电邮这篇文章 Genetic predictors regarding of infection-dependent pregnancy loss
- 作者: Tsechoeva L.S.1,2, Dementyeva E.I.2, Leonova M.D.3, Poloskov A.I.4, Gavrichkova Y.V.5, Tapil'skaya N.I.6, Glushakov R.I.3
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隶属关系:
- I. I. Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine
- Saint Petersburg State Pediatric Medical University
- Maternity Hospital N 13
- Military Medical Academy
- City Mariinsky Hospital
- Ott Research institute of obstetrics, gynecology and reproductology
- 期: 卷 42, 编号 2 (2023)
- 页面: 185-195
- 栏目: Reviews
- URL: https://journals.rcsi.science/RMMArep/article/view/316033
- DOI: https://doi.org/10.17816/rmmar162014
- ID: 316033
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A retrospective comparative cohort study investigated the prevalence of genetic variants are associated with immune hyper-response of the immune system in women (n = 96) with a history of infected miscarriage. The comparison groups subjects was 76 women of the same age with 2 or more normal pregnancies in history.
The frequency of gene polymorphism in patients in all patients of the main group and the comparison group: the G894T polymorphism (Glu298Asp, rs1799983) of the Nos3 gene, the C1234T (p.Leu412Phe, rs3775291) polymorphism of the Tlr3 gene, the C3954T (rs1143644) and C-511T (rs16944) polymorphisms of the IL1B gene, and G-308A (rs1800629) and G238A (rs361525) of the Tnf gene. For comparative statistical analysis, we used the chi-square test and Fisher’s exact test with the determination of relative risk and confidence interval (CI).
Comparative analysis showed that polymorphism in defined gene was associated with an increased the relative risk of infected miscarriage: T/T genotype of the Tlr3 gene (C1234T), the C allele of the Il1b gene (C3954T), and the A allele of the Tnf gene (G238A) increases the relative risk of infected miscarriage by 3.345 times (95% confidence interval 1.594–7.017; chi-square test = 10.779, p = 0.002), 5.077 times (95% confidence interval 2.743–9.396; chi-square test = 30.272, p < 0.001) and 2.958 times (95% confidence interval 1.451–6.032; chi-square test = 9.533, p = 0.003), respectively.
作者简介
Leila Tsechoeva
I. I. Dzhanelidze Saint Petersburg Research Institute of Emergency Medicine; Saint Petersburg State Pediatric Medical University
Email: doctor-leila@yandex.ru
SPIN 代码: 9248-9806
M.D., Ph.D. (Medicine), the Head of division of gynecology
俄罗斯联邦, Saint Petersburg; Saint PetersburgElena Dementyeva
Saint Petersburg State Pediatric Medical University
Email: 02102005@bk.ru
M.D., doctor – obstetrician-gynecologist
俄罗斯联邦, Saint PetersburgMargarita Leonova
Maternity Hospital N 13
Email: margarita_@bk.ru
ORCID iD: 0000-0002-3813-2995
SPIN 代码: 8158-4744
M.D., doctor – obstetrician-gynecologist, the Head of the Maternity Department
俄罗斯联邦, Saint PetersburgAnton Poloskov
Military Medical Academy
Email: a.i.poloskov@gmail.com
SPIN 代码: 3465-2522
junior researcher of the department (Medical and Biological Research) of the Research Center
俄罗斯联邦, Saint PetersburgYuliya Gavrichkova
City Mariinsky Hospital
Email: ignatenkoiuliia@gmail.com
M.D., doctor – obstetrician-gynecologist, gynecological department №2
俄罗斯联邦, Saint PetersburgNatalya Tapil'skaya
Ott Research institute of obstetrics, gynecology and reproductology
Email: tapnatalia@yandex.ru
ORCID iD: 0000-0001-5309-0087
SPIN 代码: 3605-0413
M.D., D.Sc. (Medicine), Professor, Professor of the Obstetrics and Gynecology Department; the Head of Reproductology Department
俄罗斯联邦, Saint PetersburgRuslan Glushakov
Maternity Hospital N 13
编辑信件的主要联系方式.
Email: glushakoffruslan@yandex.ru
ORCID iD: 0000-0002-0161-5977
SPIN 代码: 6860-8990
M.D., D.Sc. (Medicine), the Head of the Department (medical and biological research) of the Research Center
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