Induced blood oxidation in myocardial revascularization
- Authors: Shereshneva M.V.1, Ilyin M.V.1, Sandugey A.V.1, Zotov A.S.2
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Affiliations:
- Yaroslavl State Medical University
- Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency
- Issue: Vol 13, No 2 (2022)
- Pages: 20-28
- Section: Original Study Articles
- URL: https://journals.rcsi.science/clinpractice/article/view/107847
- DOI: https://doi.org/10.17816/clinpract107847
- ID: 107847
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Abstract
Background: The use of artificial circulation in surgical myocardial revascularization is one of the key pathogenetic factors in the development of the oxidative stress and systemic inflammatory response in the postoperative period. Aims: the purpose of the study was to describe the dynamics of the induced blood oxidation parameters during coronary artery bypass surgery in the conditions of artificial circulation and on the working heart. Methods: The study included 64 patients who underwent coronary bypass surgery, with 31 (48.4%) on-pump patients and 33 (51.6%) off-pump patients. The oxidative stress simulations were conducted under the in vitro conditions. The blood oxidation-induced values were studied using a biological oxygen monitor. Results: In patients with coronary heart disease, regardless of the choice of the revascularization method (on-pump / off-pump), we observed statistically significantly (p <0.05) higher initial and maximum blood oxidation rates, the oxidative activity factor, and a shorter initiation period than those in healthy volunteers. No significant differences were found by the inter-group comparison analysis both 10 days and 6 months post-surgery. Conclusion: The indicators of induced blood oxidation do not depend on the method of revascularization during coronary bypass grafting (artificial circulation or a working heart). The changes in the parameters indicating activation of the oxidative and antioxidant blood systems may be transient by their nature and occur in the early postoperative period.
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##article.viewOnOriginalSite##About the authors
Marina V. Shereshneva
Yaroslavl State Medical University
Author for correspondence.
Email: m.shereshneva@yandex.ru
ORCID iD: 0000-0002-5362-8702
SPIN-code: 3521-7810
Russian Federation, Yaroslavl
Mikhail V. Ilyin
Yaroslavl State Medical University
Email: dekanat-2011@mail.ru
ORCID iD: 0000-0001-6278-374X
SPIN-code: 2936-4312
МD, PhD, Associate Professor
Russian Federation, YaroslavlAnna V. Sandugey
Yaroslavl State Medical University
Email: sandugey1@yandex.ru
ORCID iD: 0000-0001-5219-2145
SPIN-code: 3806-1033
МD, PhD, Assistent
Russian Federation, YaroslavlAlexander S. Zotov
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency
Email: zotov.alex.az@gmail.com
ORCID iD: 0000-0003-2385-7456
SPIN-code: 9315-6570
МD, PhD
Russian Federation, MoscowReferences
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