NEUTROPHIL-LYMPHOCYTE RATIO AS A PREDICTOR OF ADVERSE IN PATIENTS WITH HEART FAILUREOF NONCORONAROGENIC ETIOLOGY

Cover Page

Cite item

Full Text

Abstract

Aim of the study. To determine the prognostic significance of NLR ratio in patients with noncoronarogenic etiology HF during the hospital period and after hospital stay.Materials and methods. Totally, 75 patients were studied. LVEF<40%. The primary endpoint was a lethal outcome. Patients were divided into groups: 1) “dilated cardiomyopathy” (DCM) (n = 51); 2) “myocarditis” (n = 7); 3) “postmyocarditis cardiosclerosis” (n = 10); 4) “other” (n = 7). A general blood test was performed on the day of hospitalization and 7 days later. The long-term prognosis was analyzed according to the data of telephone contacts with patients, their relatives, outpatient cards.Results. A statistically significant relationship was established between NLR on the day of hospitalization and the overall mortality in the group “myocarditis” (NLR (%) = 2.23 + 0.78, p <0.05). NLR of the deceased in the group “DCM” was 3.98 + 0.60, which is significantly higher in comparison with the surviving patients in the same group (NLR 2.28 + 0.17, p<0.001). NLR was significantly decreased in all groups after 7 days (p<0.05 for the “DCM”, and NLR was practically comparable with the data of healthy people in the “PMCC”).Conclusions. The dynamic growth NLR of blood can serve as a predictor of death in patients suffering from DCM with LV EF<40%. NLR should be adopted for stratification of risk in this group of patients.

About the authors

M R Bakhchoyan

ФГБОУ ВО КубГМУ Минздрава России

Email: marbach1988@mail.ru
аспирант кафедры терапии №1 ФПК и ППС ФГБОУ ВО КубГМУ Минздрава России, врач-кардиолог ГБУЗ «НИИ - ККБ№1 им. проф. С.В. Очаповского»

E D Kosmacheva

ФГБОУ ВО КубГМУ Минздрава России

проф., д.м.н., заведующая кафедрой терапии №1 ФПК и ППС ФГБОУ ВО КубГМУ Минздрава России, Зам. главного врача по медицинской части ГБУЗ «НИИ - ККБ№1 им. проф. С.В. Очаповского»

A A Slavinsky

ФГБОУ ВО КубГМУ Минздрава России

проф. д.б.н., заведующий кафедрой патологической анатомии. ФГБОУ ВО КубГМУ Минздрава России.

References

  1. Моисеев В.С., Киякбаев Г.К. Кардиомиопатии и миокардиты. М.: «ГЭОТАР-Медиа», 2012, 345 с.
  2. Caforio AL, Pankuweit S, Arbustini E, et al. European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J. 2013 Sep;34(33):2636-48.
  3. Gupta S., Markham D.W., Drazner M.H., Mammen P. Fulminant myocarditis. Nature clinical practice cardiovascular medicine. 2008; 5 (11): 693-706
  4. Hare J. The dilated restrictive cardiomyopathies. - Braunwald: Braunwald’s Heart Disease, 2008. P. 1739-1762.
  5. Levy WC., Mozaffarian D., Linker D. The Seattle heart failure model: prediction of survival in heart failure. Circulation. 2006;113:1424.
  6. Фомин И.В. Выживаемость больных ХСН в когортной выборке Нижегородской области (данные 1998- 2002 годов.). Всероссийская конференция ОССН: «Сердечная недостаточность, 2005 год». М., 2005. с. 31-32.
  7. Vakili H, Shirazi M, Charkhkar M, et al.Correlation of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with thrombolysis in myocardial infarction frame count in ST-segment elevation myocardial infarction. Eur J Clin Invest. 2017 Apr; 47(4):322-327. doi: 10.1111/eci.12736.
  8. Yu C, Chen M, Chen Z2, et al. Predictive and prognostic value of admission neutrophil-tolymphocyte ratio in patients with CHD. Herz. 2016 Nov; 41(7): 605-613.
  9. Wasilewski J, Pyka Ł, Hawranek M et al. Prognostic value of neutrophil- to-lymphocyte ratio in predicting long-term mortality in patients with ischemic and nonischemic heart failure. Pol Arch Med Wewn. 2016;126(3):166-73. doi: 10.20452/pamw.3316.
  10. Benites-Zapata VA, Hernandez AV, Nagarajan V., et al. Usefulness of neutrophil-to-lymphocyte ratio in risk stratification of patients with advanced heart failure. Am J Cardiol. 2015 Jan 1;115(1):57-61. doi: 10.1016/j. amjcard.2014.10.008.
  11. Uthamalingam S, Patvardhan EA, Subramanian S. et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol. 2011 Feb 1;107(3):433-8. doi: 10.1016/j.amjcard.2010.09.039.
  12. Papa A, Emdin M, Passino C, et al. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clin Chim Acta. 2008 Sep;395(1-2):27-31. PMID: 18498767. doi: 10.1016/j.cca.2008.04.019.
  13. Сперанский И.И., Самойленко Г.Е., Лобачева М.В. Общий анализ крови - все ли его возможности исчерпаны? Интегральные индексы интоксикации как критерии оценки тяжести течения эндогенной интоксикации, ее осложнений и эффективности проводимого лечения. Здоровье Украины. 2009; 6 (19): 51-57
  14. Кобец Т. В., Кобец Ю. В., Гавриков И. В. Применение современных информационных технологий для оценки эффективности лечения на курорте // Молодой ученый. 2016; 5: 219-221.

Copyright (c) 2017 Bakhchoyan M.R., Kosmacheva E.D., Slavinsky A.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies