Identification of actoprotective compounds among Krebs cycle acid/aminoethanol derivatives

This study was carried out taking into account the fact that the search for and introduction into medical practice of drugs for the pharmacological correction of fatigue and restoration of physical performance in asthenic phenomena after illness, physical exertion in military personnel, athletes and the elderly continues to remain relevant.
In the course of the study, we aimed to study the effect of dimethylamino and diethylaminoethanol derivatives with
tricarboxylic acid cycle intermediates (aminoethanol derivatives with Krebs cycle acids) on the physical performance of white outbred male mice.
The study was carried out on 490 outbred male mice with body weight 22-24 grams. The limit swimming test with a load was chosen as a screening model to study the effect of new compounds on physical performance.
To select the most effective of the synthesized compounds, a screening of the pharmacological activity of the effect of the new compounds, fumar ester of diethylamino and dimethylaminoethanol with Krebs cycle intermediates, on the physical performance of male mice was performed.
Statistical processing of the data obtained to establish differences between groups was performed using the F-test of ANOVA.
Studies have shown that in their effect on physical performance, these compounds were superior to the reference drug - deanol aceglumate at an optimal dose of 50 mg / kg.
In the process of developing new actoprotective agents, we consider it appropriate to use the ability of the Krebs cycle acids to enhance the antihypoxic, actoprotective and nootropic activity of the base cationic groups in salts.