The immune response to the novel coronavirus infection
- Authors: Fedorov V.S.1, Ivanova O.N.1, Karpenko I.L.1, Ivanov A.V.1
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Affiliations:
- Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
- Issue: Vol 12, No 1 (2021)
- Pages: 33-40
- Section: Reviews
- URL: https://journals.rcsi.science/clinpractice/article/view/64677
- DOI: https://doi.org/10.17816/clinpract64677
- ID: 64677
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Abstract
This review summarizes the current knowledge on the humoral and T-cell immunity to the novel coronavirus infection. A special attention is paid to the viral proteins that induce production of antibodies, different types of immunoglobulins and their role in the protection against the virus as well as to the duration of the humoral immune response. In addition, a concise analysis of the T-cell immunity status during COVID-19 and its input into the antiviral defense is presented. The collected data demonstrating preservation of both the humoral and T-cell immunity are urgently needed in the medical professionals' community for evidence-based decisions on the immunity monitoring, estimation of (re)vaccination time, as well as for knowing the factors that should be considered while choosing the most effective vaccine. Finally, several directions for the future research are pointed out
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##article.viewOnOriginalSite##About the authors
Vyacheslav S. Fedorov
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: fedorovvyach@gmail.com
Laboratory Research Assistant
Russian Federation, 32, Vavilov street, Moscow, 119991Olga N. Ivanova
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: olgaum@yandex.ru
ORCID iD: 0000-0002-3673-4714
Cand. Sci. (Biol.), Research Associate
Russian Federation, 32, Vavilov street, Moscow, 119991Inna L. Karpenko
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: ilkzkil@gmail.com
ORCID iD: 0000-0001-9849-0447
SPIN-code: 1699-6450
Cand. Sci. (Chemical), Senior Research Associate
Russian Federation, 32, Vavilov street, Moscow, 119991Alexander V. Ivanov
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Author for correspondence.
Email: aivanov@yandex.ru
ORCID iD: 0000-0002-5659-9679
SPIN-code: 5776-5496
Head of the lab
Russian Federation, 32, Vavilov street, Moscow, 119991References
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