Email this article Features of the dynamics of inflammation and apoptosis markers in patients with different acute post-stroke period
- Authors: Zozulya SA1, Otman IN1, Chukanova AS2, Klyushnik TP1
-
Affiliations:
- Mental Health Research Center, Moscow
- Pirogov Russian Research University, Moscow
- Issue: Vol 19, No 1S (2019)
- Pages: 126-129
- Section: Articles
- URL: https://journals.rcsi.science/MAJ/article/view/19361
- ID: 19361
Cite item
Full Text
Abstract
The purpose of this was to study the dynamics of markers of inflammation and apoptosis in the serum of patients with ischemic stroke in the early post-stroke period. Materials and methods. The study involved 22 patients (mean age 60 ± 5.5 years) with different dynamics of neurological symptoms in the acute post-stroke period. Patients were examined twice: on the 1st and 10th day of observation. Quantitative assessment of the severity of neurological deficit using ESS and NIHSS scales was carried. Enzymatic activity of leukocyte elastase, functional activity of a1-proteinase inhibitor, level of autoantibodies to MBP (inflammatory markers), as well as the content of p53 and Bcl-2 proteins (markers of apoptosis) were determined in serum. The control group consisted of 35 somatically healthy people of the appropriate age and sex. Results. Identified the different features of the spectrum of the analyzed markers of inflammation and apoptosis in patients with positive and negative dynamics of neurological symptoms in the acute period of ischemic stroke assessed according to the ESS and NIHSS scales. The observed clinical and biological relationships reflect the features of the course of the early post-stroke period and can be considered as possible predictors of the development trajectory of acute brain ischemia.
Full Text
##article.viewOnOriginalSite##About the authors
S A Zozulya
Mental Health Research Center, Moscow
I N Otman
Mental Health Research Center, Moscow
A S Chukanova
Pirogov Russian Research University, Moscow
T P Klyushnik
Mental Health Research Center, Moscow
References
- Скворцова В.И. Медицинская и социальная значимость ишемического инсульта // Качество жизни. Медицина. - 2004. - № 4(7). - С. 2-6. [Skvorcova VI. Medicinskaya i social’naya znachimost’ ishe¬micheskogo insul’ta. Kachestvo zhizni. Medicina. 2004;4(7):2-6. (In Russ.)]
- Arumugam TV, Baik S-H, Balaganapathy P, et al. Notch signaling and neuronal death in stroke. Prog Neurobiol. 2018;165-167:103-116. https://doi.org/10.1016/j.pneurobio.2018.03.002. Epub 2018 Mar 21.
- Jiang C, Kong W, Wang Y, et al. Changes in the cellular immune system and circulating inflammatory markers of stroke patients. Oncotarget. 2017;10(8(2)):3553-3567. https://doi.org/10.18632/oncotarget.12201.
- Доценко В.Л., Нешкова Е.А., Яровая Г.А. Выявление лейкоцитарной эластазы человека из комплекса с плазменным α1-протеиназным ингибитором по ее энзиматической активности с синтетическим субстратом // Вопр. Мед. Хим. - 1994. - № 40(3). - С. 20-25. [Docenko VL, Neshkova EA, Yarovaya GA. Vyyavlenie lejkocitarnoj ehlastazy cheloveka iz kompleksa s plazmennym α1-proteinaznym ingibitorom po eyo ehnzimaticheskoj aktivnosti s sinteticheskim substratom. Vopr. Med. Him. 1994;(40(3)):20-25. (In Russ.)]
- Нартикова В.Ф., Пасхина T.С. Унифицированный метод определения активности альфа1-антитрипсина и альфа-2-макроглобулина в сыворотке (плазме) крови человека // Вопр. Мед. Хим. - 1979. - № 25(4). - С. 494-499. [Nartikova VF, Paskhina TS. Unificirovannyj metod opredeleniya aktiv¬nosti alfa-1-antitripsina i alfa-2-makroglobulina v syvorotke (plazme) krovi cheloveka. Vopr. Med. Him. 1979;(25(4)):494-499. (In Russ.)]
- Клюшник Т.П., Андросова Л.В., Зозуля С.А., и др. Сравнительный анализ воспалительных маркеров при эндогенных и непсихотических психических расстройствах // Сибирский вестник психиатрии и наркологии. - 2018. - № 2(99). - С. 64-69. [Klyushnik TP, Androsova LV, Zozulya SA, et al. Sravnitel’nyj analiz vospalitel’nyh markerov pri ehndogennyh i nepsihoticheskih psihicheskih rasstrojstvah. Sibirskij vestnik psihiatrii i narkologii. 2018;(2(99)):64-69. (In Russ.)]
Supplementary files
