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Post a Comment The administration of acetazolamidum for the symptom prophylaxis of an acute mountain sickness when short-term dislocation from middle mountains to highlands takes place
- Authors: Vetryakov O.V.1, Bykov V.N.2, Fateev I.V.2, Khalimov Y.S.1
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Affiliations:
- S.M. Kirov Military Medical Academy
- State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
- Issue: Vol 16, No 2 (2018)
- Pages: 42-48
- Section: Articles
- URL: https://journals.rcsi.science/RCF/article/view/9164
- DOI: https://doi.org/10.17816/RCF16242-48
- ID: 9164
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Abstract
The development of mountain sickness symptoms is one of the limiting factors of successful physical performance in middle mountains and highlands. Among drugs with established effectiveness for the prophylaxis of an acute mountain sickness carbonic anhydrase inhibitor acetazolamidum is also viewed, but at presence there is no universal approach to this issue and drug dosage regimen for its administration have not been elaborated.
Aim. А comprehensive analysis of acetazolamidum being administered in the range of effective doses has been carried out.
Methods. During the experiment the effect of acetazolamidum on physical performance and resistance of rats to an acute hypobaric hypoxia when administered in the range of effective doses (20, 40 and 80 mg/kg) was studied. During full-scale approbation the effect of acetazolamidum in various dosages on adaptation processes in the course of a rapid dislocation from middle mountains to highlands (glade Azau-the Elbrus mountain) was assessed.
Results. The undertaken study showed that the administration of acetazolamidum to rats beginning from a daily do sage 20 mg/kg, that corresponds to human intake of 250 mg of the drug, promotes significant increase of survival time of rats following acute hypoxic exposure as well as growth of an animal performance ability factor under hypoxia.
Conclusion. In the course of full-scale approbation it was established that prophylactic intake of acetazolamidum in examined doses prevents the development of symptoms of an acute mountain sickness when rapid dislocation from middle mountains (2300 m) to highlands (5000 m) takes place in the background of physical activity according to the results of sportsmen’s performance of Lake Louise test.
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##article.viewOnOriginalSite##About the authors
Oleg V. Vetryakov
S.M. Kirov Military Medical Academy
Author for correspondence.
Email: o.v.vetryakov@mail.ru
Candidate of Medicine, Lecturer of the Department of Military Field Therapy
Russian Federation, St. PetersburgVladimir N. Bykov
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: bykov_imm@yahoo.com
Doctor of Medicine, Professor, Deputy Head for Scientific Work
Russian Federation, St. PetersburgIvan V. Fateev
State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation
Email: ivvf@mail.ru
Candidate of Medicine, Deputy Head of Department in Research and Testing Center
Russian Federation, St. PetersburgYuriy Sh. Khalimov
S.M. Kirov Military Medical Academy
Email: yushkha@gmail.com
Doctor of Medicine, Professor, Head of the Department of Military Therapy
Russian Federation, St. PetersburgReferences
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