PRION PROTEIN AND AMYLOID BETA PEPTIDE INTERACT IN THE YEAST SACCHAROMYCES CEREVISIAE


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Abstract

SUMMARY: The possibility of interaction between Prion Protein and amyloid beta peptide in living cells of yeast Saccharomyces cerevisiae have been investigated by fluorescence 3D microscopy. Using the FR ET technique, it was shown that amyloid beta peptide and PrP interact in yeast cells. In the future, the yeast model can be used for investigation of the fine mechanisms of this interaction by fluorescence microscopy.

About the authors

Aleksander A. Rubel

Saint-Petersburg State University; St. Petersburg Branch of N. I. Vavilov Institute of General Genetics

Author for correspondence.
Email: arubel@mail.ru

Ph.D., senior researcher

Russian Federation, 7/9, Universitetskaya nab., St.Petersburg, 199034; St.Petersburg

Viktoria V. Korzhova

Saint-Petersburg State University

Email: arubel@mail.ru

student

Russian Federation, 7/9, Universitetskaya nab., St.Petersburg, 199034

Alsu F. Saifitdinova

Saint-Petersburg State University

Email: saifitdinova@mail.ru

Ph.D., senior researcher

Russian Federation, 7/9, Universitetskaya nab., St.Petersburg, 199034

Kirill S. Antonez

Saint-Petersburg State University

Email: saifitdinova@mail.ru

student

Russian Federation, 7/9, Universitetskaya nab., St.Petersburg, 199034

Sergey G. Inge-Vechtomov

Saint-Petersburg State University; St. Petersburg Branch of N. I. Vavilov Institute of General Genetics

Email: ingevechtomov@gmail.com

Academician of the RAS, D.Sc., Prof., Head of the Dep. of Genetics and Breeding Saint Petersburg state university, Director of St. P etersburg Branch of N. I. Vavilov Institute of General Genetics

Russian Federation, 7/9, Universitetskaya nab., St.Petersburg, 199034; St.Petersburg

Alexey P. Galkin

Saint-Petersburg State University; St. Petersburg Branch of N. I. Vavilov Institute of General Genetics

Email: apgalkin@mail.ru

Ph.D., associate professor of St. Petersburg State University, deputy chief of St. Petersburg Branch of N. I. Vavilov Institute of General Genetics

Russian Federation, 7/9, Universitetskaya nab., St.Petersburg, 199034; St.Petersburg

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Copyright (c) 2012 Rubel A.A., Korzhova V.V., Saifitdinova A.F., Antonez K.S., Inge-Vechtomov S.G., Galkin A.P.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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