Hemostasis in pregnant women with gestational diabetes mellitus

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Abstract

Been analyzed and studied the characteristics of hemostasis in pregnant women with gestational diabetes mellitus. Found that for women with disorders of carbohydrate metabolism characte-rized by increased activity of procoagulant, vascular-platelet hemostasis, and decreased activity of fibrinolityc system. It is shown that the violations of the haemostatic system is directly dependent on the degree of compensation of carbohydrate metabolism and require adequate correction of glycemia. Thus, GDM is an important predictor of hemostatic disorders and possible venous thromboembolism in pregnancy.

About the authors

Roman Viktorovich Kapustin

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: Kapustin.Roman@gmail.com
postgraduate, Department of pathology of pregnancy

Olga Nikolayevna Arzhanova

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: arjanova_olga@mail.ru
MD, Professor, Head of the Department of Pathology of pregnancy

Tatyana Nikolayevna Shlyakhtenko

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: Tatnicshe@mail.ru
Phd, Senior Researcher, Laboratory of immunology

Tatyana Ivanovna Oparina

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: oparinat@mail.ru
Phd, Senior Researcher, Laboratory of biochemistry

Yevgeniy Konstantinovich Komarov

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: iagmail@ott.ru
MD, Main Senior Researcher, Department of Pathology of pregnancy

References

  1. Айламазян Э. К., Петрищев Н. Н., Мозговая Е. В. Состояние тромбоцитарно-сосудистого звена гемостаза у больных инсулинзависимым сахарным диабетом, имеющих сосудистые осложнения, во время беременности // Акушерство и гинекология. — 2000. — № 3. — С. 35–40.
  2. Зайнулина М. С., Мозговая Е. В., Ниаури Д. А. Диагностическое значение эндотелиограммы у беременных с поздним гестозом и сахарным диабетом // Журнал акушерства и женских болезней. — 1999. — № 3. — С. 22–24.
  3. Краснопольский В. И., Мельников А. П., Бокарев И. Н. Современные проблемы нарушений гемокоагуляции в акушерстве // Российский вестник акушера-гинеколога. — 2010. — № 2. — С. 20–27.
  4. Мембранные рецепторы тромбоцитов: функции и полиморфизм / Воронина Е. Н., Филипенко М. Л., Сергеевичев Д. С., Пикалов И. В. // Вестник ВОГиС. — 2006. — T 10, № 3. — P. 553–564.
  5. Тромбофилии в акушерской практике: методические рекомендации / М. С. Зайнулина, Е. А. Корнюшина, А. С. Глотов [и др.]; ред. Э. К. Айламазян, В. С. Баранов. — СПб.: Изд-во Н-Л, 2009. — 56 с.
  6. Alterations of platelet biochemical and functional properties in newly diagnosed type 1 diabetes: a role in cardiovascular risk? / Vignini A. [et al.] // Diabetes Metab. Res. Rev. — 2011. — Vol. 27. — P. 277–285.
  7. Alterations of sympathetic nervous system, coagulation and platelet function in gestational diabetes / Pöyhönen-Alho M., Joutsi-Korhonen L., Lassila R., Kaaja R. // Blood Coagul. Fibrinolysis. — 2012. — Vol. 23. — P. 508–513.
  8. Aslan B., Eren N., Cigerly S. Evaluation of protein C antigen, protein C activity and trombomodulin levels in type 2 diabetic patients // Turk. J. Med. Sci. — 2005. — Vol. 35. — P. 305–310.
  9. Carr M. E. Diabetes mellitus. A Hypercoagulable state // J. Diabetes its Complications. — 2001. — Vol. 15, N 1. — P. 44–54.
  10. Ceriello A., Quatraro A., Dello Russo P. Protein C deficiency in diabetes patients // Thromb Haemost. — 1990. — Vol. 64. — P. 104–107.
  11. Cheung N. W., Byth K. The population health significance of gestational diabetes // Diabetes Care. — 2003. — Vol. 26. — P. 2005–2009.
  12. Coagulation and fibrinolysis parameters in normal pregnancy and in gestational diabetes / Bellart J. [et al.] // Am. J. Perinatol. — 1998. — Vol. 15. — P. 479–486.
  13. Diabetes mellitus and risk of venous thromboembolism /Stein P. D., Goldman J., Matta F., Yaekoub A. Y. // Am. J. Med. Sci. — 2009. — Vol. 337. — P. 259–264.
  14. Effects of magnesium on platelet aggregation and adhesion: magnesium modulates surface expression of glycoproteins on platelets in vitro and ex vivo / Gawaz M., Ott I., Reininger A. J., Neumann F. J. // J. Thrombosis Haemostasis. — 1994. — Vol. 72. — P. 912–918.
  15. Elevated plasma homocysteine levels in gestational diabetes mellitus / Tarim E. [et al.] // Acta Obstet. Gynecol. Scand. — 2004. — Vol. 83, N 6. — P. 543–547.
  16. Factors predisposing to preeclampsia in women with gestational diabetes / Barden A., Singh R., Walters B. N., Ritchie J. // J. Hypertens. — 2004. — Vol. 22. — P. 2371–2378.
  17. Fibrinogen binding and ADP-induced aggregation in platelets from diabetic subjects / Leet H., Paton R. C., Passa P., Caen J. P. // Thrombosis Research. — 1981. — Vol. 24. — P. 143–150.
  18. Fibrinolytic dysfunction in insulin-resistant women with previous gestational diabetes / Farhan S. [et al.] // Eur. J. Clin. Invest. — 2006. — Vol. 36. — P. 345–352.
  19. Gabazza E., Takeya H., Deguchi H. Protein C activation in NIDDM patients // Diabetologia. — 1996. — Vol. 39, N 12. — P. 1455–1461.
  20. Gestational diabetes affects platelet behaviour through modified oxidative radical metabolism / Mazzanti L. [et al.] // Diabet Med. — 2004. — Vol. 21. — P. 68–72.
  21. Gray R., Panahloo A., Mohamed-Ali V. Proinsulin-like molecules and plasminogen activator inhibitor type 1 (PAI-1) activity in diabetic and non-diabetic subjects with and without myocardial infarction // Atherosclerosis. — 1997. — Vol. 130. — P. 171–178.
  22. Greer I. A. Risk factors and diagnosis of VTE in pregnancy // Thromb Res. — 2007. — Vol. 119. — P. 1–8.
  23. Haemostatic and cytokine changes in gestational diabetes mellitus / Abdel Galil [et al.] // Gynecological Endocrinology. — 2011. — Vol. 27, N 5. — P. 356–360.
  24. Hemostasis and levels of cytoadhesion molecules in gestational diabetes / Bendl J., Kvasnicka J., Umlaufova A., Kvasnicka J., Zivny J. // Česka Gynekol. — 1999. — Vol. 64. — P. 83–86.
  25. Hemostatic abnormalities in diabetes: hematology for the cardiologist / Lakhani M., Kokolis S., Cavusoglu E., Soff G. // Cardiovascular Disease and Diabetes / Eds Clark L. T., McFarlane S. I. — N. Y.: McGraw-Hill Professional, 2006. — P. 402–455.
  26. Impaired platelet function in neonates born to mothers with diabetes or hypertension during pregnancy / Strauss T. [et al.] // Klin. Padiatr. — 2010. — Vol. 222. — P. 154–157.
  27. Increased platelet thromboxane synthesis in diabetes mellitus / Halushka P. V., Rogers R. C., Loadholt C. B., Colwell J. A. // J. Laboratory Clinical Medicine. — 1981. — Vol. 97. — P. 87–96.
  28. Increased tissue factor pathway inhibitor (TFPI) and coagulation in patients with insulin-dependent diabetes mellitus /Leurs P. B., Van Oerler R., Wolffenbuttel B. H. R., Hamulyak K. // Thrombosis and haemostasis. — 1997. — Vol. 77. — P. 472–476.
  29. Insulin sensitivity and hemostatic factors in clinically healthy 58-year old men / Agewall S., Bokemark L., Wikstrand J., Lindahl A., Fagerberg B. // Thrombosis and haemostasis. — 2000. — Vol. 84. — P. 571–575.
  30. Jacobsen A. F., Skjeldestad F. E., Sandset P. M. Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium: a register-based case-control study // Am. J. Obstet. Gynecol. — 2008. — Vol. 198. — P. 233–237.
  31. Jokl R., Colwell J. A. Arterial thrombosis and atherosclerosis in diabetes // Diabetes Metabolism Reviews. — 1997. — Vol. 5. — P.1–15.
  32. Kozek E., Katra B., Malecri M. Visceral obesity and haemostatic profile in patient with type 2 diabetes: the effect of gender and metabolic compensation // Rev. Diabet. Stud. — 2004. — Vol. 3. — P. 122–128.
  33. Marik P. E., Plante L. A. Venous thromboembolic disease and pregnancy // N. Engl. J. Med. — 2008. — Vol. 359. — P. 2025–2033.
  34. Pandolfi A., Giaccari A., Cilli C. Acute hyperglycemia decrease plasma fibrinolytic activity and increase PAI –1 // Acta Diabetol. — 2001. — Vol. 38. — P. 71–76.
  35. Platelet dysfunction in type 2 diabetes / Vinik A. I., Erbas T., Park T. S., Nolan R., Pittenger G. L. // Diabets Care. — 2001. — Vol. 24. — P. 1476–1485.
  36. Platelet eNOS activity is reduced in patients with IDDM and NIDDM / Martina V. [et al.] // J. Thrombosis Haemostasis. — 1998. — Vol.79. — P. 520–522.
  37. Platelet functions during continuous insulin infusion treatment in insulin-dependent diabetic patients / Mayfield R. K., Halushka P. V., Wohltmann H. J., Lopes-Virella M. // Diabetes. — 1985. — Vol. 34. — P. 1127–1133.
  38. Risk factors of deep vein thrombosis and pulmonary embolism in Korean / Moon H. J. [et al.] // Korean Circ. J. — 2005. — Vol.35. — P. 474–479.
  39. Saito M., Kumabashiri I., Jokaji H. The levels of protein C and protein S in plasma in patients with type 2 diabetes mellitus // Thromb. Res. — 1988. — Vol. 52. — P. 479–486.
  40. The cardiovascular risk factor plasminogen activator inhibitor type 1 is related to insulin-resistance / Potter van Loon B.[et al.] // Metabolism. — 1993. — Vol. 42, N 8. — P. 945–949.
  41. Total plasma homocysteine correlates in women with gestational diabetes / Idzior-Waluś B. [et al.] // Arch. Gynecol. Obstet. — 2008. — Vol. 278, N 4. — P. 309–313.
  42. Trial of repeated low-dose aspirin in diabetic angiopathy / DiMinno G., Silver M. J., Cerbone A. M., Murphy S. // Blood. — 1986. — Vol. 68. — P. 886–891.
  43. Tschoepe D., Rauch U., Schwippert B. Platelet-leukocyte-cross-talk in diabetes mellitus // Hormone Metabolic Research. — 1997. — Vol. 29. — P. 631–635.
  44. Value of coagulation function and fibrinolytic system assessment in patients with gestational diabetes mellitus / Liu B. Y. [et al.] // Nan Fang Yi Ke Da Xue Xue Bao. — 2007. — Vol. 27, N 1. — P. 35–37.
  45. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality / James A. H., Jamison M. G., Brancazio L. R., Myers E. R. // Am. J. Obstet. Gynecol. — 2006. — Vol.194. — P.1311–1315.

Copyright (c) 2013 Kapustin R.V., Arzhanova O.N., Shlyakhtenko T.N., Oparina T.I., Komarov Y.K.

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