Genetic predisposition to helminthiasis

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Abstract

Helminthes accompany human beings from the early period of the formation, there is a long-term coevolution between parasite and human, helminthes represent a major selective force for human immune genes. Data on genetic control of the intensity and clinical traits of helminthinfection in different populations, including results obtained by whole-genome studies are presented and concept of common genes of susceptibility to helminth infection and allergic diseases are discussed.

About the authors

Irina Vladimirovna Saltykova

Siberian State Medical University

Email: ira.saltikova@mail.ru
PhD, junior research fellow, Central research laboratory

Maksim Borisovich Freydin

Institute of Medical Genetics of the Tomsk Scientific Center SD

Email: mfreidin@medgenetics.ru
PhD, senior research fellow, Laboratory of Population Genetics

Lyudmila Mikhaylovna Ogorodova

Siberian State Medical University

Email: lm-ogorodova@mail.ru
MD, Professor, Head of Department, corresponding member of RAMS, Department of faculty pediatric

Valeriy Pavlovich Puzyrev

Institute of Medical Genetics of the Tomsk Scientific Center SD

Email: valery.puzyrev@medgenetics.ru
MD, academician of RAMS, Professor, Director, Laboratory of Population Genetics

References

  1. Бычков В. Г., Сергиев В. П., Сабиров А. Х. и др., 2007. Молекулярно-генетические подходы в паразитологии (на примере описторхоза) // Мед. паразитол. Т. 2. С. 1–7.
  2. Ильинских Е. Н., 2002. Актуальные вопросы изучения проблемы описторхоза в Сибири // Бюллетень сибирской медицины. T. 1. C. 63–70.
  3. Лепехин А. В., Мефодиев В. В., Филатов В. Г., Бужак Н. С., 1992. Эпидемиология, клиника и профилактика описторхоза. Томск: Изд-во Том. ун-та. C. 232.
  4. Лукманова Г. И., Гумеров А. А., Билалов Ф. С. и др., 2008. Ассоциации генотипов гена CY1A1 с предрасположенностью к эхинококкозу, вызванному штаммом GL Echinicoccus granulosus // Мед. паразитол. Т. 3. С. 17–19.
  5. Лукманова Г. И., Комиссарова М. А., Гумеров А. А., Викторова Т. В, 2006. Полиморфизм генов глютатион-s-трансферазML и TL и риск заболевания детей эхинококкозом // Мед. паразитол. Т. 3. С. 15–18.
  6. Салтыкова И. В. Патогенетика иммунного ответа у больных бронхиальной астмой и описторхозом: автореф. дис.. на соиск. учен. степ. канд. мед. наук (03.02.07). СибГМУРосздрава. Томск, 2010. 20 с.
  7. Щербаков A. M., Монхе-Барредо П. А., 1989. Распределение антигенов системы HLA среди больных эхинококкозами // Мед. паразитол. Т. 6. С. 75.
  8. Abdel-Salam E., Abdel Khalik A., Abdel-Meguid A. et al., 1986. Association of HLA class I antigens (A1, B5, B8 and CW2) with disease manifestations and infection in human Schistosomiasis mansoni in Egypt // Tissue Antigens. Vol. 27. P. 142–146.
  9. Abel L., Demenais F., Prata A. et al., 1991. Evidence for the segregation of a major gene in human susceptibility / resistance to infection by Schistosoma mansoni // Am. J. Hum. Genet. Vol. 48. P. 959–970.
  10. Acevedo N., Mercado D., Vergara C. et al., 2009. Association between total immunoglobulin E and antibody responses to naturally acquired Ascarislum bricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes // Clin. Exp. Immunol. Vol. 157. P.282–90.
  11. Ali M. M., ElghazaliG., MontgomeryS. M. et al., 2007. Fc gamma RIIa (CD32) polymorphism and onchocercal skin disease: implications for the development of severe reactive onchodermatitis (ROD) // Am. J. Trop. Med. Hyg. Vol. 77. P. 1074–1078.
  12. Azab M. E., Bishara S. A., Helmy H. et al., 2004. Association of some HLA-DRB1 antigens with Echinococcus granulosus specific humoral immune response // J. Egypt Soc. Parasitol. Vol. 34. — P. 183–96.
  13. Bethony J., Gazzinelli A., Lopes A. et al., 2001. Genetic epidemiology of fecal egg excretion during Schistosoma mansoni infection in an endemic area in Minas Gerais, Brazil. // Mem Inst. Oswaldo. Cruz. Vol. 96. P. 49–55.
  14. Bethony J., Williams J. T., Blangero J. et al., 2002. Additive host genetic factors influence fecal egg excretion rates during Schistosoma mansoni infection in a rural area in Brazil//Am. J. Trop. Med. Hyg. Vol. 67. — P. 336–343.
  15. Bin Dajem S. M., Mostafa O. M., El-Said F. G., 2008. Susceptibility of two strains of mice to the infection with Schistosoma mansoni: parasitological and biochemical studies // Parasitol Res. Vol. 103. — P. 1059–1063.
  16. Buvanendran V., Sooriyamoorthy T., Ogunsusi R. A., Adu I. F., 1981. Haemoglobin polymorphism and resistance to helminths in Red Sokoto goats // Trop Anim. Health Prod. Vol. 13. P. 217–221.
  17. Chan L., Bundy D. A. P., Kan S. P., 1994. Aggregation and predisposition to Ascaris lumbricoides and Trichuri strichiura at the familial level // Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol. 88. P. 46–48.
  18. Chevillard C., Moukoko C. E., Elwali N. E. et al. IFN-gamma polymorphisms (IFN-gamma +2109 and IFN-gamma +3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni) //J. Immunol. Vol. 171. P. 5596–5601.
  19. Chiarella J. M., Goldberg A. C., Abel L. et al., 1998. Absence of linkage between MHC and a gene involved in susceptibility to human schistosomiasis // Braz. J. Med. Biol. Res. Vol. 31. P. 665–670.
  20. Choi E. H., Zimmerman P. A., Foster C. B. et al., 2001. Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bancrofti in South India // Genes. Immun. Vol. 2. — P. 248–53.
  21. Cooper P. J., Guevara A. E., Guderian R. H., 1993. Intestinal helminthiases in Ecuador: the relationship between prevalence, genetic, and socioeconomic factors // Rev. Soc. Bras. Med. Trop. Vol. 26. — P. 175–180.
  22. Cuenco K. T., Ottesen E. A., Williams S. A. et al., 2009. Heritable factors play a major role in determining host responses to Wuchereria bancrofti infection in an isolated South Pacific island population // J Infect Dis. Vol. 200. P. 1271–1278.
  23. Dawkins H. J., Windon R. G., Eagleson G. K., 1989. Eosinophil responses in sheep selected for high and low responsiveness to Trichostrongy luscolubriformis // J. Helminthol. Vol. 63. P. 302–306.
  24. Debrah A. Y., Batsa L., Albers A. et al., 2011. Transforming growth factor-β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis // Hum. Immunol. Vol. 72. — P. 1143–1148.
  25. Dessein A., Chevillard C., Arnaud V. et al., 2009. Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes // J. Exp. Med. Vol. 206. P. 2321–2328.
  26. Dessein A. J., Hillaire D., Elwali N. E. et al., 1999. Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-gamma receptor gene // Am. J. Hum. Genet. Vol. 65. P. 709–721.
  27. Dessein A. J., Hillaire D., Elwali N. E. et al., 1999. Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-gamma receptor gene // Am. J. Hum. Genet. Vol. 65. P. 709–721.
  28. Eiermann T. H., Bettens F., Tiberghien P. et al., 1998. HLA and alveolar echinococcosis // Tissue Antigens. Vol. 52. P. 124–129.
  29. Ellis M. K., Raso G., Li Y. S. et al., 2007. Familial aggregation of human susceptibility to coand multiple helminth infections in a population from the Poyang Lake region, China // Int. J. Parasitol. Vol. 37. P. 1153–1161.
  30. Fanning M. M., Kazura J. W., 1983. Genetic association of murine susceptibility to Brugiamalayi microfilaraemia // Parasite. Immunol. Vol. 5. P. 305–316.
  31. Forrester J. E., Scott M. E., Bundy D. A., Golden M. H., 1990. Predisposition of individuals and families in Mexico to heavy infection with Ascarislum bricoides and Trichuri strichiura // Trans. R. Soc. Trop. Med. Hyg. Vol. 84. P. 272–276.
  32. Fumagalli M., Pozzoli U., Cagliani R. et al., 2009. Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions // J. Exp. Med. Vol. 206, N 6. P. 1395–408.
  33. Garcia A., Abel L., Cot M. et al., 1999. Genetic epidemiology of host predisposition microfilaraemia in human loiasis // Trop. Med. Int. Health. Vol. 4. — P. 567–574.
  34. Gatlin M. R., Black C. L., Mwinzi P. N. et al., 2009. Association of the gene polymorphisms IFN-gamma +874, IL-13 –1055 and IL-4 –590 with patterns of reinfection with Schistosoma mansoni // PLoSNegl Trop Dis. Vol. 3. P. e375.
  35. Gibbens J. C., Harrison L. J., Parkhouse R. M., 1986. Immunoglobulin class responses to Taeniatae niaeformis in susceptible and resistant mice // Parasite Immunol. Vol. 8. P. 491–502.
  36. Hirayama K., Chen H., Kikuchi M. et al., 1999. HLA-DR-DQ alleles and HLA-DP alleles are independently associated with susceptibility to different stages of post-schistosomal hepatic fibrosis in the Chinese population // Tissue Antigens. Vol. 53. P. 269–274.
  37. Hise A. G., Hazlett F. E., Bockarie M. J. et al., 2003. Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis // Genes. Immun. Vol. 4. P. 524–527.
  38. Holland C. V., Crompton D. W., Asaolu S. O. et al., 1992. A possible genetic factor influencing protection from infection with Ascarislum bricoides in Nigerian children // J. Parasitol. Vol. 78. P. 915–916.
  39. Idris Z. M., Miswan N., Muhi J. et al., 2011. Association of CTLA4 gene polymorphisms with lymphatic filariasis in an East Malaysian population // Hum Immunol. Vol. 72. P. 607–612.
  40. Ishii A. I., Sano M., 2004. Strain-dependent differences in susceptibility of mice to experimental Angiostrongy luscostaricensis infection // Am. J. Trop. Med. Hyg. Vol. 70. P. 57–62.
  41. Isnard A., Kouriba B., Doumbo O., Chevillard C., 2011. Association of rs7719175, located in the IL13 gene promoter, with Schistosoma haematobium infection levels and identification of a susceptibility haplotype // Genes Immun. Vol. 12. P. 31–39.
  42. Junpee A., Tencomnao T., Sanprasert V., Nuchprayoon S. 2010. Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis // Parasitol Res. Vol. 107. — P. 807–816.
  43. Kariuki H. C., Mbugua G., Magak P. et al., 2001. Prevalence and familial aggregation of schistosomal liver morbidity in Kenya: evaluation by new ultrasound criteria // J Infect Dis. Vol. 183. P. 960–966.
  44. Kassim O. O., Ejezie G. C., 1982. ABO blood groups in malaria and schistosomiasis haematobium // Acta. Trop. Vol. 39. P. 179–184.
  45. Keller A. E., Leathers W. S., Knox J. C., 1937. The present status of hookworm infestation in North Carolina // Am. J. Hyg. Vol. 26. P. 437–454.
  46. King C. H., Blanton R. E., Muchiri E. M. et al., 1999. Low heritable component of risk for infection intensity and infection-associated disease in urinary schistosomiasis among Wadigo village populations in Coast Province, Kenya // Trop. Med. Int. Health. Vol. 4. P. 565–574.
  47. Kiper N., Gerçeker F., Utine E. et al., 2010. TAP1 and TAP2 gene polymorphisms in childhood cystic echinococcosis // Parasitol Int. Vol. 59. P. 283–285.
  48. Kouriba B., Chevillard C., Bream J. H. et al., 2005. Analysis of the 5q31-q33 locus shows an association between IL13–1055C/T IL-13–591A/G polymorphisms and Schistosoma haematobium infections // J. Immunol. Vol. 174. P. 6274–6281.
  49. Kroeze W. K., Tanner C. E., 1989. Echinococcusmultilocularis: Susceptibility and responses to infection in inbred mice // Int. J. Parasitol. Vol. 19. P. 199–205.
  50. Lammas D. A., Mitchell L. A., Wakelin D., 1990. Genetic influences upon eosinophilia and resistance in mice infected with Mesocestoi descorti // Parasitology. Vol. 101. P. 291–299.
  51. Marquet S., Abel L., Hillaire D. et al., 1996. Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33 // Nat. Genet. Vol. 14. P. 181–184.
  52. May J., Kremsner P. G., Milovanovic D., 1998. HLA-DP control of human Schistosoma haematobium infection // Am. J. Trop. Med. Hyg. Vol. 59. P. 302–306.
  53. McCallum H. I., 1990 Covariance in parasite burdens: the effect of predisposition to infection // Parasitology. Vol. 100. P. 153–159.
  54. Meyer C. G., Gallin M., Erttmann K. D. et al., 1994. HLA–D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection // Proc. Natl Acad. Sci. USA Vol. 91. P. 7515–7519.
  55. Meyrowitsch D. W., Simonsen P. E., Garred P. et al., 2010. Association between mannose-binding lectin polymorphisms and Wuchereria bancrofti infection in two communities in north-eastern Tanzania // Tropical Medicine and Hygiene. Vol. 82. P. 115–120.
  56. Moller M., Gravenor M. B., Roberts S. E. et al., 2007. Genetic haplotypes of Th-2 immune signalling link allergy to enhanced protection to parasitic worms // Hum. Mol. Genet.Vol. 16. P. 1828–1836.
  57. Müller-Myhsok B., Stelma F. F., Guissé-Sow F. et al., 1997. Further evidence suggesting the presence of a locus, on human chromosome 5q31-q33, influencing the intensity of infection with Schistosoma mansoni // Am. J. Hum. Genet. Vol. 61. P. 452–454.
  58. Ndamba J., Gomo E., Nyazema N. et al., 1997. Schistosomiasis infection in relation to the ABO blood groups among school children in Zimbabwe // Ottesen E. A., Mendell N. R., MacQueen J. M. et al., 1981. Familial predisposition to filarial infection — not linked to HLA-A or-B locus specificities // Acta Trop. Vol. 38. P. 205–216.
  59. Ouf E. A., Ojurongbe O., Akindele A. A. et al., 2012. Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis // J Infect Dis. Vol. 206. P. 562–570.
  60. Panda A. K., Sahoo P. K., Kerketta A. S. et al., 2011. Human lymphatic filariasis: genetic polymorphism of endothelin-1 and tumor necrosis factor receptor II correlates with development of chronic disease // J. Infect. Dis. Vol. 204. P.315–322.
  61. Parate P. N., Wang de Y., Chew F. T. et al., 2010. Linkage disequilibrium pattern in asthma candidate genes from 5q31-q33 in the Singapore Chinese population // Ann. Hum. Genet. Vol. 74. P. 137–45.
  62. Peisong G., Yamasaki A., Mao X. Q. et al., 2004. An asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation // Genes Immun. Vol. 5. P. 58–62.
  63. Pullan R.L, Bethony J.M, Geiger S. M. et al., 2010 Human helminth co-infection: no evidence of common genetic control of hookworm and Schistosoma mansoni infection intensity in a Brazilian community // Int. J. Parasitol. Vol. 1. P. 299–306.
  64. Ramsay C. E., Hayden C. M., Tiller K. J. et al., Association of polymorphisms in the beta2-adrenoreceptor gene with higher levels of parasitic infection // Rupert J., Quinnell., 2003. Genetics of susceptibility to human helminth infection // International Journal for Parasitology. Vol. 33. P. 1219–1231.
  65. StoreyN., Wakelin D., Behnke J. M., 1985. The genetic control of host responses to Dipetalonema viteae (Filarioidea) infections in mice // Parasite. immunology. Vol. 7. P. 349–58.
  66. Tangkawattana S., Kaewkes S., Pairojkul C. et al., 2008. Mutations of KRAS and TP53 in a minor proportion of Opisthorchis viverrini-associated cholangiocarcinomas in a hamster model // Asian. Pac. J. Cancer. Prev.Vol. 9. P. 101–106.
  67. Timmann C., van der Kamp E., Kleensang A. et al., 2008. Human genetic resistance to Onchocerca volvulus: evidence for linkage to chromosome 2p from an autosome-wide scan // J. Infect. Dis. Vol. 198. P. 427–33.
  68. Trangle K. L., Goluska M. J., O'Leary M. J., Douglas S. D., 1979. Distribution of blood groups and secretor status in schistosomiasis // Parasite Immunol. Vol. 1. P. 133–140.
  69. Williams J. T., Blangero J., 1999. Power of variance component linkage analysis to detect quantitative trait loci // Ann. Hum. Genet. Vol. 63. P. 545–563.
  70. Williams-Blangero S., VandeBerg J. L., Subedi J. et al., 2002. Genes on chromosomes 1 and 13 have significant effects on Ascaris infection // ProcNatlAcadSci U S A. Vol. 99. P. 5533–5538.
  71. Williams-Blangero S., Vandeberg J. L., Subedi J. et al., 2008. Two quantitative trait loci influence whipworm (Trichuri strichiura) infection in a Nepalese population // J. Infect. Dis. Vol. 197. P. 1198–1203.
  72. Yalcin E., Kiper N., Tan C. et al., 2010. The role of human leucocyte antigens in children with hydatid disease: their association with clinical condition and prognosis // Parasitol Res. Vol. 106. P. 795–800.
  73. Yazdanbakhsh M., Sartono E., Kruize Y. C. et al., 1995. HLA and elephantiasis in lymphatic filariasis // Hum. Immunol. Vol. 44. P. 58–61.
  74. Zhang S., Penfornis A., Harraga S. et al., 2003.Polymorphisms of the TAP1 and TAP2 genes in human alveolar echinococcosis // Eur. J. Immunogenet. Vol. 30. P. 133–139.
  75. Zinn-Justin A., Marquet S., Hillaire D. et al., 2001. Genome search for additional human loci controlling infection levels by Schistosoma mansoni // Am. J. Trop. Med. Hyg. Vol. 65. P. 754–758.

Copyright (c) 2013 Saltykova I.V., Freydin M.B., Ogorodova L.M., Puzyrev V.P.

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