Hyperhomocysteinemia in miscarriage: biochemical and genetic aspects

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Abstract

Elevated levels of homocysteine in the blood is an important marker of the occurrence of various obstetric pathology. As a result of hyperhomocysteinemia impairs processes of microcirculation in the placenta. This in turn can lead to defects of implantation resulting in miscarriage. One of the factors contributing to the increase in the level of homocysteine in the blood is a hereditary predisposition. The purpose of this study is to analyze the influence of gender, age, number of spontaneous miscarriages, the genotype of MTHFR and MTRR genes with folate cycle homocysteine in the blood, the couple with miscarriages.

About the authors

Olesya Nikolaevna Bespalova

D. O. Ott Research Institute of Obstetrics and Gynecology, RAMS

Email: shiggerra@mail.ru
MD, PhD, DMSc, Leading researcher of the 1st obstetric pregnancy pathology department

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Copyright (c) 2015 Bespalova O.N.

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