Email this article THE INTERACTION OF CHANGES IN PULMONARY HEMODYNAMICS AND VENOUS RETURN FOLLOWING PULMONARY THROMBOEMBOLISM
- Authors: Evlakhov VI1, Poyassov IZ1, Shaidakov EV1
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Affiliations:
- Institute of Experimental Medicine
- Issue: Vol 16, No 1 (2016)
- Pages: 44-49
- Section: Articles
- URL: https://journals.rcsi.science/MAJ/article/view/9479
- DOI: https://doi.org/10.17816/MAJ16144-49
- ID: 9479
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Abstract
Acute experiments with rabbits were used to study changes in pulmonary haemodynamics in a model of pulmonary artery thromboembolism under intact circulatory conditions and upon volumetric clamp perfusion of the lungs. Under intact circulatory conditions, blood pressure in the pulmonary artery increased upon thrompoembolism to a lesser degree than under perfusion of the lungs, because pulmonary blood flow decreased. In both cases, pulmonary vascular resistance increased equally. Upon caudal vena cava stenosis, blood pressure and flow decreased in the pulmonary artery, the later decrement being the same as in the case of thromboembolism. At the same time, upon caudal vena cava stenosis, pulmonary vascular resistance increased two time less than in response to pulmonary artery thromboembolism. Under pulmonary artery thromboembolism, blood pressure in the artery depended on changes in pulmonary blood flow and pulmonary vascular resistance. Changes in blood flow through the pulmonary artery were caused by changes in venous return and myocardial contractility and did not correlate with pulmonary vascular resistance.
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##article.viewOnOriginalSite##About the authors
V I Evlakhov
Institute of Experimental Medicine
Email: viespbru@mail.ru
I Z Poyassov
Institute of Experimental Medicine
Email: ilpoar@yandex.ru
E V Shaidakov
Institute of Experimental Medicine
Email: evgenyshaydakov@gmail.com
References
- Флебология: руководство для врачей / под ред. В. С. Савельева.- М.: Медицина,2001.- 664 с.
- Goldhaber S. Z., Elliott C. G. Acute pulmonary embolism: part I. Epidemiology, pathophysiology and diagnosis //Circulation.- 2003.- Vol. 108.- P. 2726-2729.
- Naeije R., Manes A. The right ventricle in pulmonary arterial hypertension // Eur. Respir. Rev.- 2014.- Vol. 134.- P. 476-487.
- Ventetuolo C. E., Klinger J. R. Management of acute right ventricular failure in the intensive care unit // Ann. Am. Thorac. Soc.- 2014.- Vol. 11.- P. 811-822.
- Watts J. A., Marchick M. R., Kline J. A. Right ventricular heart failure from pulmonary embolism: key distinctions from chronic pulmonary hypertension // J. Card. Fail.- 2010.- Vol. 16.- P. 250-259.
- Otero R., Oribe M., Ballaz A., Jimenez D., Uresandi F., Nauffal D., Conget F., Rodriguez C., Elias T., Jara L., Cayuela A., Blanco I., Barbera J. Echocardiographic assessment of pulmonary arterial pressure in the follow-up of patients with pulmonary embolism // Thromb. Res.- 2011.- Vol. 127.- P. 303-308.
- Naeije R. Physiology of the pulmonary circulation and the right heart // Curr. Hypertens. Rep.- 2013.- Vol. 15.- P. 623-631.
- Ткаченко Б. И., Евлахов В. И., Поясов И. З. Гемодинамические механизмы изменений давления и кровотоков легочной артерии при применении прессорных веществ // Рос. физиол. журн. им. И. М. Сеченова.- 2008.- T. 94, № 8.- С. 888-899.
- Ткаченко Б. И., Евлахов В. И., Поясов И. З. Соотношения изменений параметров легочной и системной гемодинамики при нейрогенных стимулах // Рос. физиол. журн. им. И. М. Сеченова.- 2008.- T. 94, № 4.- С. 421-431.
- Chen H. M., Duan Y. Y., Li J., Zhou N., Yuan L. J., Cao T. S., Hou W., Zhang H. X., Cao W., Yang Y. H. A rabbit model with acute throm-bo-embolic pulmonary hypertension created with echocardiography guidance // Ultrasound Med. Biol.- 2008.- Vol. 34.- P. 221-227.
- Ketabchi F., Ghofrani H. A., Schermuly R. T., Seeger W., Grimminger F., Egemnazarov B., Shid-Moosavi S. M., Dehghani G. A., Weissmann N., Sommer N. Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction // Respir. Res.- 2012.- Vol. 30.- P. 13-27.
- Физиология и патофизиология легочных сосудов: пер. с англ. / ред. Е. К. Уэйр, Дж. Т. Ривс.- М.: Медицина, 1995.- 672 с.
- Bach A. G., Nansalmaa B., Kranz J., Taute B. M., Wienke A., Schramm D., SurovA. CT pulmonary angiography findings that predict 30-day mortality in patients with acute pulmonary embolism // Eur. J. Radiol. - 2015.- Vol. 84.- P. 332-337.
- Watts J. A., Marchick M. R., Kline J. A. Right ventricular heart failure from pulmonary embolism: key distinctions from chronic pulmonary hypertension // J. Card. Fail.- 2010.- Vol. 16.- P. 250-259.
- Filho F. B., de Campos K. N., de Oliveira H. A., Fernandes J., Melo e Silva C., Gaio E., Parra E. R., de Carvalho P. H., Fernandes P. M. Hemodynamic Effects of Experimental Acute Right Ventricular Overload // Arq. Bras. Cardiol.- 2011.- Vol. 96.- P. 284-292.
- Kim Y. K., Shin W. J., Song J. G., Jun I. G., Kim H. Y., Seong S. H., Huh I. Y., Hwang G. S. Effect of right ventricular dysfunction on dynamic preload indices to predict a decrease in cardiac output after inferior vena cava clamping during liver transplantation // Transplant. Proc.- 2010.- Vol. 42.- P. 2585-2589.
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