Current feasibilities of early ovarian cancer detection

Cover Page


Cite item

Full Text

Abstract

We analyzed results of laparoscopic surgical treatment of 349 patients with ovarian tumors. Before surgery besides standard examination ultrasonography of pelvis and Ca-125 estimation was performed. After comparing of preoperative diagnosis with histopatological report was identified low sensitivity and specificity of ultrasonography and Ca-125 for assessment of tumor malignancy potential (32,35 %, 31,82 % and 72,55 %, 68,36 % respectively). It was concluded that nowadays the only method of early ovarian cancer detection is surgical treatment of patients with ovarian tumors, who have ultrasonography malignancy markers and increased Ca-125 level.

About the authors

Anzhella S Khadzhimba

Research-Practical Center of Specialized Kinds of Medical Care (oncologic)

Email: Khadzhimba@gmail.com
physician oncologist of gynecologic oncologic department

References

  1. Bernard W, Stewart CP, ed. World Cancer Report. N.Y.; 2014.
  2. Каприн А.Д., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2013 году (заболеваемость и смертность). - М., 2015 [Kaprin AD, Starinskij VV, Petrova GV. Malignant neoplasm in Russia in 2013 (morbidity and mortality). Moscow; 2015.]
  3. Бреусенко В.Г., Соломатина А.А., Краснова И.А., Крюченкова М.Е. Ультразвуковое исследование как скрининг-метод диагностики патологии яичников у женщин периода постменопаузы // Вестник Российской ассоциации акушеров-гинекологов. - 1996. - № 1. - С. 81-83. [Breusenko VG, Solomatina AA, Krasnova IA, Krjuchenkova ME. Ultrasound examination as a screening method for the diagnosis of ovarian pathology in women postmenopausal. Vestnik Rossijskoj associacii akusherov-ginekologov. 1996;1:81-83.]
  4. Кузнецова Е.П., Серебренникова К.Г. Современные методы диагностики опухолевидных образований и доброкачественных опухолей яичников. Med Sci Fundament Res. - 2010. - № 11. - С. 78. [Kuznecova EP, Serebrennikova KG. Modern methods of diagnosis and tumor-like formations of benign ovarian tumors. Med Sci Fundament Res. 2010;11:78.]
  5. Кулаков В.И., Демидов В.Н., Гатауллина Р.Г., и др. Значение применения эхографии перед проведением лапароскопии // Акушерство и гинекология. - 1996. - № 5. - С. 15-19. [Kulakov VI, Demidov VN, Gataullina RG, et al. The value of the application of ultrasound prior to laparoscopy. Akusherstvo i ginekologija. 1996;5:15-19.]
  6. Никогосян C.O., Кузнецов В.В. Современная диагностика рака яичников // Российский онкологический журнал. - 2013. - № 5. - С. 52-56. [Nikogosjan CO, Kuznecov VV. Current diagnosis of ovarian cancer. Rossijskij onkologicheskij zhurnal. 2013;5:52-56.]
  7. Ghezzi F, et al. Laparoscopy staging of early ovarian cancer: our experience and review of the literature. Int J Gynecol Cancer. 2009;19(Suppl. 2):S 7-S 13. doi: 10.1111/IGC.0b013e3181bf82f3.
  8. Jacobs I, Davies AP, Bridges J, et al. Prevalense screening for ovarian cancer in postmenopausal women by CA 125 measurement and ultrasonography. Br Med J. 1993;306:1030. doi: 10.1136/bmj.306.6884.1030.
  9. Park JY, et al. Laparoscopic and laparotomic staging in stage I epithelial ovarian cancer: a comparison of feasibility and safety. Int J Gynecol Cancer. 2008;18(6):1202-9. doi: 10.1111/j.1525-1438.2008.01190.x.
  10. Rosen DG, Wang L, Atkinson JN, et al. Potential markers that complement expression of CA-125 in epithelial ovarian cancer. Gynecol Oncol. 2005;99:267-77. doi: 10.1016/j.ygyno.2005.06.040.
  11. Rustin GJS, Nelstrop AE, Bentzen SM, et al. Use of tumor marcers in monitoring the course of ovarian cancer. Ann Oncol. 1999;10(suppl.1):21-27. doi: 10.1023/A:1008351216605.
  12. Sturgeon CM, Duffy MJ, Stenman UH, et al. National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. Clin Chem. 2008;54: e11-79. doi: 10.1373/clinchem.2008.105601.
  13. Цыпурдеева А.А., Урманчеева А.Ф., Зельдович Д.Р. Роль лапароскопии в диагностике и лечении злокачественных опухолей яичников // Вопросы онкологии. - 2000. - № 1. - С. 76-79. [Cypurdeeva AA, Urmancheeva AF, Zel’dovich DR. Role of laparoscopy in the diagnosis and treatment of malignant ovarian tumors. Voprosy onkologii. 2000;1:76-79.]
  14. Gleeson NC, Nicosia SV, Mark JE, et al. Abdominal wall metastases from ovarian cancer after laparoscopy. Amer J Obst Gynecol. 1993;169(3):522-3. doi: 10.1016/0002-9378(93)90611-L.
  15. Hubens G, Pauwels M, Hubens A, et al. The influence of a pneumoperitoneum on peritoneal implantation of free intraperitoneal cancer cells. Surg Endosc. 1996;10:809-812. doi: 10.1007/BF00189539.
  16. Iwanaka T, Arya G, Ziegler MM. Mechanism and prevention of port-site tumour recurrence after laparoscopy in a murine model. J Pediatric Surg. 1998;33:457-61. doi: 10.1016/S 0022-3468(98)90088-4.
  17. Lee M, et al. Comparisons of surgical outcomes, complications, and costs between laparotomy and laparoscopy in early-stage ovarian cancer. Int J Gynecol Cancer. 2011; 21(2):251-6. doi: 10.1097/IGC.0b013e318208c71c.
  18. Liu CS, Nagarsheth NP, Nezhat FR. Laparoscopy and ovarian cancer: a paradigm change in the management of ovarian cancer? J Minim Invasive Gynecol. 2009;16(3):250-62. doi: 10.1016/j.jmig.2009.01.007. Epub 2009 Mar 24. doi: 10.1016/j.jmig.2009.01.007.
  19. Spinelli P, Pilotti S, Luini A, et al. Laparoscopy combined with peritoneal cytology in staging and restaging ovarian carcinoma. Tumori. 1979;65(5):601-10.
  20. Tseng LNL, Berends FJ, Wittich P, et al. Port site metastases. Impact of local tisue trauma and gas leakage. Surg Endosc. 1998;12:1377-80. doi: 10.1007/s004649900862.

Copyright (c) 2016 Khadzhimba A.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies