Research of the influence of                   LIG4 gene polimorphism on chromosomal aberrations level in human lymphocytes, with background and excessive exposure to radon

Aleksey Nikolayevich Volkov; Волков Алексей Николаевич; Tatyana Aleksandrovna Golovina; Головина Татьяна Александровна; Vladimir Gennadyevich Druzhinin; Дружинин Владимир Геннадьевич; Aleksey Viktorovich Larionov; Ларионов Алексей Викторович; Varvara Ivanovna Minina; Минина Варвара Ивановна; Anna Aleksandrovna Timofeyeva; Тимофеева Анна Александровна

doi:10.17816/ecogen11216-21

Research of the influence of LIG4 gene polimorphism on chromosomal aberrations level in human lymphocytes, with background and excessive exposure to radon

Authors: Volkov A.N.¹, Golovina T.A.¹, Druzhinin V.G.¹, Larionov A.V.¹, Minina V.I.², Timofeyeva A.A.²
Affiliations:
1. Kemerovo State University
2. Institute of Human Ecology SB RAS
Issue: Vol 11, No 2 (2013)
Pages: 16-21
Section: Articles
URL: https://journals.rcsi.science/ecolgenet/article/view/2454
DOI: https://doi.org/10.17816/ecogen11216-21
ID: 2454

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Abstract

Effects of the LIG4 gene polymorphisms rs1805388 (Thr9Ile) and rs1805389 (Ala3Val) on the level of chromosomal aberrations in peripheral blood lymphocytes have been estimated in children, that live and study in conditions of normal and excessive exposure to radon in several localitions of the Kemerovo region. There was no statistically significant difference between genotypic groups on the marker rs1805388 with regard to frequencies of cytogenetic indexes. At the same time, in the group of Val carriers (marker rs1805389) from second cohort our analysis revealed significant increase in the amount of paired fragments in comparison with homozygotes Ala/Ala.

Keywords

LIG4, radon, chromosomal aberrations, genetic polymorphism, DNA repair genes, LIG4

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Research of the influence of LIG4 gene polimorphism on chromosomal aberrations level in human lymphocytes, with background and excessive exposure to radon

Full Text

Abstract

Keywords

Full Text

About the authors

Aleksey Nikolayevich Volkov

Tatyana Aleksandrovna Golovina

Vladimir Gennadyevich Druzhinin

Aleksey Viktorovich Larionov

Varvara Ivanovna Minina

Anna Aleksandrovna Timofeyeva

References

Supplementary files