Why do we need fullerenes today?

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Abstract

The review focuses on the possibilities and prospects of the use of fullerenes and their derivatives in cosmetics, the only industrial area where fullerenes have found practical application today. Based on the literary data and the results of their own experiments, the authors substantiate the safety of using fullerene for living organisms, as well as the usefulness of introducing fullerene as antioxidant in cosmetic compositions. Other useful properties of fullerene used in cosmetics and dermatology are discussed.

About the authors

Levon B. Piotrovsky

Institute of Experimental Medicine

Author for correspondence.
Email: levon-piotrovsky@yandex.ru

Dr. Biol. Sci., Professor, Head, Laboratory of Synthesis and Nanothechnology of Drugs

Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

Elena V. Litasova

Institute of Experimental Medicine

Email: llitasova@mail.ru

PhD (Biology), Senior Researcher, Laboratory of Synthesis and Nanothechnology of Drugs

Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

Marina A. Dumpis

Institute of Experimental Medicine

Email: mardoom@mail.ru

PhD (Chemistry), Leading Researcher, Laboratory of Synthesis and Nanothechnology of Drugs

Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

References

  1. Jones DE. Daedalus. New Scientist. 1986;110:80.
  2. Osawa E. Superaromaticity. Kogaku. 1970;25:854-863.
  3. Бочвар А.A., Гальперин Е.Г. О гипотетических системах: карбододекаэдре, s-икосаэдране и карбо-s-икосаэдре // Доклады академии наук СССР. – 1973. – Т. 209. – С. 610–612. [Bochvar AА, Galpern EG. About hypothetical systems: carbododecahedro, s-icosahedron and carbo-s-icosahedron. Dokl Akad Nauk SSSR. 1973;209:610-612. (In Russ.)]
  4. Kroto HW, Heath S, O’Brien SC, et al. C60: Buckminsterfullerene. Nature. 1985;318:162-163. https://doi.org/10.1038/318162a0.
  5. Kroto HW, Allaf AW, Balm P. C60: Buckminsterfullerene. Chem Rev. 1991;91:1213-1235. https://doi.org/10.1021/cr00006a005.
  6. Curl RF, Smalley RE, Kroto HW, et al. How the news that we were not the first to conceive of soccer ball C60 got to us. J Mol Grap Modell. 2001;19:185-186. https://doi.org/:10.1016/s1093-3263(00)00107-8.
  7. Kroto HW. Symmetry, space, stars, and C60 (Nobel lecture). Angew Chem Int Ed. 1997;36:1578-1593. https://doi.org/10.1002/anie.199715781.
  8. Википедия [интернет]. Доступно по: https://ru.wikipedia.org/wiki/Серендипность (serendipity). Ссылка активна на 15.02.2019.
  9. Кац Е.А. Фуллерены, углеродные нанотрубки и нанокластеры. Родословная форм и идей. – Серия «Науку — всем! Шедевры научно-популярной литературы». – М.: Либроком, 2019. – 294 с. [Katz EA. Fullerenes, carbon nanotubes and nanoclusters. Genealogy of forms and ideas. Seriya “Nauku – vsem! Shedevry nauchno-populyarnoi literatury”. Moscow: Librokom; 2019. 294 p. (In Russ.)]
  10. Kratschmer W, Lamb LD, Fostiropoulos K, Huffman DR. Solid C60: a new form of carbon. Nature. 1990;347:354-358. https://doi.org/10.1038/347354a0.
  11. Braun T, Schubert A, Kostoff RN. A chemistry field in search of applications statistical analysis of U.S. fullerene patents. J Chem Inf Comput Sci. 2002;42(5):1011-1015. https://doi.org/10.1021/ci0200117.
  12. Penkova AV, Acquah SF, Piotrovskiy LB, et al. Fullerene derivatives as nano-additives in polymer composites. Russ Chem Rev. 2017;86(6):530-566. https://doi.org/10.1070/RCR4712.
  13. Hoffmann R. Thoughts on aesthetics and visualization in chemistry. Int J Phyl Chem. 2003;9:7-10. https://doi.org/10.1504/IJCRC.2016.076058.
  14. Svetla активирована фуллеренами [интернет]. Доступно по: http://svetla.com/ru/. Ссылка активна на 15.02.2019.
  15. Свердлов Е.Д. Берегись! Высокий импакт-фактор [электронная библиотечная система] // Вестник Российской академии наук. – 2018. – Т. 88. – № 6. – С. 531–538. [Sverdlov ED. Attention! High impact factor [elektronnaya bibliotechnaya sistema]. Vestnik Rossijskoi akademii nauk. 2018;88(6):531-538. (In Russ.)]. https://doi.org/10.7868/S0869587318060063.
  16. Mousavi SZ, Nafisi S, Maibach HI. Fullerene nanoparticle in dermatological and cosmetic applications. Nanomedicine: nanotechnology, biology, and medicine. 2017;13:1071-1087. https://doi.org/10.1016/j.nano.2016.10.002.
  17. Пиотровский Л.Б., Киселев О.И. Фуллерены в биологии. – СПб.: Росток, 2006. – 334 с. [Piotrovskiy LB, Kiselev OI. Fullerenes in biology. Saint Petersburg: Rostock; 2006. 334 p. (In Russ.)]
  18. Пиотровский Л.Б. Фуллерены в дизайне лекарственных веществ // Российские нанотехнологии. – 2007. – Т. 2. – № 7–8. – С. 6–18. [Piotrovsky LB. Fullerenes in drug design. Nanotechnologies in Russia. 2007;2(7-8):6-18. (In Russ.)]
  19. Semenov KN, Andrusenko EV, Charykov NA, et al. Carboxylated fullerenes: physico-chemical properties and potential applications. Progress in Solid State Chemistry. 2017;(47-48):19-36. https://doi.org/10.1016/j.progsolidstchem.2017.09.001.
  20. Piotrovsky LB. Biological activity of pristine fullerene C60 // Carbon Nanotechnology. Elsevier B.V, Ed. L. Dai; 2006. Р. 235-254.
  21. Martin N. Carbon nanoforms for photovoltaics: myth or reality? Adv Energy Mater. 2017;7:1601102. https://doi.org/10.1002/aenm.201601102.
  22. Project on Emerging Nanotechnologies. Dr. Daniel J. Fiorino. Charting a path. PEN19 – Voluntary Initiatives, Regulation, and Nanotechnology Oversigh. News. Available from: www.nanotechproject.org.
  23. The Wilson Center. Ground truth briefing a done deal? Addressing the U.S. Mexico Migration Challenge. Available from: www.wilsoncenter.org.
  24. Hadgraft J, Lane ME. Skin permeation: the years of enlightenment. Int J Pharm. 2005;305(1-2):2-12. https://doi.org/10.1016/j.ijpharm.2005.07.014.
  25. Raj S, Jose S, Sumod US, Sabitha M. Nanotechnology in cosmetics: Opportunities and challenges. J Pharm Bioallied Sci. 2012;4(3):186-193. https://doi.org/10.4103/0975-7406.99016.
  26. Crosera M, Bovenzi M, Maina G, et al. Nanoparticle dermal absorption and toxicity: a review of the literature. Int Arch Occup Environ Health. 2009;82(9):1043-1055. https://doi.org/10.1007/s00420-009-0458-x.
  27. Ahmad U, Ahmad Z, Khan AA, et al. Strategies in development and delivery of nanotechnology based cosmetic products. Drug Res (Stuttg). 2018;68(10):545-552. https://doi.org/10.1055/a-0582-9372.
  28. Hadgraft J, Somers G. Percutaneous absorption. J Pharm Pharmacol. 1956;8:625-634. https://doi.org/10.1111/j.2042-7158.1956.tb12194.x.
  29. Мизина П.Г., Быков В.А., Настина Ю.И., Фоменко Е.А. Введение лекарственных веществ через кожу — достижения и перспективы (обзор) // Вестник Воронежского государственного университета. – Серия «Химия. Биология. Фармация». – 2004. – № 1. – С. 176–183. [Mizina PG, Bykov VA, Nastina YuI, Fomenko EA. Transdermal drug delivery-achievements and developments (survey)achievements and developments (survey). Vestnik VGU. Series “Chemistry. Biology. Pharmacy”. 2004;(1):176-183. (In Russ.)]
  30. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov. 2004;3(2):115-124. https://doi.org/10.1038/nrd1304.
  31. Jafvert CT, Kulkarni PP. Buckminsterfullerene’s (C60) octanol-water partition coefficient (Kow) and aqueous solubility. Environ Sci Technol. 2008;42(16):5945-5950. https://doi.org/10.1021/es702809a.
  32. Крылова ЛА. Репаративные свойства фуллерена С60: Экспериментальное исследование: Автореф. дис. … канд. мед. наук. – СПб., 2003. – 22 с. [Krylova LA. Reparativnye svojstva fullerena S60: Eksperimental’noe issledovanie [dissertation]. Saint Petersburg; 2003. 22 р. (In Russ.)]. Доступно по: https://search.rsl.ru/ru/record/01002323558. Ссылка активна на 14.06.2018.
  33. Krusic PJ, Wasserman E, Keizer PN, et al. Radical reaction of C60. Science. 1991;254:1183-1185. https://doi.org/10.1126/science.254.5035.1183.
  34. McEwen CN, McKay RG, Larsen BS. C60 as a radical sponge. J Am Chem Soc. 1992;114(11):4412-4414. https://doi.org/10.1021/ja00037a064.
  35. Yin JJ, Lao F, Fu PP, et al. The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials. Biomaterials. 2009;30(4):611-621. https://doi.org/10.1016/j.biomaterials.2008.09.061.
  36. Fumelli C, Marconi A, Salvioli S, et al. Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis. J Invest Dermatol. 2000;115(5):835-841. https://doi.org/10.1046/j.1523-1747.2000.00140.x.
  37. Rondags A, Yuen WY, Jonkman MF, Horváth B. Fullerene C60 with cytoprotective and cytotoxic potential: prospects as a novel treatment agent in dermatology? Exp Dermatol. 2017;26(3):220-224. https://doi.org/10.1111/exd.13172.
  38. Hockberger PE. A history of ultraviolet photobiology for humans, animals and microorganisms. Photochem Photobiol. 2002;76(6):561-579. https://doi.org/10.1562/0031-8655(2002)0760561AHOUPF2.0.CO2.
  39. Clydesdale GJ, Dandie GW, Muller HK. Ultraviolet light induced injury: immunological and inflammatory effects. Immunol Cell Biol. 2001;79(6):547-568. https://doi.org/10.1046/j.1440-1711.2001.01047.x.
  40. Kammeyer A, Luiten RM. Oxidation events and skin aging. Ageing Res Rev. 2015;21:16-29. https://doi.org/10.1016/j.arr.2015.01.001.
  41. DʼOrazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Mol Sci. 2013;14:12222-12248. https://doi.org/10.3390/ijms140612222.
  42. Pandel R, Poljšak B, Godic A, Dahmane R. Skin photoaging and the role of antioxidants in its prevention. ISRN Dermatol. 2013;2013:930164. https://doi.org/10.1155/2013/930164.
  43. Poljsak B, Dahmane R, Godic A. Skin and antioxidants. J Cosmet Laser Ther. 2013;15:107-113. https://doi.org/10.3109/14764172.2012.758380.
  44. Chiang LY, Lai YL, Tsai MC, et al. Therapeutic use of watersoluble fullerene derivatives. Pat. USA US5994410, 1999.
  45. Chiang LY, Long Y. Fullerene derivatives as free-radical scavengers. Pat. USA US5648523, 1997.
  46. Kronholm DF, Hummelen JC, Sieval AB. Higher fullerenes useful as radical scavengers. Pat. USA US7825161, 2010.
  47. Kronholm DF, Sieval AB, Hummelen JC. Compounds and formulations suitable for radical scavenging. Pat. USA WO067436, 2008.
  48. Murakami M, Hyodo S, Fujikawa Y, et al. Photoprotective effects of inclusion complexes of fullerenes with polyvinylpyrrolidone. Photodermatol Photoimmunol Photomed. 2013;29(4):196-203. https://doi.org/10.1111/phpp.12050.
  49. Murthy CN, Choi SJ, Geckeler KE. Nanoencapsulation of [60]fullerene by a novel sugar-based polymer. J Nanosci Nanotechnol. 2002;2(2):129-132. https://doi.org/ 10.1166/jnn.2002.096.
  50. Lens MB, De Marni E, Gullo R, et al. Liposomes loaded with fullerene and process for their preparation. WO 2007043074. Apr 19, 2007.
  51. Yamakoshi YN, Yagami T, Fukuhara K, et al. Solubilization of fullerenes into water with polyvinylpyrrolidone applicable to biological tests. J Chem Soc Chem Commun. 1994. Р. 517-518. https://doi.org/10.1039/c39940000517.
  52. Williams RM, Crielaard W, Hellingwerf KJ, Verhoeven JW. Incorporation of fullerene-C60 and C60-adducts in micellar and vesicular supramolecular assemblies; Introductory flash photolysis and photoredox experiments in micelles. Rec Trav Chim Pays Bas. 1996;115:72-76. https://doi.org/10.1002/recl.19961150114.
  53. Takada H, Matsubayashi K. Process for producing PVP-fulleren complex and aqueous solution thereof. WO117877, 2006.
  54. Kato S, Aoshima H, Saitoh Y, Miwa N. Fullerene-C60 derivatives prevent UV-irradiation/ TiO2-induced cytotoxicity on keratinocytes and 3D-skin tissues through antioxidant actions. J Nanosci Nanotechnol. 2014;14(5):3285-3291. https://doi.org/10.1166/jnn.2014.8719.
  55. Saitoh Y, Ohta H, Hyodo S. Protective effects of polyvinylpyrrolidone-wrapped fullerene against intermittent ultraviolet-A irradiation-induced cell injury in HaCaT cells. J Photochem Photobiol B. 2016;163:22-29. https://doi.org/10.1016/j.jphotobiol.2016.08.001.
  56. Kato S, Aoshima H, Saitoh Y, Miwa N. Defensive effects of fullerene-C60 dissolved in squalane against the 2,4-nonadienal-induced cell injury in human skin keratinocytes HaCaT and wrinkle formation in 3D-human skin tissue model. J Biomed Nanotechnol. 2010;6(1):52-58. https://doi.org/10.1166/jbn.2010.1091.
  57. Xiao L, Takada H, Maeda K, et al. Antioxidant effects of water-soluble fullerene derivatives against ultraviolet ray or peroxylipid through their action of scavenging the reactive oxygen species in human skin keratinocytes. Biomed Pharmacother. 2005;59(7):351-358. https://doi.org/10.1016/j.biopha.2005.02.004.
  58. Xiao L, Takada H, Gan Xh, Miwa N. The water-soluble fullerene derivative “Radical Sponge” exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes. Bioorg Med Chem Lett. 2006;16(6):1590-1595. https://doi.org/10.1016/j.bmcl.2005.12.011.
  59. Xiao L, Matsubayashi K, Miwa N. Inhibitory effect of the water-soluble polymer-wrapped derivative of fullerene on UVA-induced melanogenesis via downregulation of tyrosinase expression in human melanocytes and skin tissues. Arch Dermatol Res. 2007;299(5-6):245-257. https://doi.org/10.1007/s00403-007-0740-2.
  60. Xiao L, Aoshima H, Saitoh Y, Miwa N. Fullerene-polyvinylpyrrolidone clathrate localizes in the cytoplasm to prevent Ultraviolet-A ray-induced DNA-fragmentation and activation of the transcriptional factor NF-kappaB. J Cell Biochem. 2010;111(4):955-966. https://doi.org/10.1002/jcb.22784.
  61. Kato S, Kikuchi R, Aoshima H, et al. Defensive effects of fullerene-C60/liposome complex against UVA-induced intracellular reactive oxygen species generation and cell death in human skin keratinocytes HaCaT, associated with intracellular uptake and extracellular excretion of fullerene-C60. J Photochem Photobiol B. 2010;98(2):144-151. https://doi.org/10.1016/j.jphotobiol.2009.11.015.
  62. Saitoh Y, Miyanishi A, Mizuno H, et al. Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages. J Photochem Photobiol B. 2011;102(1):69-76. https://doi.org/10.1016/j.jphotobiol.2010.09.006.
  63. Fumelli C, Marconi A, Salvioli S, et al. Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis. J Invest Dermatol. 2000;115(5):835-841. https://doi.org/10.1046/j.1523-1747.2000.00140.x.
  64. Takada H, Kokubo K, Matsubayashi K, Oshima T. Antioxidant activity of supramolecular water-soluble fullerenes evaluated by beta-carotene bleaching assay. Biosci Biotechnol Biochem. 2006;70(12):3088-3093. https://doi.org/10.1271/bbb.60491.
  65. Ito S, Itoga K, Yamato M, et al. The co-application effects of fullerene and ascorbic acid on UV-B irradiated mouse skin. Toxicology. 2010;267(1-3):27-38. https://doi.org/10.1016/j.tox.2009.09.015.
  66. Sajo ME, Kim CS, Kim SK, et al. Antioxidant and anti-inflammatory effects of shungite against Ultraviolet B irradiation-induced skin damage in hairless mice. Oxid Med Cell Longev. 2017;2017:7340143. https://doi.org/10.1155/2017/7340143.
  67. Toyoda M, Morohashi M. Pathogenesis of acne. Med Electron Microsc. 2001;34(1):29-40. https://doi.org/10.1007/s0079510340029.
  68. Bowe WP, Logan AC. Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles. Lipids Health Dis. 2010;9:141. https://doi.org/10.1186/1476-511X-9-141.
  69. Bowe WP, Patel N, Logan AC. Acne vulgaris: the role of oxidative stress and the potential therapeutic value of local and systemic antioxidants. J Drugs Dermatol. 2012;11(6):742-746.
  70. Garg T. Current nanotechnological approaches for an effective delivery of bio-active drug molecules in the treatment of acne. Artif Cells Nanomed Biotechnol. 2016;44(1):98-105. https://doi.org/10.3109/21691401.2014.916715.
  71. Inui S, Aoshima H, Ito M, et al. Inhibition of sebum production and Propionibacterium acnes lipase activity by fullerenol, a novel polyhydroxylated fullerene: potential as a therapeutic reagent for acne. J Cosmet Sci. 2012;63(4):259-265.
  72. Aoshima H, Kokubo K, Shirakawa S, et al. Antimicrobial activity of fullerenes and their hydroxylated derivatives. Biocontrol Sci. 2009;14(2):69-72. https://doi.org/10.4265/bio.14.69.
  73. Inui S, Aoshima H, Nishiyama A, Itami S. Improvement of acne vulgaris by topical fullerene application: unique impact on skin care. Nanomedicine. 2011;7(2):238-241. https://doi.org/10.1016/j.nano.2010.09.005.
  74. Size of the global hair care market from 2012 to 2021 (in billion U.S. dollars) [cited 02/01/2016]. Available from: http://www.statista.com/statistics/254608/global-hair-care-market-size/.
  75. Handbook of cosmetic science and technology informa health care. Ed. by A.O. Barel, M.P. Howard, I. Maibach. Informa Healthcare USA, Inc.; 2009.
  76. Hunt N, McHale S. The psychological impact of alopecia. BMJ. 2005;331(7522):951-953. https://doi.org/10.1136/bmj.331.7522.951.
  77. Ramos PM, Miot HA. Female pattern hair loss: a clinical and pathophysiological review. An Bras Dermatol. 2015;90(4):529-543. https://doi.org/10.1590/abd1806-4841.20153370.
  78. França K, Rodrigues TS, Ledon J, et al. Comprehensive overview and treatment update on hair loss. J Cosmet Dermatol Sci Appl. 2013;3:1-8.
  79. Ramos PM., Miot HA. Female pattern hair loss: a clinical and pathophysiological review. An Bras Dermatol. 2015;90:529-543. https://doi.org/10.1590/abd1806-4841.20153370.
  80. Shrivastava SB. Diffuse hair loss in an adult female: approach to diagnosis and management. Indian J Dermatol Venereol Leprol. 2009;75(1):20-27; quiz 27-28. https://doi.org/10.4103/0378-6323.45215.
  81. Gupta AK, Charrette A. Topical minoxidil: systematic review and meta-analysis of its efficacy in androgenetic alopecia. Skinmed. 2015;13(3):185-189.
  82. Farhangian ME, McMichael AJ, Huang KE, Feldman SR. Treatment of alopecia areata in the united states: a retrospective cross-sectional study. J Drugs Dermatol. 2015;14(9):1012-1014.
  83. Zhou Z, Lenk R, Dellinger A, et al. Fullerene nanomaterials potentiate hair growth. Nanomedicine. 2009;5(2):202-207. https://doi.org/10.1016/j.nano.2008.09.005.
  84. Trüeb RM. Oxidative stress in ageing of hair. Int J Trichology. 2009;1(1):6-14. https://doi.org/10.4103/0974-7753.51923.
  85. Akar A, Arca E, Erbil H, et al. Antioxidant enzymes and lipid peroxidation in the scalp of patients with alopecia areata. J Dermatol Sci. 2002;29(2):85-90. https://doi.org/10.1016/S0923-1811(02)00015-4.
  86. Inui S, Mori A, Ito M, et al. Reduction of conspicuous facial pores by topical fullerene: possible role in the suppression of PGE2 production in the skin. J Nanobiotechnology. 2014;12:6. https://doi.org/10.1186/1477-3155-12-6.
  87. Fujimoto T, Ito S, Ito M, et al. Induction of different reactive oxygen species in the skin during various laser therapies and their inhibition by fullerene. Lasers Surg Med. 2012;44(8): 685-694. https://doi.org/10.1002/lsm.22065.88.
  88. https: www.cir-s.
  89. https: www.ewg.
  90. Технический регламент Таможенного союза «О безопасности парфюмерно-косметической продукции» (утв. Решением Комиссии Таможенного союза от 23 сентября 2011 г. № 799). [Tekhnicheskij reglament tamozhennogo soyuza “O bezopasnosti parfyumerno-kosmeticheskoi produktsii” (utv. Resheniem Komissii Tamozhennogo soyuza ot 23 sentyabrya 2011 g. No. 799). (In Russ.)]. Доступно по: www.eurasiancommission.org/ru/Lists/EECDocs/P_799_3.pdf. Ссылка активна на 14.04.2019.
  91. Gharbi N, Pressac M, Hadchouel M, et al. [60] Fullerene is an in vivo powerful antioxidant with no acute or sub-acute toxicity. Nano Letters. 2005;5(12):2578-2585. https://doi.org/10.1021/nl051866b.
  92. Kato S, Aoshima H, Saitoh Y, Miwa N. Biological safety of LipoFullerene composed of squalane and fullerene-C60 upon mutagenesis, photocytotoxicity, and permeability into the human skin tissue. Basic Clin Pharmacol Toxicol. 2009;104(6):483-487. https://doi.org/10.1111/j.1742-7843.2009.00396.x.
  93. Kato S, Taira H, Aoshima H, et al. Clinical evaluation of fullerene-C60 dissolved in squalane for anti-wrinkle cosmetics. J Nanosci Nanotechnol. 2010;10(10):6769-6774. https://doi.org/10.1166/jnn.2010.3053.
  94. Aoshima H, Saitoh Y, Ito S, et al. Safety evaluation of highly purified fullerenes (HPFs): based on screening of eye and skin damage. J Toxicol Sci. 2009;34(5):555-562. https://doi.org/10.2131/jts.34.555.
  95. Xia XR, Monteiro-Riviere NA, Riviere JE. Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents. Toxicol Appl Pharmacol. 2010;242(1):29-37. https://doi.org/10.1016/j.taap.2009.09.011.
  96. Souto GD, Pohlmann AR, Guterres SS. Ultraviolet A irradiation increases the permeation of fullerenes into human and porcine skin from C60-poly(vinylpyrrolidone) aggregate dispersions. Skin Pharmacol Physiol. 2015;28(1):22-30. https://doi.org/10.1159/000362175.
  97. Dumpis MА, Iljin VV, Litasova EV, et al. The acute and sub-acute toxicity of С60/PVP complex in vivo. Advances in Nano Research. 2016;4(3):167-179. https://doi.org/10.12989/anr.2016.4.3.167.
  98. Aschberger K, Johnston HJ, Stone V, et al. Review of fullerene toxicity and exposure — appraisal of a human health risk assessment, based on open literature. Regul Toxicol Pharmacol. 2010;58(3):455-473. https://doi.org/10.1016/j.yrtph.2010.08.017.
  99. Oberdörster E. Manufactured nanomaterials (fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ Health Perspect. 2004;112(10):1058-1062. https://doi.org/10.1289/ehp.7021.
  100. Halford B. Fullerene for the face. Chem Eng News. 2006;84:47.
  101. Fullerenes C60 and Dr Brandt Lineless Cream [cited 2008 February 27]. Available from: https://www.truthinaging.com/review/fullerenes-C60-and-dr-brandt-lineless-cream.
  102. Fortner ID, Lyon DY, Sayes CM, et al. C60 in water: nanocrystal formation and microbial response. Environ Sci Technol. 2005;39:4307-4316. https://doi.org/10.1021/es048099n.
  103. Henry TB, Menn FM, Fleming JT, et al. Attributing effects of aqueous C60 nano-aggregates to tetrahydrofuran decomposition products in larval zebrafish by assessment of gene expression. Environ Health Perspect. 2007;115(7):1059-65. https://doi.org/10.1289/ehp.9757.
  104. Oberdorster E, Zhu S, Blickley TM, et al. Ecotoxicology of carbon-based engineered nanoparticles: Effects of fullerene (C60) on aquatic organisms. Carbon. 2006;44:1112-20. https://doi.org/10.1016/j.carbon.2005.11.008.
  105. Википедия [интернет]. Доступно по: https://ru.wikipedia.org/wiki/Космецевтика. Ссылка активна на 15.02.2019.
  106. U.S. Food and Drug Administration. Is it a cosmetic, a drug, or both? (Or is it soap?). U.S. Department of Health and Human Services; April 30, 2012.
  107. Wayback Machine. Internet Archiveʼs. Available from: https://web.archive.org/web/20061230154631/.
  108. Dellinger AL, Cunin P, Lee D, et al. Inhibition of inflammatory arthritis using fullerene nanomaterials. PLoS One. 2015;10(4): e0126290. https://doi.org/10.1371/journal.pone.0126290.
  109. Shershakova N, Baraboshkina E, Andreev S, et al. Anti-inflammatory effect of fullerene C60 in a mice model of atopic dermatitis. J Nanobiotechnol. 2016;14:8. https://doi.org/10.1186/s12951-016-0159-z.
  110. Ema M, Matsuda A, Kobayashi N, et al. Dermal and ocular irritation and skin sensitization studies of fullerene C60 nanoparticles. Cutan Ocul Toxicol. 2013;32(2):128-134. https://doi.org/10.3109/15569527.2012.727937.
  111. Lens M. Recent progresses in application of fullerenes in cosmetics. Recent Pat Biotechnol. 2011;5(2):67-73. https://doi.org/10.2174/187220811796365707.
  112. Lens M. Use of fullerenes in cosmetics. Recent Pat Biotechnol. 2009;3(2):118-123. https://doi.org/10.2174/ 187220809788700166.
  113. Vitamin C60 BioResearch Corporation. Our fullerene-containing cosmetic ingredient. VC60 All Rights Reserved; 2016. Available from: http: www.vc60.com/en/product/.
  114. http: www.vc60.com/en/product/Vitamin C60 Bioresearch Corporation. Product information.
  115. http: jp1023114521
  116. Сезон красоты. Бутик косметики, салон красоты и парикмахерская. Доступно по: https://seasonkrasoty.ru. Ссылка активна на 15.02.2019.
  117. Melon_Panda. Фуллерен — революция антистарения [обновление от 17 февраля 2016]. Доступно по: https://melon-panda.livejournal.com/585693.html.
  118. Litasova EV, Iljin VV, Sokolov A, et al. The biodegradation of fullerene C60 by myeloperoxidase. Dokl Biochem Biophys. 2016;471(1):417-420. https://doi.org/10.1134/S1607672916060119.
  119. Думпис М.А., Николаев Д.Н., Литасова Е.В., и др. Биологическая активность фуллеренов — реалии и перспективы // Обзоры клинической фармакологии и лекарственной терапии. – 2018. – Т. 16. – № 1. – С. 4–20. [Dumpis MA, Nikolaev LN, Litasova EV, et al Biological activity of fullerenes – reality and perspectives. Reviews on Clinical Pharmacology and Drug Therapy. 2018;16(1):4-20. (In Russ.)]. https://doi.org/10.17816/RCF1614-20.

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