The role of growth factors in the pathogenesis of endometriosis

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Abstract

Endometriosis is a chronic inflammatory hormone-dependent disease characterized by abnormal proliferation in the endometrium, nerves, blood vessels, fibroblasts, etc. and accompanied by immunological disorders. Growth factors are an important part of the mechanisms that underlie intercellular communication, auto- and paracrine regulation. This literature review presents data on abnormal expression of growth factors in patients with endometriosis, relationship of growth factors and hormonal status in normal and endometrial tissues, and the supposed role of growth factors in the pathogenesis of the disease.

About the authors

Margarita S. Florova

The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott

Author for correspondence.
Email: m.yarmolinskaya@gmail.com

MD, Post-Graduate Student

Russian Federation, Saint Petersburg

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2. Fig. 1. Regulation of cell cycle by growth factors: G1 — Gap 1; G2 — Gap 2; M — mitosis; S — DNA synthesis

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