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Post a Comment Some pharmacokinetics aspects of new analgetics from hexaazaisiowuritsitane class in rats
- Authors: Lopatina K.A.1, Bryushinina O.S.1, Gurto R.V.1, Krylova S.G.1, Zuzkova Y.G.1, Kulagina D.A.2, Safonova E.A.1, Zueva E.P.1, Sysolyatin S.V.2
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Affiliations:
- Tomsk National Research Medical Center of the RAS, Goldberg Research Institute of Pharmacology and Regenerative Medicine
- Institute for Problems of Chemical and Energetic Technologies of the Siberian Branch оf the RAS
- Issue: Vol 17, No 4 (2019)
- Pages: 51-56
- Section: Original study articles
- URL: https://journals.rcsi.science/RCF/article/view/13498
- DOI: https://doi.org/10.17816/RCF17451-56
- ID: 13498
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Abstract
An important stage in the preclinical study of a new drug is the study of its pharmacokinetics: absorption, distribution, metabolism, and excretion of the drug compound.
The purpose of this study was to study the pharmacokinetics in healthy animals of a new analgesic based on hexaazaisowurtzitane (thiowurtzine).
Materials and methods. A technique for determining the concentration of thiowurtzine in the blood plasma and rat excreta has been developed and validated. Using high-performance liquid chromatography and tandem mass spectrometry, concentrations of thiowurtzine in plasma and rat excreta were determined after a single intragastric dose of 100 mg/kg.
Results. The peak concentration of thiowurtzine in the blood plasma of rats accounts for 2 hours, which is consistent with the pharmacodynamic data of the analgesic, the average retention time of the substance in the body reached 17.15 h after administration. Thiowurtzine is believed to be actively metabolized.
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##article.viewOnOriginalSite##About the authors
Ksenya A. Lopatina
Tomsk National Research Medical Center of the RAS, Goldberg Research Institute of Pharmacology and Regenerative Medicine
Author for correspondence.
Email: k.lopatina@pharmso.ru
PhD, Senior Researcher of Oncopharmacology Laboratory
Russian Federation, TomskOlga S. Bryushinina
Tomsk National Research Medical Center of the RAS, Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: k.lopatina@pharmso.ru
PhD, Researcher of Molecular and Clinical Physiology Laboratory
Russian Federation, TomskRoman V. Gurto
Tomsk National Research Medical Center of the RAS, Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: roman.gurto@pharmso.ru
PhD, Leading Researcher of Molecular and Clinical Physiology Laboratory
Russian Federation, TomskSvetlana G. Krylova
Tomsk National Research Medical Center of the RAS, Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: krylova5935@gmail.com
PhD, MD, Leading Researcher of Oncopharmacology Laboratory
Russian Federation, TomskYulia G. Zuzkova
Tomsk National Research Medical Center of the RAS, Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: roman.gurto@pharmso.ru
Junior Researcher of Molecular and Clinical Physiology Laboratory
Russian Federation, TomskDarya A. Kulagina
Institute for Problems of Chemical and Energetic Technologies of the Siberian Branch оf the RAS
Email: imbiri@rambler.ru
PhD, Researcher of Medical Chemistry Laboratory
Russian Federation, BiyskElena A. Safonova
Tomsk National Research Medical Center of the RAS, Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: safonova_7@mail.ru
PhD, Researcher of Oncopharmacology Laboratory
Russian Federation, TomskElena P. Zueva
Tomsk National Research Medical Center of the RAS, Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zep0929@mail.ru
PhD, MD, Head of Oncopharmacology Laboratory
Saint Helena, Ascension and Tristan da Cunha, TomskSergey V. Sysolyatin
Institute for Problems of Chemical and Energetic Technologies of the Siberian Branch оf the RAS
Email: imbiri@rambler.ru
PhD, MD, Head. Institute for Problems of Chemical and Energetic Technologies of the Siberian Branch оf the RAS
Russian Federation, BiyskReferences
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