Five-year result of Microvascular decompression using video endoscopy in the treatment of classic trigeminal neuralgia with paroxysmal pain syndrome

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Abstract

Background. The incidence of trigeminal neuralgia (TN) is 15 per 100,000 people per year. The effectiveness of the existing conservative methods of therapy does not exceed 50%. At the same time, the use of carbamazepine doubles the frequency of depressive conditions, and by 40% increases the incidence of suicidal thoughts. Microvascular decompression (MVD) of the trigeminal root is a"gold standard" treatment for patients with facial pain, however, due to the lack of awareness of the disease, not all the patients receive the adequate therapy timely. Aims: to evaluate the long-term results of video endoscopy-assisted microvascular decompression in the treatment of patients with classical trigeminal neuralgia (cNTN) with paroxysmal facial pain. Methods. In the period from 2014 to 2019, 62 patients were operated for classic NTN and paroxysmal facial pain. The average period from the onset of pain syndrome to surgery was 5 years (from 2 months to 15 years). All the patients in the preoperative period underwent conservative therapy (carbamazepine, gabapentin, pregabalin), which was not accompanied by significant pain reduction. Two (3%) patients had previously undergone a radiosurgical treatment using the Gamma Knife device, and 7 (11%) patients had an analgesic blockade without an effect at other hospitals. The maximum pain intensity upon the admission to the hospital, according to the visual analogue scale (VAS,) was 10 points, according to the BNI (Barrow Neurological Institute) pain syndrome scale — V. All the patients underwent MVD of the trigeminal nerve root using Teflon, and video endoscopic assistance during surgery was used in 9 patients . The average follow-up period after the surgery was 3.4 ± 1.7 years (from 1 to 5 years). Results. In all (100%) the patients, the pain was completely relieved after the surgery (BNI I). Excellent and good results after MVD within 5 years were achieved in 97% of patients (BNI I–II). Facial hypesthesia, not causing discomfort and anxiety (BNI II), developed in 5 (8.1%) patients. The use of video endoscopy made it possible to identify the vessels compressing the trigeminal nerve root with a minimal traction of the cerebellum and cranial nerves. The development of cerebellar edema and ischemia occurred in one (1.6%) patient operated without the application of video endoscopy. Conclusion. The MVD method with video endoscopy is effective in the treatment of patients with cNTN with paroxysmal pain syndrome.

About the authors

Aleksey G. Vinokurov

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia

Email: avinok@yandex.ru

MD, PhD

Russian Federation, Moscow

Aleksander A. Kalinkin

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia

Author for correspondence.
Email: aleksandr_kalinkin27@mail.ru
ORCID iD: 0000-0002-1605-9088
SPIN-code: 9919-5834

MD, PhD

Russian Federation, Moscow

Andrey А. Bocharov

Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia

Email: avinok@yandex.ru
ORCID iD: 0000-0001-8970-3762

MD, PhD

Russian Federation, Moscow

Olga N. Kalinkina

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: avinok@yandex.ru

MD

Russian Federation, Moscow

References

  1. Гречко В.Е., Степанченко А.В., Шаров М.Н. К вопросу о патогенезе истинной тригеминальной невралгии // Неврологический вестник. Журнал имени В.М. Бехтерева. — 2001. — Т.33. — №1-2. — С. 56–59. [Grechko VE, Stepanchenko AV, Sharov MN. On the pathogenesis of true trigeminal neurology. Neurological bulletin. Named after V.M.bekhterev. 2001;33(1-2):56–59. (In Russ).]
  2. Toledo IP, Conti Réus J, Fernandes M, et al. De Prevalence of trigeminal neuralgia: A systematic review. J Am Dent Assoc. 2016;147(7):570–576. doi: 10.1016/j.adaj.2016.02.014.
  3. Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G. Trigeminal neuralgia — diagnosis and treatment. Cephalalgia. 2017;37:648–657. doi: 10.1177/0333102416687280.
  4. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1–211. doi: 10.1177/0333102417738202.
  5. Zakrzewska JM, Lopez BC. Quality of reporting in evaluations of surgical treatment of trigeminal neuralgia: recommendations for future reports. Neurosurgery. 2003;53:110–20. doi: 10.1227/01.neu.0000068862.78930.
  6. Di Stefano G, La Cesa S, Truini A, Cruccu G. Natural history and outcome of 200 outpatients with classical trigeminal neuralgia treated with carbamazepine or oxcarbazepine in a tertiary centre for neuropathic pain. J Headache Pain. 2014;15(1):34. doi: 10.1186/1129-2377-15-34.
  7. Obermann M, Yoon MS, Ese D, et al. Impaired trigeminal nociceptive processing in patients with trigeminal neuralgia. Neurology. 2007;69:835–841. doi: 10.1212/01.wnl.0000269670.30045.6b.
  8. Yarushkina NI, Bagaeva TR, Filaretova LP. Central corticotropin-releasing factor (CRF) may attenuate somatic pain sensitivity through involvement of glucocorticoids. J Physiol Pharmacol. 2011;62(5):541– 548.
  9. Рзаев Д.А. Дифференцированное хирургическое лечение лицевой боли: автореф. дис. … докт. мед. наук. — М., 2018. — 51 с. [Rzaev D.A. Differentsirovannoe khirurgicheskoe lechenie litsevoi boli. [dissertation abstract] Moscow; 2018. 51 р. (In Russ).]
  10. Pereira A, Gitlin MJ, Gross RA, et al. Suicidality associated with antiepileptic drugs: Implications for the treatment of neuropathic pain and fibromyalgia. Pain. 2013;154: 345–349. doi: 10.1016/j.pain.2012.12.024.
  11. Cruccu G, Gronseth G, Alksne J, et al. AAN-EFNS guidelines on trigeminal neuralgia management. Eur J Neurol. 2008;15(10):1013–1028. doi: 10.1111/j.1468-1331.2008.02185.x.
  12. Ghosh LM, Dubey SP. The syndrome of elongated styloid process. Auris Nasus Larynx. 1999;26(2):169–175. doi: 10.1016/s0385-8146(98)00079-0.
  13. Шиманский В.Н., Коновалов А.Н., Пошатаев В.К. Васкулярная декомпрессия при гиперфункции черепных нервов (невралгия тройничного нерва, гемифациальный спазм, невралгия языкоглоточного нерва). — М.: ИП Т.А. Алексеева, 2017. — С. 11–12. [Shimansky VN, Konovalov AN, Poshataev VK. Vascular decompression in cranial nerve hyperfunction (trigeminal neuralgia, hemifacial spasm, lingual nerve neuralgia). Moscow: IP T.A. Alekseeva; 2017. P. 11–12. (In Russ).]
  14. Krause F. Resection des Trigeminus innerhalb der Schadelhohle. Arch Klin Chir. 1892;44:821–832.
  15. Dandy WE. An operation for the cure of tic douloureux: partial section of the sensory root at the pons. Arch Surg. 1929:18(2):687. doi: 10.1001/archsurg.1929.04420030081005.
  16. Magendie F. Textbook of Physiologie. 1822.
  17. Bell Sir Charles. The Nervous System. Ed. 3. London, 1844.
  18. Jannetta PJ. Arterial compression of the trigeminal nerve at the pons in patients with trigeminal neuralgia. J Neurosurg. 1967;26(2):159. doi: 10.3171/jns.1967.26.1part2.0159.
  19. Dandy WE. The treatment of trigeminal neuralgia by the cerebellar route. Ann Surg. 1932;96(4):787–795. doi: 10.1097/00000658-193210000-00026.
  20. Мартынова О.А. Патофизиологические механизмы развития тригеминальной невралгии как проявления нейроваскулярной компрессии Современные подходы к лечению // Вестник совета молодых учёных и специалистов Челябинской области. — 2017. — №4. — С. 82–85. [Martynova OA. Pathophysiological mechanisms of the development of trigeminal neuralgia as manifestations of neurovascular compression. Bulletin of the Council of Young Scientists and Specialists of the Chelyabinsk Region. 2017;(4):82–85. (In Russ).]
  21. Devor M, Amir R, Rappaport ZH. Pathophysiology of trigeminal neuralgia: The ignition hypothesis. Clin J Pain. 2002;18:4–13. doi: 10.1097/00002508-200201000-00002.
  22. De Simone R, Marano E, Brescia Morra V, et al. A clinical comparison of trigeminal neuralgic pain in patients with and without underlying multiple sclerosis. Neurol Sci. 2005;26(2):150–151. doi: 10.1007/s10072-005-0431-8.
  23. Maarbjerg S, Gozalov A, Olesen J. Trigeminal neuralgia — a prospective systematic study of clinical characteristics in 158 patients. Headache. 2014;54:1574–1582. doi: 10.1111/head.12441.
  24. Jannetta PJ, Bissonette DJ. Management of the failed patient with trigeminal neuralgia. Clin Neurosurg. 1985;32:334–347.
  25. Pressman E, Jha RT, Zavadskiy G, et al. Teflon™ or Ivalon®: a scoping review of implants used in microvascular decompression for trigeminal neuralgia. Neurosurg Rev. 2020;43(1):79–86. doi: 10.1007/s10143-019-01187-0.
  26. Capelle HH, Brandis A, Tschan CA, Krauss JK. Treatment of recurrent trigeminal neuralgia due to Teflon granuloma. J Headache Pain. 2010;11(4):339–344. doi: 10.1007/s10194-010-0213-4.
  27. Gu W, Zhao W. Microvascular decompression for recurrent trigeminal neuralgia. J Clin Neurosci. 2014;21:1549–1553. doi: 10.1016/j.jocn.2013.11.042.
  28. Zhong J, Shi-Ting Li, Zhu J, et al. A clinical analysis on microvascular decompression surgery in a series of 3000 cases. Clin Neurol Neurosurg. 2012;114(7):846–851. doi: 10.1016/j.clineuro.2012.01.021.

Supplementary files

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2. Fig. 1. Patient M. with trigeminal neuralgia: magnetic resonance imaging of the brain in FIESTA mode

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3. Fig. 2. Patient M. with trigeminal neuralgia: stages of microvascular decompression and postoperative computed tomography images

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Copyright (c) 2020 Vinokurov A.G., Kalinkin A.A., Bocharov A.А., Kalinkina O.N.

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