Neurochemical mechanisms and pharmacology of ghrelins
- Authors: Shabanov P.D.1,2, Lebedev A.A.1, Bychkov E.R.1, Lavrov N.V.3, Morozov V.I.1
-
Affiliations:
- Institute of Experimental Medicine
- S.M. Kirov Military Medical Academy
- St. Petersburg State Pediatric Medical University
- Issue: Vol 18, No 1 (2020)
- Pages: 5-22
- Section: Reviews
- URL: https://journals.rcsi.science/RCF/article/view/34058
- DOI: https://doi.org/10.17816/RCF1815-22
- ID: 34058
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Abstract
The purpose of the review was to analyze the neurochemical and neurophysiological mechanisms of the ghrelin system and the role of ghrelin in body functions and behavior. The focus is on the participation of ghrelin in the mechanisms of reinforcement and the formation of addictive behavior. At the beginning of the review a history of the first works on the field of ghrelin and its receptor was described. Then, genetic control, molecular precursor of ghrelin, molecular forms of ghrelin and ghrelin receptor were represented. In particular, the distribution of the ghrelin receptor, ghrelin-producing cells in the brain and its participation in various physiological functions of the body were shown. The hypothalamic functions of ghrelin were discussed: energy balance, regulation of glucose metabolism, stimulation of eating behavior, regulation of hypophys-pituitary axis (HPA) system. The connection of ghrelin with the brain CRH system was demonstrated. In particular, activation of HPA was described as a possible mechanism through which ghrelin regulates a number of physiological processes. Extrahypothalamic action of ghrelin was shown on the basis of the mechanisms of reinforcement and addiction. On the basis of their own data and literary, it was concluded that action of alcohol and psychoactive drugs are reduced after the ghrelin receptors blockade. In particular, it has been demonstrated that alcoholization of mothers affects the activity of the ghrelin system during the prenatal and early postnatal periods of development in the offspring of rats. It was shown the participation of ghrelin in memory and learning. The further perspective of the study and practical application of ghrelin-based pharmacological agents was analyzed.
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##article.viewOnOriginalSite##About the authors
Petr D. Shabanov
Institute of Experimental Medicine; S.M. Kirov Military Medical Academy
Author for correspondence.
Email: pdshabanov@mail.ru
Dr. Med. Sci. (Pharmacology), Professor and Head, Dept. of Neuropharmacology; Head, Department of Pharmacology
Russian Federation, Saint PetersburgAndrei A. Lebedev
Institute of Experimental Medicine
Email: aalebedev-iem@rambler.ru
Dr. Biol. Sci. (Pharmacology), Head of the Laboratory of General Pharmacology, Dept. of Neuropharmacology
Russian Federation, Saint PetersburgEugenii R. Bychkov
Institute of Experimental Medicine
Email: bychkov@mail.ru
PhD (Pathophysiology), Head of the Laboratory of Chemistry and Pharmacology of Medicinal Compounds, Dept. of Neuropharmacology
Russian Federation, Saint PetersburgNikanor V. Lavrov
St. Petersburg State Pediatric Medical University
Email: nikanlavr@rambler.ru
PhD (Pharmacology), Assistant Professor, Dept. оf Pharmacology
Russian Federation, Saint PetersburgVitalii I. Morozov
Institute of Experimental Medicine
Email: vitmoroz@yandex.ru
PhD (Narcology), Postdoc Student, Dept. of Neuropharmacology
Russian Federation, Saint PetersburgReferences
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