Clinical case: severe course of adenoviral conjunctivitis with a hemorrhagic component complicated by a toxic-allergic reaction against a pregnancy
- Authors: Trubilin V.N.1, Poluninа E.G.1, Andzhelova D.V.2, Kasparova E.A.2, Evstigneeva Y.V.3
-
Affiliations:
- Federal institute of the professional development
- Research Institute of Eye Diseases
- Ophthalmology Clinic of Dr. Kurenkov
- Issue: Vol 9, No 1 (2018)
- Pages: 76-81
- Section: Case reports
- URL: https://journals.rcsi.science/clinpractice/article/view/10777
- DOI: https://doi.org/10.17816/clinpract09176-81
- ID: 10777
Cite item
Full Text
Abstract
One of the manifestations of adenovirus keratoconjunctivitis – extensive subconjunctival hemorrhages – is the characteristic of rather rare hemorrhagic form of conjunctivitis of severe course. Patients, especially pregnant women, with clinical manifestations of adenoviral conjunctivitis of severe course with a hemorrhagic component complicated by a toxic-allergic reaction, require close attention not only from ophthalmologists. It is necessary to conduct a comprehensive examination, including: general blood test, coagulogram, consultation of the therapist. Clinical signs of deterioration, in the early days of the disease, against the backdrop of treatment, is a clinical feature of the course of adenovirus infection, which should be informed to the patient. The use of a complex approach using the domestic non-toxic inducer of interferon formation of Poludan (polyA:polyU complex) in instillations and injections, supplemented by scraping-massage with a glass rod of the tarsal conjunctiva, facilitating the elimination of adenovirus from conjunctival follicles, quickly and effectively reversed the phenomenon of severe AVC. The appointment of corticosteroid therapy, regardless of the severity of the toxic-allergic reaction, is shown no earlier than 7 days after the manifestation of the disease.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
V. N. Trubilin
Federal institute of the professional development
Author for correspondence.
Email: trubilinmd@mail.ru
д.м.н., профессор, Заведующий кафедрой офтальмологии ФГБОУ «Институт повышения квалификации Федерального медикобиологического агентства»
Russian Federation, 15, Gamalei str., Moscow, 123098E. G. Poluninа
Federal institute of the professional development
Email: lpolunina@mai.ru
ORCID iD: 0000-0002-8551-0661
д.м.н., профессор кафедры офтальмологии
Russian Federation, 15, Gamalei str., Moscow, 123098D. V. Andzhelova
Research Institute of Eye Diseases
Email: andgelova@mail.ru
д.м.н., старший научный сотрудник
Russian Federation, 11A,B, Rossolimo str., Moscow, 119021E. A. Kasparova
Research Institute of Eye Diseases
Email: kasparova_jane@mail.ru
к.м.н.,ведущий научный сотрудник
Russian Federation, 11A,B, Rossolimo str., Moscow, 119021Yu. V. Evstigneeva
Ophthalmology Clinic of Dr. Kurenkov
Email: j_dorado@mail.ru
врач офтальмолог офтальмологической клиники доктора Куренкова
Russian Federation, 48/1, Rublevskoe highway, Moscow, 121609References
- Majeed A, Naeem Z, Khan DA, Ayaz A. Epidemic adenoviral conjunctivitis report of an outbreak in a military garrison and recommendations for its management and prevention. J Pak Med Assoc. 2005;55:273–5.
- Azari AA, Barney NP. Conjunctivitis: a systematic review of diagnosis and treatment. JAMA. 2013;310:1721–9. doi: 10.1001/jama.2013.280318.
- Sambursky R., Tauber S., Schirra F. The RPS Adeno Detector for diagnosing adenoviral conjunctivitis. Ophthalmology. 2006;113:1758–1764.
- Orly Efros, Alon Zahavi, Hagai Levine, Michael Hartal. Clinical and public health management of conjunctivitis in the Israel Defense Forces Disaster Mil Med. 2015; 1: 12. doi: 10.1186/s40696-015-0002-3
- Andria M. Pihos Published online 2012 Sep 1. J Optom. 2013 Apr; 6(2): 69–74. doi: 10.1016/j. optom.2012.08.003
- Jin X., Ishiko H., Ha N.T. Molecular epidemiology of adenoviral conjunctivitis in Hanoi, Vietnam. Am J Ophthalmol. 2006;142:1064–1066. [PubMed]
- Butt A.L., Chodosh J. Adenoviral keratoc- onjunctivitis in a tertiary care eye clinic. Cornea.2006;25:199–202.
- Lenaerts L., De Clercq E., Naesens L. Clinical features and treatment of adenovirus infections. Rev Med Virol. 2008;18:357–374.
- Adhikary AK, Banik U. Human adenovirus type 8: the major agent of epidemic keratoconjunctivitis (EKC). J Clin Virol. 2014 Dec;61(4):477-86. doi: 10.1016/j. jcv.2014.10.015.
- Hashimoto S, Gonzalez G, Harada S, Oosako H, Hanaoka N, Hinokuma R, Fujimoto T. Recombinant type Human mastadenovirus D85 associated with epidemic keratoconjunctivitis since 2015 in Japan. J Med Virol. 2018 Feb 3. doi: 10.1002/jmv.25041.
- González-López JJ, Morcillo-Laiz R, Mu oz- Negrete FJ. Adenoviral keratoconjunctivitis: an update. Arch Soc Esp Oftalmol. 2013;88:108–15. doi: 10.1016/j. oftal.2012.07.007.
- Маркова Е.Ю., Полунина Е.Г., Иойлева Е.Э. Аллергические заболевания глаз у детей. Современный взгляд на патогенез и лечение. Офтальмология. 2017;14(2):125-129. doi: 10.18008/1816-5095-2017-2- 125-129
- Маркова Е.Ю., Пронько Н.А., Венедиктова Л.В. Детские инфекции. 2016. Т. 15. № 3. С. 57-61.
- Heymann DL. Control of Communicable Diseases Manual. Washington: American Public Health Association; 2004. pp. 124–30.
- Centers for Disease Control and Prevention (CDC) Adenovirus-associated epidemic keratocon- junctivitis outbreaks--four states, 2008–2010. MMWR. Morb. Mortal. Wkly. 2013;62:637–641.
- Cheung D., Bremner J., Chan J.T.K. Epidemic keratoconjunctivitis – do outbreaks have to be epidemic? Eye. 2003;17:356–363.
- GhebremedhinB.Humanadenovirus:Viralpathogen with increasing importance. Eur J Microbiol Immunol (Bp) 2014;4:26–33. doi: 10.1556/EuJMI.4.2014.1.2.
- Краснов М.М., Каспарова Е.А., Каспаров А.А. Клинические особенности и иммунотерапия осложненных форм аденовирусного кератоконъюнктивита. Вестник офтальмологии 1998.-N 5.-С.23-28.
- Shenoy KM. Adenoviral Keratoconjunctivitis In Malabar region. Physicians Academy. 2012 :4, 57-62
- Каспаров А.А. Офтальмогерпес. Медицина, Москва, 1994г. 223c.
- Каспарова Е.А., Каспарова Е.А., Каспаров А.А. Современная клиника и лечение аденовирусного кератоконъюнктивита. Эффективная фармакотерапия. 2015. № 30. С. 12-19.
- Краснов М.М., Каспаров А.А., Воробьева О.К., Ульянова Т.Ю., Каспарова Е.А., Фадеева Л.Л., и соавт. Полудан в лечении вирусных заболеваний глаз. Вестник офтальмологии. 1997. Т. 113. № 5. С. 35-39.
- Каспарова Е.А., Фадеева Л.Л., Павлюк А.С., Переверзина О.К., Каспаров А.А. К вопросу о теоретическом обосновании методики экспрессаутоцитокинотерапии. Вестник офтальмологии. 2002. Т. 118. № 3. С. 25-27.
- Pihos A.M. Epidemic keratoconjunctivitis: A review of current concepts in managementJournal of Optometry. 2013: 6:2; 69-74
- Romanowski E.G., Yates K.A., Gordon Y.J. Topical corticosteroids of limited potency promote adenovirus replication in the Ad5/NZW rabbit ocular model. Cornea. 2002;21:289–291
- . McManus MA, Khalessi AA, Lin J, Ashraf J, Reich SM.Positive feelings during pregnancy, early feeding practices, and infant health. Pediatr Int. 2017 May;59(5):593-599. doi: 10.1111/ped.13209.
- Undlien M, Viervoll HA, Rostad B. Effect of mother support groups on nutritional status in children under two years of age in Laisamis village, Kenya.Afr Health Sci. 2016 Dec;16(4):904-909. doi: 10.4314/ahs. v16i4.4.