State of the Russian Oncology Service: lip cancer. Population-based study at the federal district level. Part I. Incidence rate, annual mortality rate, localization and histological structure

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Abstract

Malignant neoplasms of the lip (C00) are rare types of malignancies. It is ranked 30 in terms of the structure of oncopathology in Russia and the Northwestern Federal District of the Russian Federation. There is a positive trend in the incidence rate as its share takes modestly 0,4% (both sexes) in the database of the Population-based Cancer Registry (PCR) of the Northwestern Federal Region of the Russian Federation.

It should be noted that according to the official reporting (Form No. 7) it is impossible to obtain any other criteria for assessing the effectiveness of combating this tumor in addition to the trends of morbidity. We have presented the estimation on the state of the effectiveness of anticancer measures regarding malignant tumors of the lip (C00) on the basis of the PCR database of Saint Petersburg.

In February 2019 we created a unified database of malignant neoplasms of the Federal Region. In fact, there has been organized the first in Russia Population-based Cancer Registry at the Federal Region level. As of January 1, 2020 the Northwestern Federal Region of the Russian Federation (NWFD RF) includes 11 subjects with the population of 1 397 727. Total number of registered lip cancer cases – more than 1 million 350 thousand cases. To develop analytical criteria, only reliable materials –952791 cases including 2663 cases of malignant tumors of the lip were selected.

Aim and objectives of the study were to determine the prevalence of malignant neoplasms of the lip, annual mortality, features of localization and histological structure.

Materials for the study were cancer incidence books. Standard research methods recommended by the International Association of Cancer Registries were used.

The study has revealed a high level of lip cancer morbidity of the population in Russia and the North-Western Federal District against the background of indicators for economically developed countries, but the incidence rate is gradually decreasing.

The highest standardized incidence rate of malignant tumors of the lip in the Northwestern Federal District of the Russian Federation remains among the male population of the Vologda, Pskov regions and the Komi Republic.

We have established a special procedure for the death of patients with malignant neoplasms of the lip in the Northwestern Federal District of the Russian Federation. A surge in mortality from lip cancer has been revealed in women in the second, fourth, seventh, ninth and tenth years of follow-up, in men – in the fourth, seventh and tenth. It requires fundamental research to identify the causes of the surge in mortality. Unfavorable annual mortality trends have been revealed. The features of localization and histological structure of malignant tumors of the lip have been established.

About the authors

Vakhtang M. Merabishvili

N.N. Petrov National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation; Saint Petersburg Regional Charitable Foundation “Cancer Prevention”

Author for correspondence.
Email: MVM@niioncologii.ru
ORCID iD: 0000-0002-1521-455X
SPIN-code: 5705-6327

Doctor of Medicine (MD), Professor, Chief of the Oncological Statistics Scientific Laboratory, Chairman of the Scientific-Methodological Council on the Development of Information Systems of Cancer Control of the Northwestern Federal District; Head of the Population-based Cancer Registry of the Northwestern Federal District of the Russian Federation

Russian Federation, Saint Petersburg; Saint Petersburg

Alexander B. Vasilyev

Saint Petersburg Regional Charitable Foundation “Cancer Prevention”

Email: 5849898@bk.ru

Chief Medical Officer

Russian Federation, Saint Petersburg

Elvira N. Merabishvili

North-Western State Medical University named after I.I. Mechnikov of the Healthcare Ministry of the Russian Federation

Email: MVM@niioncologii.ru

Ph.D. in Medicine, Senior Lecturer, Department of Human Morphology

Russian Federation, Saint Petersburg

Alexey F. Barsukov

North-Western State Medical University named after I.I. Mechnikov of the Healthcare Ministry of the Russian Federation

Email: MVM@niioncologii.ru

Ph.D. in Medicine, Doctor of the highest qualification category, Department of Otorhinolaryngology (ENT), Clinic named after Peter the Great

Russian Federation, Saint Petersburg

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Supplementary files

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2. Fig. 1. Malignant neoplasms in some countries. Lip (C00). Males. 2008–2012. Cancer incidence in Five Continents. XI IARC [1, 4, 5]

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3. Fig. 2. Malignant neoplasms in some countries. Lip (C00). Females. 2008–2012. Cancer incidence in Five Continents. XI IARC [1, 4, 5]

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4. Fig. 3. Age-specific lip cancer incidence rate. Males [3–5]

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5. Fig. 4. Age-specific lip cancer incidence rate. Females [3–5]

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6. Fig. 5. Trends in lip cancer incidence in Russia and the Northwestern Federal District of the Russian Federation (NWFD RF). Males

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7. Fig. 6. Trends in lip cancer incidence in Russia and the NWFD RF. Females

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8. Fig. 7. Annual lip cancer mortality rate in the NWFD RF. 2000–2004. NWFD RF Population-based Cancer Registry (PCR) database

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9. Fig. 8. Annual lip cancer mortality rate in the NWFD RF. 2005–2009. NWFD RF PCR database

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10. Fig. 9. Annual lip cancer mortality rate in the NWFD RF. 2010–2014. NWFD RF PCR database

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Copyright (c) 2021 Merabishvili V.M., Vasilyev A.B., Merabishvili E.N., Barsukov A.F.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


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