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Post a Comment Assessment of drugs belonging to inhibitors and inductors of p-glycoprotein in vitro
- Authors: Yakusheva E.N.1, Shchulkin A.V.1, Chernykh I.V.1, Popova N.M.1, Kotlyarova A.A.1, Slepnev A.A.1
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Affiliations:
- Ryazan State Medical University
- Issue: Vol 17, No 1 (2019)
- Pages: 71-78
- Section: Original study articles
- URL: https://journals.rcsi.science/RCF/article/view/12969
- DOI: https://doi.org/10.17816/RCF17171-78
- ID: 12969
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Abstract
The article describes modern approaches for testing of drugs belonging to substrates and inhibitors of P-glycoprotein (Pgp, ABCB1-protein, MDR1-protein) according to the recommendations of Food and Drug Administration (United States) and European Medicines Agency. In vitro methods on cell lines with hyperexpression of the transporter are presented. The same analysis was done on human colon adenocarcinoma cell line (Caco-2).
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##article.viewOnOriginalSite##About the authors
Elena N. Yakusheva
Ryazan State Medical University
Author for correspondence.
Email: e.yakusheva@rzgmu.ru
MD, PhD, Professor, Head of Pharmacology Department with Course of Pharmacy of Continuing Professional Education Faculty
Russian Federation, RyazanAleksey V. Shchulkin
Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
MD, PhD, Assistant Professor of Pharmacology Department with Course of Pharmacy of Continuing Professional Education Faculty
Russian Federation, RyazanIvan V. Chernykh
Ryazan State Medical University
Email: ivchernykh88@mail.ru
PhD in Biological sciences, Assistant of the Department of General Chemistry and Pharmachemistry
Russian Federation, RyazanNatalia M. Popova
Ryazan State Medical University
Email: p34-66@yandex.ru
MD, PhD, Senior Teacher of Pharmacology Department with Course of Pharmacy of Continuing Professional Education Faculty
Russian Federation, RyazanAnna A. Kotlyarova
Ryazan State Medical University
Email: kaa.rz@yandex.ru
Assistant of Pharmacology Department with Course of Pharmacy of Continuing Professional Education Faculty
Russian Federation, RyazanAlexandr A. Slepnev
Ryazan State Medical University
Email: a.slepnev@rzgmu.ru
PhD in Biological sciences, Assistant Professor of Pharmacology Department with Course of Pharmacy of Continuing Professional Education Faculty
Russian Federation, RyazanReferences
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