Research Institute of Obstetrics and Pediatrics, the Ministry of Health of Russia

Email: drukker@mail.ru
Sc.D., Chief Scientific Officer Russian Federation

Vladimir Y Mazhugin

Rostov Research Institute of Obstetrics and Pediatrics, the Ministry of Health of Russia

Email: mazhugin@gmail.com
doctor of the highest category, Head of the Department of pathologic Russian Federation

Alexander N Rymasheuski

FGBOU IN “RostGMU” the Ministry of Health of Russia

Email: ryimashevski@list.ru
MD, Head of the Department of Obstetrics and Gynecology No 1 Russian Federation

Sofia A Trushina

FGBOU IN “RostGMU” the Ministry of Health of Russia

Email: trushina@mail.ru
graduate student Russian Federation

References

  1. Адамян Л.В., Сонова М.М., Тихонова Е.С., Антонова С.О. Медицинские и социальные аспекты генитального эндометриоза // Проблемы репродукции. – 2011. – № 6. – С. 78–81. [Adamjan LV, Sonova MM, Tihonova ES, Antonova SO. Medicinskie i social’nye aspekty genital’nogo jendometrioza. Problemy reprodukcii. 2011;(6):78-81. (In Russ.)]
  2. Cornillie FJ, Oosterlynck D, Lauweryns JM, Koninckx PR. Deeply infiltrating pelvic endometriosis: histology and clinical significance. Fertil Steril. 1990;53(6):978-83. doi: 10.1016/S0015-0282(16)53570-5.
  3. Сидорова И.С., Коган Е.А., Унанян А.Л. Эндометриоз тела матки и яичников. – М.: ММА, 2007. – 30 с. [Sidorova IS, Kogan EA, Unanjan AL. Jendometrioz tela matki i jaichnikov. Moscow: MMA; 2007. (In Russ.)]
  4. Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389-98. doi: 10.1056/NEJMcp1000274.

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Copyright (c) 2016 Markar’yan I.V., Yermolova N.V., Drukker N.A., Mazhugin V.Y., Rymasheuski A.N., Trushina S.A.

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