Email this article The reciprocal character of the muscarinic and nicotinic cholinergic mechanisms interaction in the systemic hemodynamics regulation
- Authors: Loseѵ NA1, Evlakhov VI1, Shalkovskaya LN2
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Affiliations:
- Institute of Experimental Medicine of the North-West Department Russian Acad. Med. Sci., St. Petersburg
- I. P. Pavlov State Medical University, St. Petersburg
- Issue: Vol 11, No 2 (2011)
- Pages: 33-41
- Section: Articles
- URL: https://journals.rcsi.science/MAJ/article/view/10002
- DOI: https://doi.org/10.17816/MAJ11233-41
- ID: 10002
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Abstract
On anesthetized cats following M-cholinoreceptors blockade acetylcholine injection caused, in contrast with intact animals, the increasing of the arterial pressure, cardiac output, total peripheral resistance, heart rate and myocardial contractility. After acetylcholine injection in the condition of the N-cholinoreceptors blockade the systemic hemodynamic parameters decreased more, comparing with the intact animals. Thus, N-mimetic effects of acetylcholine are augmented following M-cholinoreceptors blockade; meanwhile M-mimetic effects of acetylcholine on the heart and vessels are increased following N-cholinoreceptors blockade. After the blockade of muscarinic or nicotinic receptors adrenaline injection caused more evaluated increasing of the systemic hemodynamic parameters comparing with intact animals. However, if we injected adrenalin in cats following M-cholinoreceptors blockade combined with inhibition of acetylcholinesterase by proserine, the systemic hemodynamic parameters increased more, comparing with animals with only M-cholinoreceptors blockade. If we injected adrenalin in cats following N-cholinoreceptors blockade combined with inhibition of acetylcholinesterase, the systemic hemodynamic parameters increased less, than in animals with only N-cholinoreceptors blockade. Thus, we concluded that there is reciprocal interaction between muscarininc and nicotinic cholinergic mechanisms in the processes of the nervous regulation of the systemic circulation.
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##article.viewOnOriginalSite##About the authors
N A Loseѵ
Institute of Experimental Medicine of the North-West Department Russian Acad. Med. Sci., St. Petersburg
Email: iem@iem.spb.ru
Санкт-Петербург, 197376, ул. Академика Павлова, 12
V I Evlakhov
Institute of Experimental Medicine of the North-West Department Russian Acad. Med. Sci., St. PetersburgСанкт-Петербург, 197376, ул. Академика Павлова, 12
L N Shalkovskaya
I. P. Pavlov State Medical University, St. PetersburgСанкт-Петербург, 197022, ул. Л. Толстого, 6/8
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