Research of the influence of LIG4 gene polimorphism on chromosomal aberrations level in human lymphocytes, with background and excessive exposure to radon

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Abstract

Effects of the LIG4 gene polymorphisms rs1805388 (Thr9Ile) and rs1805389 (Ala3Val) on the level of chromosomal aberrations in peripheral blood lymphocytes have been estimated in children, that live and study in conditions of normal and excessive exposure to radon in several localitions of the Kemerovo region. There was no statistically significant difference between genotypic groups on the marker rs1805388 with regard to frequencies of cytogenetic indexes. At the same time, in the group of Val carriers (marker rs1805389) from second cohort our analysis revealed significant increase in the amount of paired fragments in comparison with homozygotes Ala/Ala.

About the authors

Aleksey Nikolayevich Volkov

Kemerovo State University

Email: volkov_alex@rambler.ru
docent, candidate of biological sciences

Tatyana Aleksandrovna Golovina

Kemerovo State University

Email: druzhinin_vladim@mail.ru
chief engineer, Chair of Genetics

Vladimir Gennadyevich Druzhinin

Kemerovo State University

Email: druzhinin_vladim@mail.ru
professor, doctor of biological sciences

Aleksey Viktorovich Larionov

Kemerovo State University

Email: larionov@mail.ru
engineer, candidate of biological sciences

Varvara Ivanovna Minina

Institute of Human Ecology SB RAS

Email: vminina@mail.ru
senior research fellow, candidate of biological sciences

Anna Aleksandrovna Timofeyeva

Institute of Human Ecology SB RAS

Email: vminina@mail.ru
engineer, Laboratory of Сytogenetics

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Copyright (c) 2013 Volkov A.N., Golovina T.A., Druzhinin V.G., Larionov A.V., Minina V.I., Timofeyeva A.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 


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