Email this article The specific activity of proteins involved in iron metabolism depends on compensation of type 2 diabetes mellitus
- Authors: Voynova I.V.1, Kostevich V.A.1, Elizarova A.Y.1, Karpenko M.N.1, Sokolov A.V.1,2
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Affiliations:
- Institute of Experimental Medicine
- Saint Petersburg State University
- Issue: Vol 19, No 2 (2019)
- Pages: 37-42
- Section: Original research
- URL: https://journals.rcsi.science/MAJ/article/view/16133
- DOI: https://doi.org/10.17816/MAJ19237-42
- ID: 16133
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Abstract
Objective. We aimed to analyze the alterations of activity of iron metabolism members i.e. ceruloplasmin (Cp) and transferrin (Tf), in relation to the percentage of glycated hemoglobin. The latter is one of biochemical criteria of chronic hyperglycemia compensation in case of type 2 diabetes mellitus.
Materials and methods. Concentration and activity of Cp and Tf, concentration of iron, copper and lipoprotein cholesterol were measured by biochemical methods in blood serum samples obtained from healthy donors and patients with type 2 diabetes mellitus divided in three groups according to glycated hemoglobin level.
Results. The significant decrease in serum copper, ferroxidase activity of Cp and iron-binding capacity of Tf, as well as an increase of Tf concentration, in groups with compensated and uncompensated type 2 diabetes mellitus was found.
Conclusion. Our data demonstrate a statistical link between the degree of type 2 diabetes mellitus compensation and alteration of iron metabolism members’ activity. Thus, an increase of hyperglycemia is associated with a decrease of both Cp ferroxidase activity and the degree of Tf saturation with iron. These alterations may explain the efficiency of treatment with iron chelators of such type 2 diabetes mellitus complications as trophic ulcers. The said disease condition is directly connected with the changes in iron efflux.
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##article.viewOnOriginalSite##About the authors
Irina V. Voynova
Institute of Experimental Medicine
Email: iravoynova@mail.ru
PhD student, Research fellow of the Department of Molecular Genetics
Russian Federation, Saint PetersburgValeria A. Kostevich
Institute of Experimental Medicine
Email: hfa-2005@yandex.ru
ORCID iD: 0000-0002-1405-1322
SPIN-code: 2726-2921
PhD (Biology), Senior Researcher of the Department of Molecular Genetics
Russian Federation, Saint PetersburgAnna Yu. Elizarova
Institute of Experimental Medicine
Email: anechka_v@list.ru
SPIN-code: 3059-4381
PhD student, Research fellow of the Department of Molecular Genetics
Russian Federation, Saint PetersburgMarina N. Karpenko
Institute of Experimental Medicine
Email: mnkarpenko@mail.ru
ORCID iD: 0000-0002-1082-0059
SPIN-code: 6098-2715
PhD (Biology), Senior Researcher of The Pavlov Department of Physiology
Russian Federation, Saint PetersburgAlexey V. Sokolov
Institute of Experimental Medicine; Saint Petersburg State University
Author for correspondence.
Email: biochemsokolov@gmail.com
ORCID iD: 0000-0001-9033-0537
SPIN-code: 7427-7395
Doctor of Biological Sciences, Head of the Laboratory of Biochemical Genetics of the Department of Molecular Genetics; Professor of Chair of Fundamental Problems of Medicine and Medical Technology
Russian Federation, Saint PetersburgReferences
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