Email this article Anamnestic and microbiological predictors of miscarriage
- Authors: Sinyakova A.A.1, Shipitsyna E.V.1,2, Budilovskaya O.V.1,2, Bolotskikh V.M.1,2,3, Savicheva A.M.1,2
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Affiliations:
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- Saint Petersburg State Pediatric Medical University
- Saint Petersburg State University
- Issue: Vol 68, No 2 (2019)
- Pages: 59-70
- Section: Original Research
- URL: https://journals.rcsi.science/jowd/article/view/12946
- DOI: https://doi.org/10.17816/JOWD68259-70
- ID: 12946
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Abstract
Hypothesis/aims of study. Miscarriage is a significant medical and social problem. The etiology of pregnancy losses is diverse and depends on many factors. It is believed that dysbiotic disorders of the vagina are one of the main causes of this pathology. While the etiopathogenesis of miscarriage is actively studied, many questions still remain open. The aim of the study was to investigate anamnestic and microbiological predictor factors of miscarriage.
Study design, materials, and methods. In a prospective cohort study, 159 pregnant women were examined in the first trimester of pregnancy: the anamnesis, course of pregnancy, vaginal microflora, and present pregnancy outcome were studied. The vaginal microflora was analyzed using microscopic, bacteriological and quantitative real-time PCR methods. Depending on the present pregnancy outcome, the patients were divided into two groups: those delivered at term and women with early and late miscarriage. The analysis of predictors of miscarriage of the ongoing pregnancy was performed depending on the period of delivery.
Results. The rate of miscarriage in women was 13%. The independent predictors of early miscarriage were chronic endometritis (OR 10.54; 95% CI 2.54 to 43.64), the dominance of Lactobacillus iners in the vaginal microflora (OR 8.52; 95% CI 2.07 to 35.05), and the prevalence of non-Lactobacillus species in microscopy of vaginal preparations (OR 4.50; 95% CI 1.02 to 19.69). The dominance of Lactobacillus crispatus was a significant protective factor of late miscarriage (OR 0.20; 95% CI 0.04 to 0.99).
Conclusion. The undertaken analysis revealed significant associations of a number of anamnestic and microbiological predictor factors with miscarriage, which will enable to substantiate approaches for predicting pregnancy outcomes at different gestational age and to develop methods of pre-conception care and treatment in women with different risk of miscarriage.
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##article.viewOnOriginalSite##About the authors
Anna A. Sinyakova
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Author for correspondence.
Email: annakizeeva@yandex.ru
Post-Graduate Student
Russian Federation, Saint PetersburgElena V. Shipitsyna
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University
Email: shipitsyna@inbox.ru
PhD, DSci (Biology), Leading Researcher. The Laboratory of Microbiology; Professor. The Department of Clinical Laboratory Diagnostics, the Faculty of Postgraduate and Additional Professional Education
Russian Federation, Saint PetersburgOlga V. Budilovskaya
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University
Email: o.budilovskaya@gmail.com
Researcher. The Laboratory of Microbiology; Assistant. The Department of Clinical Laboratory Diagnostics, the Faculty of Postgraduate and Additional Professional Education
Russian Federation, Saint PetersburgVyacheslav M. Bolotskikh
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University; Saint Petersburg State University
Email: iagmail@ott.ru
MD, PhD, DSci (Medicine), Deputy Director for Clinical Care; Associate Professor; Professor. The Department of Obstetrics, Gynecology, and Reproductive Sciences, Medical Faculty
Russian Federation, Saint PetersburgAlevtina M. Savicheva
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; Saint Petersburg State Pediatric Medical University
Email: savitcheva@mail.ru
MD, PhD, DSci (Medicine), Professor, Honoured Scholar of the Russian Federation, the Head of the Laboratory of Microbiology; the Head of the Department of Clinical Laboratory Diagnostics. The Faculty of Postgraduate and Additional Professional Education
Russian Federation, Saint PetersburgReferences
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