Effects of the intestinal microbiota on epigenetic mechanisms involved in the development of post-stress neuro-inflammation

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Abstract

A number of alleles of polymorphic genes, dysfunctions of the hypothalamic-pituitary-adrenal axis, neurotransmitter disorders, and manifestations of immune dysregulation are associated with vulnerability to stress. Post-stress states of humans and animals are accompanied by signs of neuroinflammation, the causes and mechanisms of which remain to be elucidated. The article discusses epigenetic mechanisms by which the intestinal microbiota might participate in the initiation and maintenance of post-stress inflammation.

About the authors

Irina G. Shalaginova

Immanuel Kant Baltic Federal University

Author for correspondence.
Email: shalaginova_i@mail.ru
ORCID iD: 0000-0002-0140-3077
SPIN-code: 1160-1915
Scopus Author ID: 57202052229
ResearcherId: J-3626-2018

Senior Lecturer, School of Life Science

Russian Federation, ul. Nevskogo, 14, Kaliningrad, 236041

Liudmila V. Matskova

Immanuel Kant Baltic Federal University
 

Email: liudmila.matskova@ki.se
ORCID iD: 0000-0002-3174-1560
SPIN-code: 4756-7437
Scopus Author ID: 6507748788
ResearcherId: F-3003-2016

PhD, professor-researcher, Microbiology and Biotechnology Unit of School of Life Science

Russian Federation, ul. Nevskogo, 14, Kaliningrad, 236041

Natalia M. Gunitseva

Immanuel Kant Baltic Federal University
 

Email: nat-gun@mail.ru

student in Bioengineering and bioinformatics, School of Life Science

Russian Federation, ul. Nevskogo, 14, Kaliningrad, 236041

Irina A. Vakoliuk

Immanuel Kant Baltic Federal University
 

Email: vakoluk@mail.ru
ORCID iD: 0000-0001-5480-1645
SPIN-code: 2378-7129
Scopus Author ID: 7801465798

PhD, associate professor, School of Life Science

Russian Federation, ul. Nevskogo, 14, Kaliningrad, 236041

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