Email this article EDITING THE BEHAVIOR OF EXPERIMENTAL ANIMALS MODULATED IN VITRO BY IMMUNE CELLS
- Authors: Knyazheva MA1, Serenko EV2, Karpovich GS2
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Affiliations:
- Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Novosibirsk
- Novosibirsk State Medical University, Novosibirsk
- Issue: Vol 19, No 1S (2019)
- Pages: 149-151
- Section: Articles
- URL: https://journals.rcsi.science/MAJ/article/view/19373
- ID: 19373
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Abstract
The aim of the study is to edit the hyperactive behavior in experiments using immunocyte transplantation using in vitro modules with neuroleptic functional activity. Materials and methods. Experimental model: male mice (CBAxC57Bl/6) F1 of three months of age with hyperactive behavior. Immune cells were treated with chlorpromazine in a test tube, injected intravenously into the recipient, in which the behavior parameters in the open field test and the cytokine content in the brain were determined by ELISA. Results. Transplantation of precision and neuroleptic components contained in recipient mice is accompanied by a decrease in the indices of research and motor components, as well as the levels of IL-1β, IL-6 and TNFα cytokines in the brain.
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##article.viewOnOriginalSite##About the authors
M A Knyazheva
Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, Novosibirsk
E V Serenko
Novosibirsk State Medical University, Novosibirsk
G S Karpovich
Novosibirsk State Medical University, Novosibirsk
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