KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection
- Authors: Brovkina O.I.1, Nikitin A.G.1
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Affiliations:
- Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia
- Issue: Vol 12, No 1 (2021)
- Pages: 66-71
- Section: Reviews
- URL: https://journals.rcsi.science/clinpractice/article/view/63875
- DOI: https://doi.org/10.17816/clinpract63875
- ID: 63875
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Abstract
Determination of the mutations' status in the KRAS and NRAS genes is a necessary requirement in the treatment of patients with colorectal cancer (CRC). Patients with certain mutations in the KRAS and NRAS genes are resistant to anti-EGFR drug therapy and have a lower median survival rate than those with WT (wild type) genotypes, that indicates a negative prognosis in the case when mutations are present. Currently, there are no registered targeted drugs for carriers of the KRAS and NRAS genes mutations, however, preparations based on small molecules are under way. The gold standard for detecting mutations in the KRAS and NRAS genes is the analysis of the biopsy material in paraffin blocks. However, this method has significant limitations that can be circumvented by the analysis of circulating tumor DNA — a promising new method in the diagnosis of colorectal cancer.
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##article.viewOnOriginalSite##About the authors
Olga I. Brovkina
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia
Email: brov.olia@gmail.com
ORCID iD: 0000-0002-0946-7331
SPIN-code: 3631-1397
Cand. Sci. (Biol.)
Russian Federation, 28, Orekhovy boulevard, Moscow, 115682Alexey G. Nikitin
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia
Author for correspondence.
Email: avialn@gmail.com
ORCID iD: 0000-0001-9762-3383
SPIN-code: 3367-0680
Cand. Sci. (Biol.)
Russian Federation, 28, Orekhovy boulevard, Moscow, 115682References
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