Solitary cutaneous neoplasms: analysing the uncertain behaviour with the aid of histopathology
- Authors: Sreedevi L.1, Rao D.E.2, Kumari A.V.1, Niharika M.1, Sravani P.1, Naik V.S.1
-
Affiliations:
- Government Medical College
- Andhra Medical College
- Issue: Vol 15, No 2 (2024)
- Pages: 39-50
- Section: Original Study Articles
- URL: https://journals.rcsi.science/clinpractice/article/view/262724
- DOI: https://doi.org/10.17816/clinpract625962
- ID: 262724
Cite item
Abstract
BACKGROUND: Skin tumours can be classified as either benign or malignant, resulting due to the proliferation of one or more components of the skin. Reportedly, there has been a rise in the prevalence of skin cancer in recent decades, which has led to rely on histological evidence to distinguish between various types of skin cancer.
AIM: This study aims to provide a comprehensive description of the occurrence, symptoms, unpredictable nature, and range of histopathological spectrum in different types of skin tumours.
METHODS: This prospective research was conducted in the outpatient department of the Department of Dermatology at the Government General Hospital in Anantapur from July 2019 to July 2023. Patients who did not provide informed consent, those with infectious or cystic swellings, or those with multiple lesions were excluded from this study. Histopathological confirmation is obtained from all excisional biopsies of single cutaneous swellings, and tumours are classified based on the criteria established by the World Health Organization (WHO).
RESULTS: The study included a total of 123 individual cutaneous tumours, with 98 cases (79.67%) being classified as benign and 25 cases (20.32%) classified as malignant. The age group most affected is adults between the ages of 26 and 44, with a prevalence rate of 31.7%. Following closely behind are middle-aged individuals, with a prevalence rate of 30.08%. The males constitute 46.34% (57 cases) and the females constitutes 53.65% (66 cases). The extremities were the most frequently affected site, accounting for 53 cases (43.08%), followed by the head and neck region (29.26%). Based on the WHO classification of skin tumours, there were 42 cases (34.14%) of subcutaneous tissue tumours and 31 cases (25.20%) of soft tissue tumours. The prevalence of keratinocyte tumours is 26 (21.13%), whereas appendageal tumours account for 16 (13%) of cases. Melanocytic and neural tumours are the least prevalent, each representing 4 (3.25%) of cases. The majority of benign tumours arise from the subcutaneous tissues, whereas malignant tumours grow from keratinocytic differentiation.
CONCLUSION: Our study revealed that the majority of tumours displayed ambiguous clinical behaviour, which resulted in erroneous diagnoses. Hence confirmation by histopathology is crucial for accurate diagnosis and prompt management.
Full Text
##article.viewOnOriginalSite##About the authors
Lekkala Sreedevi
Government Medical College
Author for correspondence.
Email: drsreelekkala@gmail.com
ORCID iD: 0009-0006-3239-320X
Associate Professor of DVL
India, Anantapur, Andhra PradeshD. Edukondala Rao
Andhra Medical College
Email: dhanyasiekora39@gmail.com
ORCID iD: 0009-0002-2440-8994
Associate Professor of DVL
India, Visakhapatnam, Andhra PradeshA. Vijaya Kumari
Government Medical College
Email: drvijayakabburam@gmail.com
Associate Professor of DVL
India, Anantapur, Andhra PradeshMachani Niharika
Government Medical College
Email: harikamachani@gmail.com
ORCID iD: 0009-0009-7709-8302
Junior Resident of DVL
India, Anantapur, Andhra PradeshP. Sravani
Government Medical College
Email: chenna2593@gmail.com
ORCID iD: 0000-0001-8859-6758
Associate Professor of Pathology
India, Anantapur, Andhra PradeshV. Sivasankara Naik
Government Medical College
Email: vssnaik73@gmail.com
ORCID iD: 0009-0001-5792-5456
Professor & HOD of Pathology
India, Anantapur, Andhra PradeshReferences
- Breathnach SM. Drug reactions. In: Champion RH, Burton JL, Burns T, Breathnach S, editor. Rook/Wilkinson/ebling: Textbook of dermatology (Four-Volume Set). 6th edn. London: Blackwell Science; 1998. P. 3349–3517.
- Carrow A, Brownstein BR. Tumors of skin. In: Moschella SL, Hurley HJ, editor. Dermatology. 2nd edn. WB Saunders Company, Philadelphia; 1996. 1721 р.
- Khandpur S, Ramam M. Skin tumours. J Cutan Aesthet Surg. 2012;5(3):159–162. doi: 10.4103/0974-2077.101368
- Elder DE, Massi D, Scolyer RA, Willemze R, editor. WHO Classification of Skin Tumours. Vol. 11. 4th edition. WHO Classification of Tumours; 2018.
- Dyussenbayev A. Age periods of human life. Adv Social Sci Res J. 2017;4(6):258–263. doi: 10.14738/assrj.46.2924
- Schneider SL, Kholi I, Hamzavi IH, et al. Emerging imaging technologies in dermatology: Part II: Basic prinicples. J Am Acad Dermatol. 2019;80(4):1121–1131. doi: 10.1016/j.jaad.2018.11.043
- Schneider SL, Kholi I, Hamzavi IH, et al. Emerging imaging technologies in dermatology. Part I: Applications and limitations. J Am Acad Dermatol. 2019;80(4):1114–1120. doi: 10.1016/j.jaad.2018.11.042
- Compton LA, Murphy GF, Lian CG. Diagnostic Immunohistochemistry in Cutaneous Neoplasia: An update. Dermatopathology (Basel). 2015;2(1):15–42. doi: 10.1159/000377698
- Morosin T, Ashford B, Ranson M, et al. Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: A pilot study. Oncotarget. 2016;7:47111–47115. doi: 10.18632/oncotarget.9946
- Lianidou E, Hoon D. Circulating tumor cells and circulating tumor DNA. In: Nader R, Horrath A, Wittwer C, editors. Tietz textbook of clinical chemistry and molecular diagnostics. 6th ed. Elsevier Ltd., Amsterdam, Netherlands; 2017. P. 1111–1144.
- Soglia S, Pérez-Anker J, Lobos Guede N, et al. Diagnostics using non-invasive technologies in dermatological oncology. Cancers (Basel). 2022;14(23):5886. EDN: CWEZMR doi: 10.3390/cancers14235886
- Murphy R. Introduction to AI robotics, second edition. MIT Press, Cambridge, MA, USA; 2019. 648 р.
- Mitra B, Craswell N. An introduction to neural information retrieval. Now Publishers Inc., Boston, MA, USA; 2018. P. 1–126. doi: 10.1561/1500000061
- Patel N, Suthar T, Suthar H, Arora A. A study of tumours, tumour like lesions and cysts of epidermis and its appendages. Ind J Clin Exp Dermatol. 2018;4(3):194–200. doi: 10.18231/2581-4729.2018.0042
- Goel P, Kaur S, Garg A, et al. A clinicopathological study of skin tumors from a tertiary care centre in North India. Indian Dermatol Online J. 2021;12(1):66–71. doi: 10.4103/idoj.IDOJ_257_20
- Shrivastava V, Tangde A, Joshi A, Bindu R. Clinicopathological study of skin tumours. Int J Res Med Sci. 2019;7(5):1712–1719. doi: 10.18203/2320-6012.ijrms20191664
- Alsaad KO, Obaidat NA, Ghazarian D. Skin adnexal neoplasms. Part 1: An approach to tumours of the pilosebaceous unit. J Clin Patholog. 2007;60(2):129–144. doi: 10.1136/jcp.2006.040337
- Mahajan S, Mahaja A, Chopra M. A Retrospective study of morphology and histology of cutaneous appendageal tumours from Northern India. Res J Med Sci. 2024;18:114–119. doi: 10.59218/makrjms.2024.6.114.119
- Sharma N, Nakra T, Agarwal S, et al. Cutaneous adnexal tumours: A study of 395 cases from a tertiary care hospital. Indian J Dermatol. 2023;68(1):41–44. doi: 10.4103/ijd.ijd_586_22
- Sharma A, Paricharak DG, Nigam JS, et al. Histopathological study of skin adnexal tumours-institutional study in South India. J Skin Cancer. 2014;2014:543756. doi: 10.1155/2014/543756
- Pappala P, Raksha S, Vasundara G, et al. Histopathological study of skin tumours. Indian J Pathol Oncol. 2019;6(4):543–547. doi: 10.18231/j.ijpo.2019.106
- Pujani M, Madaan GB, Jairajpuri ZS, et al. Adnexal tumors of skin: An experience at a tertiary care center at Delhi. Ann Med Health Sci Res. 2016;6(5):280–285. doi: 10.4103/amhsr.amhsr_339_14
- Rajalakshmi V, Selvakumar S, Rajeswari K, et al. Case series of skin adnexal tumours. J Clin Diagn Res. 2014;8(9):FC07-10. doi: 10.7860/JCDR/2014/8710.4844
- Nair PS. A clinicopathologic study of skin appendageal tumors. Indian J Dermatol Venereol Leprol. 2008;74(5):550. doi: 10.4103/0378-6323.44339