Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds
- Authors: Urakov A.L.1, Urakova N.A.1, Reshetnikov A.P.1, Shabanov P.D.2, Wang Y.3, Bodduluri P.V.4, Samorodov A.V.5, Rozov R.A.6, Shchemeleva A.A.1, Novikov V.E.7, Pozhilova E.V.7
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Affiliations:
- Izhevsk State Medical Academy
- Institute of Experimental Medicine
- Hangzhou Normal University
- Kravy Pharma Institute
- Bashkir State Medical University
- Academician I.P. Pavlov First St. Petersburg State Medical University
- Smolensk State Medical University
- Issue: Vol 21, No 4 (2023)
- Pages: 287-297
- Section: Reviews
- URL: https://journals.rcsi.science/RCF/article/view/251924
- DOI: https://doi.org/10.17816/RCF606648
- ID: 251924
Cite item
Abstract
The traditional treatment of chronic wounds involves daily cleansing of the wound surface from purulent necrotic masses using mechanical and medicinal methods, accompanied by regular replacement of wound dressing. In this case, medicinal wound cleansing lasts 10–15 mins from the time of replacement of the old wound dressing with the new one. According to established practice, medicinal sanitation of infected and purulent wounds during dressing involves irrigation of the wound surface with cleansing solutions, antiseptics, and/or antibiotics. In severe cases, the above therapy is supplemented with live larvae of the necrophage fly, which are injected into purulent necrotic masses and left in them under wound dressing until wounds are completely cleansed from pus. Nevertheless, the generally accepted course of treatment of chronic wounds remains ineffective. The use of pyolytics and their supplementation with wound dressings in the form of warm wet compresses, which create a local greenhouse effect in wounds, was reported to accelerate the healing of chronic wounds. Pyolytics are a group of antiseptics developed in Russia. They are warm alkaline solutions of hydrogen peroxide; when they interact with purulent necrotic masses, these solutions dissolve very quickly and foam them. Because of the interaction with pyolytics, thick purulent masses immediately turn into fluffy oxygenated foam. Pyolytics have been developed because of the physicochemical repurposing of aqueous solutions of sodium hydrogen carbonate and hydrogen peroxide. To accelerate the healing of chronic wounds, a recommendation was to irrigate the surface of chronic wounds with 3% hydrogen peroxide and 2–10% sodium bicarbonate solutions, heated to 37–45°C, which have alkaline activity at pH 8.4–8.5 and are enriched with dissolved carbon dioxide or oxygen (due to excess pressure of 0.2 atm). This study presented the importance of treating chronic wounds using politics and treatment outcomes using pyolytics along with warm moist dressing compresses, demonstrating a wound-healing effect. Consequently, physical and chemical reprofiling of antiseptics may make them effective pyolytics, and the combination of pyolytics with warm wound dressings such as warm moist compresses, which create a local greenhouse effect on wounds, accelerates the healing of chronic wounds.
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##article.viewOnOriginalSite##About the authors
Aleksandr L. Urakov
Izhevsk State Medical Academy
Author for correspondence.
Email: urakoval@live.ru
ORCID iD: 0000-0002-9829-9463
SPIN-code: 1613-9660
MD, Dr. Sci. (Medicine), Professor
Russian Federation, IzhevskNatalia A. Urakova
Izhevsk State Medical Academy
Email: urakovanatal@mail.ru
ORCID iD: 0000-0002-4233-9550
SPIN-code: 4858-1896
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, IzhevskAlexey P. Reshetnikov
Izhevsk State Medical Academy
Email: areshetnikov@list.ru
ORCID iD: 0000-0002-8710-9724
SPIN-code: 4115-4167
MD, Cand. Sci. (Medicine)
Russian Federation, IzhevskPetr D. Shabanov
Institute of Experimental Medicine
Email: pdshabanov@mail.ru
ORCID iD: 0000-0003-1464-1127
SPIN-code: 8974-7477
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgYi Wang
Hangzhou Normal University
Email: yi.wang1122@wmu.edu.cn
ORCID iD: 0000-0001-9048-0092
Scopus Author ID: 55969091300
MD, PhD, Professor
Taiwan, Province of China, HangzhouPradeep Vishwanath Bodduluri
Kravy Pharma Institute
Email: Pradeep.bodduluri@gmail.com
ORCID iD: 0000-0002-7584-182X
India, Hyderabad
Aleksandr V. Samorodov
Bashkir State Medical University
Email: avsamorodov@gmail.com
ORCID iD: 0000-0001-9302-499X
SPIN-code: 2396-1934
MD, Dr. Sci. (Medicine), Assistant Professor
Russian Federation, UfaRoman A. Rozov
Academician I.P. Pavlov First St. Petersburg State Medical University
Email: dr.rozov@gmail.com
ORCID iD: 0000-0001-5804-9497
SPIN-code: 1173-7870
MD, Dr. Sci. (Med.), Assistant Professor
Russian Federation, Saint PetersburgAlbina A. Shchemeleva
Izhevsk State Medical Academy
Email: redbild@mail.ru
ORCID iD: 0000-0001-7771-8772
SPIN-code: 2126-0259
MD, Cand. Sci. (Medicine)
Russian Federation, IzhevskVasiliy E. Novikov
Smolensk State Medical University
Email: novikov.farm@yandex.ru
ORCID iD: 0000-0002-0953-7993
SPIN-code: 1685-1028
MD, Dr. Sci. (Medicine), Professor
Russian Federation, SmolenskElena V. Pozhilova
Smolensk State Medical University
Email: elena-pozh2008@yandex.ru
ORCID iD: 0000-0002-7372-7329
SPIN-code: 6371-6930
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, SmolenskReferences
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