Email this article MARKERS OF INFLAMMATION IN THE BLOOD PLASMA OF PATIENTS WITH FRONTOTEMPORAL DEMENTIA
- Authors: Androsova LV1, Zozulya SA1, Mikhailova NM1, Fedorova Y.B1, Klyushnik TP1
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Affiliations:
- Mental Health Research Center
- Issue: Vol 19, No 1S (2019)
- Pages: 10-12
- Section: Articles
- URL: https://journals.rcsi.science/MAJ/article/view/19295
- ID: 19295
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Abstract
The aim of this work was to identify several markers of inflammation in the blood of patients with frontotemporal dementia (FTD). 34 patients were surveyed with FTD. The control group consisted of 35 age- and sex- matched healthy people. Blood plasma was used for immunological studies. The enzymatic activity of leukocyte elastase (LE) and the functional activity of the α1-proteinase inhibitor (α1-PI) were determined by a spectrophotometric method, the concentration of interleukin-6 (IL-6) and C-reactive protein (CRP) were measured by ELISE. A statistically significant increase in α1-PI activity (p < 0.0001) was detected in patients with FTD; no difference from control was found for other indicators. There is a significant variation in all indicators, i.e. both increase and decrease of values compared to the control group. According to the level of LE activity, two immunophenotypes were identified. 73.5% of patients with FTD have an immunophenotype characteristic of patients with endogenous psychosis and 26.5% of patients have an immunophenotype similar to Alzheimer’s disease. The data obtained indicate the involvement of inflammatory reactions in the development of FTD and the heterogeneity of this disease as assed by immunological parameters.
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##article.viewOnOriginalSite##About the authors
L V Androsova
Mental Health Research Center
S A Zozulya
Mental Health Research Center
N M Mikhailova
Mental Health Research Center
Ya B Fedorova
Mental Health Research Center
T P Klyushnik
Mental Health Research Center
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