EFFECT OF ANTICANCER DRUGS ON PRIMARY CELL CULTURES OF PATIENTS WITH COLORECTAL CANCER

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Abstract

The goal of the research is to estimate the effect of 5-Fluorouracil, Cisplatin, Tomudex, Leucovorin and their combinations on colorectal cancer cells in vitro. Cell response to the effect of cytotoxic compounds and immunomodulator was estimated by the change in chromosomal aberrations, cell growth rate, proliferative activity and colonyforming unit. It was detected that antineoplastic drugs affected the mutagenesis and fission rate of cultured cells.

About the authors

N V Golyasnaya

Институт экологии и генетики микроорганизмов УрО РАН

Email: golasnaya@mail.ru
ст.н.с. лаборатории химического мутагенеза Института экологии и генетики микроорганизмов УрО РАН,к.б.н.

Yu V Ivanov

ФГБУ ФНКЦ ФМБА России

заведующий отделением хирургии ФГБУ ФНКЦ ФМБА России, д.м.н.,профессор.

N S Zhizhin

ФГБУ ФНКЦ ФМБА России

Email: gigin2000@mail.ru
врач-колопроктолог, руководитель клиники лазерной проктологии ФГБУ ФНКЦ ФМБА России,к.м.н.

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Copyright (c) 2016 Golyasnaya N.V., Ivanov Y.V., Zhizhin N.S.

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