Biodizine as a civilizational challenge of modern pharmaceuticals

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Abstract

The review discusses the role of pharmaceutical and drug design methodology in the development of the high-tech segment of the development and production of original drugs for personalized and precision medicine (PPM). Topical issues of using predictively personalized tools for precision medicine in pharmaceuticals are highlighted. New opportunities and prospects for increasing the effectiveness of drugs in various fields of medicine created on the basis of pharmaceutical design are shown. Discussed are original approaches to standardization and reproducibility of the effects of new drugs at the preclinical stage using microfluidic bioconstructs – organ-on-a-chip systems. The relevance of improving university curricula for training specialists in the field of molecular drug design (drug design), harmonized with dynamically developing biotechnologies in pharmaceuticals, as well as the needs of domestic healthcare in original medicines for PPM, is shown.

About the authors

Alexander I. Tyukavin

Saint Petersburg State Chemical and Pharmaceutical University

Email: alexander.tukavin@pharminnotech.com
SPIN-code: 8476-5366

Doctor of Medicine (MD), Professor, Head of the Department to Physiology and Pathology

Russian Federation, Saint Petersburg

Nikolay А. Arseniev

Saint Petersburg State Chemical and Pharmaceutical University

Email: nikolay.arseniev@pharminnotech.com
SPIN-code: 9038-7623

Ph.D in Biology, Associate Professor of the Department to Physiology and Pathology

Russian Federation, Saint Petersburg

Maria A. Studneva

Moscow State University of Food Production; European Association for Predictive, Preventive and Personalized Medicine, EU

Email: maria.studneva@gmail.com

Assistant of the Department to Personalized Medicine, Precision Nutrition and Biodesign

Russian Federation, Moscow; Brussels

Veronika S. Medvedeva

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: med_nika2000@mail.ru

Student

Russian Federation, Moscow

Sergey V. Suchkov

Moscow State University of Food Production; A. I. Yevdokimov Moscow State University of Medicine and Dentistry; European Association for Predictive, Preventive and Personalized Medicine, EU

Author for correspondence.
Email: ssuchkov57@gmail.com
SPIN-code: 7052-7335

Doctor of Medicine (MD), Professor, Head of the Department to Personalized Medicine, Professor of the Department of Clinical Allergology and Immunology

Russian Federation, Moscow; Moscow; Brussels

References

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Supplementary files

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2. Fig. 1. Various concepts at the intersection of sciences

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3. Fig. 2. The share of original drugs in the total number of drugs registered in the Russian Federation in the period from 2010 to 2019 [3]

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4. Fig. 3. The number of drugs with a new active ingredient, registered in the Russian Federation, developed by domestic researchers [3]

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5. Fig. 4. Normal physiological insulin secretion

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6. Fig. 5. Insulin pump (electronic syringe). On the left is a diagram of the insulin injector device. On the right is the location of the device on the human body. 1 – pump with reservoir; 2 – infusion system; 3 – cannula / catheter [6]

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7. Fig. 6. Dynamics of the average annual growth rates of design translational developments in the bioindustry

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8. Fig. 7. Scheme of the effect of the targeted effect of eToeholds. 5 – viral protein of the pathogen [7]

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9. Fig. 8. «Backpacks» of nanoparticles (pink - left; purple - right) attached to the macrophage cell release a steady stream of cytokines to keep the cell activated against cancerous tumors. Source: Wyss Institute at Harvard University

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10. Fig. 9. System for obtaining nanosized vesicles for transportation of biological products in the human body with parenteral and minimally invasive methods of administration. Source: Wyss Institute and John A. Paulson Harvard School of Engineering and Applied Sciences

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11. Fig. 10. Microfluidic drug testing devices

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12. Fig. 11. The Man-on-Chip Model

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13. Fig. 12. Modeling of cystic fibrosis. Left - light-on-a-chip system; on the right is a cystic fibrosis-on-a-chip model. Source: Wyss Institute at Harvard University

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14. Fig. 13. Diagram of the intestine-on-a-chip construction. Source: Wyss Institute at Harvard University

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15. Fig. 14. Micro device for monitoring hemostasis. Source: Wyss Institute at Harvard University

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Copyright (c) 2021 Tyukavin A.I., Arseniev N.А., Studneva M.A., Medvedeva V.S., Suchkov S.V.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


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