Aging and “rejuvenation” of resident stem cells — a new way to active longevity?
- Authors: Baklaushev V.P.1,2,3, Samoilova E.M.1,2, Kalsin V.A.1,2, Yusubalieva G.M.1,2
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Affiliations:
- Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency
- Engelhardt Institute of Molecular Biology
- Pulmonology Scientific Research Institute under Federal Medical and Biological Agency of Russian Federation
- Issue: Vol 13, No 1 (2022)
- Pages: 79-91
- Section: Reviews
- URL: https://journals.rcsi.science/clinpractice/article/view/104999
- DOI: https://doi.org/10.17816/clinpract104999
- ID: 104999
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Abstract
This review presents the current data on the methodology for assessing the biological and epigenetic age, describes the concept of the epigenetic clock, and characterizes the main types of resident stem cells and the specifics of their aging. It has been shown that age-related changes in organs and tissues, as well as age-related diseases, are largely due to the aging of resident stem cells. The latter represent an attractive target for cell rejuvenation, as they can be isolated, cultured ex vivo, modified, and re-introduced into the resident niches. Two main methodologies for the cellular rejuvenation are presented: genetic reprogramming with «zeroing» the age of a cell using transient expression of transcription factors, and various approaches to epigenetic rejuvenation. The close relationship between aging, regeneration, and oncogenesis, and between these factors and the functioning of resident stem cell niches requires further precision studies, which, we are sure, can result in the creation of an effective anti-aging strategy and prolongation of human active life.
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##article.viewOnOriginalSite##About the authors
Vladimir P. Baklaushev
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency; Engelhardt Institute of Molecular Biology; Pulmonology Scientific Research Institute under Federal Medical and Biological Agency of Russian Federation
Email: baklaushev.vp@fnkc-fmba.ru
ORCID iD: 0000-0003-1039-4245
SPIN-code: 3968-2971
https://fnkc-fmba.ru/about/komanda-upravleniya/
MD, PhD, Chief Scientific Officer
Russian Federation, 28, Orekhovy blvd, Moscow, 115682; Moscow; MoscowEkaterina M. Samoilova
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency; Engelhardt Institute of Molecular Biology
Email: samoyket@gmail.com
ORCID iD: 0000-0002-0485-6581
SPIN-code: 3014-6243
MD
Russian Federation, 28, Orekhovy blvd, Moscow, 115682; MoscowVladimir A. Kalsin
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency; Engelhardt Institute of Molecular Biology
Author for correspondence.
Email: vkalsin@mail.ru
ORCID iD: 0000-0003-2705-3578
SPIN-code: 1046-8801
научный сотрудник лаборатории клеточных технологий
Russian Federation, 28, Orekhovy blvd, Moscow, 115682; MoscowGaukhar M. Yusubalieva
Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency; Engelhardt Institute of Molecular Biology
Email: gaukhar@gaukhar.org
ORCID iD: 0000-0003-3056-4889
SPIN-code: 1559-5866
MD, PhD
Russian Federation, 28, Orekhovy blvd, Moscow, 115682; MoscowReferences
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