Bacterial DNA damage effectors in host cells

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Abstract

The microbiota has a significant, and sometimes decisive, effect on the host's homeostasis. The results of recent metagenomic studies confirm the importance of microbiota in maintaining health or its impact on the development of acute, chronic and neoplastic diseases. One of the important aspects of microbiota exposure is the ability of many bacterial species to induce mutations or modulate a mutation process in the cells of the host organism. This review summarizes the main experimental data revealing various mechanisms of genotoxic action of a bacterial microbiota, including direct damage to the DNA structure, induction of oxidative stress, delay in replication, and a decrease in repair efficiency. It is emphasized that bacteria use different strategies to ensure their own survival and replication, including. by suppressing the repair of host cell DNA, by promoting the survival of infected cells, despite the presence of DNA damage therein.

About the authors

Vladimir G. Druzhinin

Kemerovo State University; Federal Research Center of Coal and Coal Chemistry of Siberian Branch of RAS

Author for correspondence.
Email: druzhinin_vladim@mail.ru
ORCID iD: 0000-0002-5534-2062
SPIN-code: 6277-4704

Sci. Doctor, Professor, Head, Department of Genetics

Russian Federation, 6, Krasnaya street, Kemerovo, 650000; 18, Sovetsky pr., Kemerovo, 650000

Elizaveta D. Baranova

Kemerovo State University

Email: laveivana@mail.ru
ORCID iD: 0000-0001-9503-8500

Bachelor Student, Department of Genetics

Russian Federation, 6, Krasnaya street, Kemerovo, 650000

Vladislav Yu. Buslaev

Kemerovo State University

Email: vladislasbus2358@yandex.ru

Master Student, Department of Genetics

Russian Federation, 6, Krasnaya street, Kemerovo, 650000

Lyudmila V. Matskova

Kemerovo State University; Karolinska Institute

Email: liudmila.matskova@ki.se
SPIN-code: 4756-7437

Scientific Researcher, Department of Bionanotechnology; Department of Microbiology and Tumor Biology

Russian Federation, 6, Krasnaya street, Kemerovo, 650000; Stockholm, Sweden

Alina V. Tolstikova

Kemerovo State University

Email: tolstikova.alina@inbox.ru

Postgraduate Student, Department of Genetics

Russian Federation, 6, Krasnay street, Kemerovo, 650000

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Copyright (c) 2018 Druzhinin V.G., Baranova E.D., Buslaev V.Y., Matskova L.V., Tolstikova A.V.

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