Development of the design of the preclinical trials of radiopharmaceuticals for the radionuclide diagnostics and therapy based on the AMBA peptide
- Authors: Stanzhevsky A.A.1, Mosunov A.A.2, Chipiga L.A.1,3,4, Vodovatov A.V.3,5, Naurzbaeva L.6, Kushnarenko S.M.6, Lavreshov D.D.6, Petrova A.E.6
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Affiliations:
- A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies
- Peter the Great St.Petersburg Polytechnic University
- Saint Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev
- Almazov National Medical Research Centre
- Saint Petersburg State Pediatric Medical University
- Peter the Great Saint Petersburg Polytechnic University
- Issue: Vol 2, No 4 (2020)
- Pages: 60-71
- Section: Biomedical Sciences
- URL: https://journals.rcsi.science/PharmForm/article/view/52958
- DOI: https://doi.org/10.17816/phf52958
- ID: 52958
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Abstract
The present study is related to one of the promising areas of nuclear medicine: the use of peptides – bombesin analogues, labeled with 68Ga – for diagnosis and 177Lu – for therapy of prostate cancer. In the Russian Federation, preclinical trials of similar radiopharmaceutical drugs are in the study design stage. The aim of the current study was to develop the design of the preclinical study for the radiopharmaceutical drugs to assess the biodistribution of a peptide, an analogue of bombesin, intended for the diagnosis and treatment of prostate cancer.
The study was based on the meta-analysis of the available publications in peer-reviewed journals. The analysis was performed using the full-text archive of biomedical and life sciences journals PubMed Central for the following keywords: “radionuclide therapy”, “nuclear medicine”, “AMBA”, “68Ga” и “177Lu”. The study included the comparative analysis of the animal and patient samples, methods of data collection and results of the accumulation of radiopharmaceuticals in nodules and radiosensitive organs and tissues.
The results of the study allowed proposing the minimal requirements for the animal samples (at least 30 animals for each radiopharmaceutical), data collection (direct radiometry and PET) and time points (not less than 5 measurements in 120-240 minutes for the radiopharmaceuticals labeled with 68Ga and 5 measurements in 336 hours for the radiopharmaceuticals labeled with 177Lu) for the assessment of the biodistribution of the radiopharmaceuticals.
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##article.viewOnOriginalSite##About the authors
Andrey A. Stanzhevsky
A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies
Email: stanzhevsky@gmail.com
Doctor of Medicine (MD), Deputy Director for research
Russian Federation, 197758, Saint Petersburg, Pesochny settlement, Leningradskaya str., 70Artem A. Mosunov
Peter the Great St.Petersburg Polytechnic University
Email: zawq2000@gmail.com
student
Russian Federation, 195251, Saint Petersburg, Politechnicheskaya str., 29Larisa A. Chipiga
A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies; Saint Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev; Almazov National Medical Research Centre
Author for correspondence.
Email: Larisa.chipiga@gmail.com
Ph.D. in Engineering Sciences, Researcher at the laboratory of radiation hygiene of medical organizations, Researcher, docent
Russian Federation, 197758, Saint Petersburg, Pesochny settlement, Leningradskaya str., 70; 8 Mira street, Saint Petersburg, 197101; 197341, Saint Petersburg, akkuratova str., 2Aleksandr V. Vodovatov
Saint Petersburg Research Institute of Radiation Hygiene after Professor P.V. Ramzaev; Saint Petersburg State Pediatric Medical University
Email: vodovatoff@gmail.com
Ph.D. in Biological Sciences, Head of radiation hygiene of medical organizations, Associate Professor, Department of Hygiene
Russian Federation, 8 Mira street, Saint Petersburg, 197101, Russia; 194100, Saint Petersburg, Litovskaya str., 2Laura Naurzbaeva
Peter the Great Saint Petersburg Polytechnic University
Email: naurzbaeva.laura@gmail.com
student
Russian Federation, 195251, Saint Petersburg, Politechnicheskaya str., 29Stanislav M. Kushnarenko
Peter the Great Saint Petersburg Polytechnic University
Email: arichikaaris@mail.ru
student
Russian Federation, 195251, Saint Petersburg, Politechnicheskaya str., 29Dmitry D. Lavreshov
Peter the Great Saint Petersburg Polytechnic University
Email: ldd99@mail.ru
student
Russian Federation, 195251, Saint Petersburg, Politechnicheskaya str., 29Anna E. Petrova
Peter the Great Saint Petersburg Polytechnic University
Email: anyapetrova2797@gmail.com
student
Russian Federation, 195251, Saint Petersburg, Politechnicheskaya str., 29References
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