Email this article Clinical value of determination of markers of a thrombophylia at patients with the complicated pregnancy in the anamnesis
- Authors: Andreeva M.D.1
-
Affiliations:
- Kuban state medical university
- Issue: Vol 64, No 2 (2015)
- Pages: 13-17
- Section: Articles
- URL: https://journals.rcsi.science/jowd/article/view/1257
- DOI: https://doi.org/10.17816/JOWD64213-17
- ID: 1257
Cite item
Full Text
Abstract
The results of the survey of 214 patients with the complicated pregnancy (a preeclampsia, a premature detachment of placenta, antenatal fetal death, miscarriage) in the anamnesis are presented in the article. We determined the level of molecular markers of a thrombophilia (TAT, D-dimer) and aggregation activity of platelets and carried out antithrombotic therapy to these women. It is shown that 47,7 % of such nonpregnant women and pregnant early terms have the high level of D-dimer, TAT - 46,7 %, aggregation activity of platelets - 52,6 %. Determination of the increased levels of molecular markers of a thrombophilia is the indication to application the antithrombotic therapy and allow to control efficiency of this therapy.
Full Text
##article.viewOnOriginalSite##About the authors
Margarita Darchoevna Andreeva
Kuban state medical university
Email: andreeva_md@mail.ru
Phd, Associate Professor, department of obstetrics, gynecology and perinatology, Faculty of advanced training and professional retraining of specialists
References
- Самбурова Н. В. Клиническое значение контроля маркеров активации свертывания крови при проведении противотромботической терапии у беременных, рожениц и родильниц с тромбофилией: дис… канд. мед. наук. М. 2008; 132 с.
- Тромбогеморрагические осложнения в акушерско-гинекологической практике: Руководство для врачей. Под ред. А. Д. Макацария. М. 2011; 1056 с.
- Kovac M., Mitic G. et al. Thrombophilia in women with pregnancy-associated complications: fetal loss and pregnancy-related venous thromboembolism. Gynecol. Obstet. Invest. 2010; 69 (4): 233-8.
- Lykke J. A., Bare L. A., Olsen J. et al. Thrombophilias and adverse pregnancy outcomes: results from the Danish National Birth Cohort. J. Thromb. Haemost. 2012; 10 (7): 1320-5.
- Pabinger I. Thrombophilia and its impact on pregnancy. Thromb Res. 2009; 123 (3): 16-21.
- Rodger M. A. An update on thrombophilia and placenta mediated pregnancy complications: What should we tell our patients? Thromb. Res. 2013; 131 (1): 25-7.
