Dynamics of indicators of the vascular membrane of the ciliary body in predicting the risk of diabetic retinopathy in pregnant women with diabetes mellitus
- Authors: Khomiakova E.N.1, Afanaseva A.A.1, Loskutov I.A.1
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Affiliations:
- Moscow Regional Research and Clinical Institute
- Issue: Vol 15, No 2 (2024)
- Pages: 7-19
- Section: Original Study Articles
- URL: https://journals.rcsi.science/clinpractice/article/view/262720
- DOI: https://doi.org/10.17816/clinpract626630
- ID: 262720
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Abstract
BACKGROUND: According to statistics, microvascular complications of diabetes mellitus are registered in a third of patients during their lifetime, and diabetic retinopathy is the main cause of irreversible blindness in people of reproductive age. Changes in the vascular membrane of the eye in patients with diabetes mellitus are currently being studied as predictors of the progression of diabetic retinopathy. Further study of changes in the vascular membrane in pregnant women with type 1 and type 2 diabetes may help in identifying criteria for the manifestation and progression of diabetic microangiopathy.
AIM: To develop a methodology for predicting the risk of diabetic retinopathy progression by analyzing the dynamics of the state of the vascular membrane of the ciliary body.
METHODS: The study was conducted in each trimester of pregnancy. A pregnant patient with confirmed diabetes mellitus 1 or diabetes mellitus 2 underwent a comprehensive ophthalmological examination, including visometry with maximally corrected visual acuity, tonometry, biomicroscopy of the anterior segment of the eye, ophthalmoscopy under conditions of drug-induced mydriasis (phenylephrine) with a high-diopter lens (78–90 D), and optical coherence tomography of the anterior and posterior eye segments.
RESULTS: With an increase in the thickness of the vascular layer of the ciliary body by ≥10% at one or more points compared with the study conducted in the first trimester of pregnancy, the patients exhibited diabetic retinopathy progression during subsequent routine examinations. Quantitative analysis of the vascular layer of ciliary body revealed the transition of diabetic retinopathy to its next stage; however, photoregistration of the fundus did not show obvious signs of transformation into another stage of the disease.
CONCLUSION: Dynamic examination of the thickness of the vascular layer of the ciliary body during gestation and its increase by 10% from the initial one enables prediction of progression of diabetic retinopathy to the next stage.
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##article.viewOnOriginalSite##About the authors
Elena N. Khomiakova
Moscow Regional Research and Clinical Institute
Email: veritas.elena@gmail.com
ORCID iD: 0000-0002-4460-3968
SPIN-code: 2200-0320
MD, PhD, Associate Professor
Russian Federation, MoscowAnna A. Afanaseva
Moscow Regional Research and Clinical Institute
Author for correspondence.
Email: anna_amor@mail.ru
ORCID iD: 0000-0002-6307-5582
SPIN-code: 3539-6607
Russian Federation, Moscow
Igor A. Loskutov
Moscow Regional Research and Clinical Institute
Email: loskoutigor@mail.ru
ORCID iD: 0000-0003-0057-3338
SPIN-code: 5845-6058
MD, PhD
Russian Federation, MoscowReferences
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