Molecular genetic basis of malignant tumor heterogeneity


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Abstract

Molecular heterogeneity of oncological diseases is revealed to the greatest extent in the case of leucosis (the discovery of «Philadelphia chromosome», i.e. translocation between the 9th and 22nd chromosome). Molecular analysis has allowed defining several subtypes of breast cancer: (i) luminal A (clearly hormone-sensitive), (ii) luminal В (relatively hormone-sensitive), (iii) breast cancer with an upregulation of HER2/neu, (iv) basal-like cancer (frequent in patients with BRCA1 mutation and without HER 2, ER and PR expression). Molecular genetic cancer subtypes differ in their prognosis and responsiveness to various therapies. Many of the discovered growth factors have proved to be targets for successful therapy.

About the authors

V F Semiglazov

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

Член-корреспондент РАМН

E N Imyanitov

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

G A Dashyan

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

V St Semiglazov

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

E D Mazcko

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

V G Ivanov

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

A A Bojok

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

R M Paltyev

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

D A Voskresenskiy

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

E A Shamina

N. N. Petrov Institute of Oncology, St. Petersburg; I. P. Pavlov State Medical University

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Copyright (c) 2009 Semiglazov V.F., Imyanitov E.N., Dashyan G.A., Semiglazov V.S., Mazcko E.D., Ivanov V.G., Bojok A.A., Paltyev R.M., Voskresenskiy D.A., Shamina E.A.

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