Email this article INFLAMM-AGING: THE HYPOTHESIS OF THE INFLAMMATION ROLE IN ALZHEIMER DISEASE PROGRESS
- Authors: Kventoy IM1,2,3, Linkova NS4,5, Diatlova AS4, Zuev VA4, Kventaia TV4
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Affiliations:
- D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg
- Saint Petersburg State University, Saint Petersburg
- Saint Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg
- Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg
- Academy of Postgraduate Education under FSBU FSCC of FMBA of Russia, Moscow
- Issue: Vol 19, No 1S (2019)
- Pages: 88-91
- Section: Articles
- URL: https://journals.rcsi.science/MAJ/article/view/19340
- ID: 19340
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Abstract
Inflamm-aging - the term, describes the development of chronic inflammation during aging without the infection pathology. It is supposed, that inflamm-aging is one of the reason of age-related pathology, partially, Alzheimer disease (AD). There were done comparative analysis of AD (Аβ42, τ-protein, р16) and inflammation (IL-6, TGFα, NF-kB) markers in hippocamp and blood lymphocytes in elderly and old people. It was shown, that expression of investigated signal molecules in hippocamp and lymphocytes of elderly and old AD people increased in comparison with people of control group (without neurodegenerative pathology). Thus, inflammation mediators play important role in AD pathogenesis and can be the potential target for neuropathology therapy.
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##article.viewOnOriginalSite##About the authors
I M Kventoy
D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg; Saint Petersburg State University, Saint Petersburg; Saint Petersburg Research Institute of Phthisiopulmonology, Saint Petersburg
N S Linkova
Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg; Academy of Postgraduate Education under FSBU FSCC of FMBA of Russia, Moscow
A S Diatlova
Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg
V A Zuev
Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg
T V Kventaia
Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg
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