电邮这篇文章 Role of preoperative stress in Wistar rats at myocardial injury during extracardiac surgery
- 作者: Kondashevskaya M.V.1, Manukhina E.B.2,3, Aleksankina V.V.1, Artemyeva K.A.1, Kaktursky L.V.1
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隶属关系:
- Avtsyn Research Institute of Human Morphology Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of Surgery”
- Federal State Budgetary Scientific Institution “Research Institute of General Pathology and Pathophysiology”
- University of North Texas Health Science Center
- 期: 卷 523, 编号 1 (2025)
- 页面: 389-396
- 栏目: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/330160
- DOI: https://doi.org/10.31857/S2686738925040024
- ID: 330160
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详细
The work was performed on 4 groups of old Wistar rats: anesthesia only (An), noncardiac surgery (NS), extracardiac surgery (ES) with prior stress for 5 days (SNS), and intact animals used as a control. As evident from the absence of increases in proinflammatory cytokines and C-reactive protein 10 days after the surgery, the animals did not have any inflammation. The presence of stress was judged by the highest level of corticosterone in the SNS rats. These animals had myocardial injury after NS (MINS) indicated by structural and metabolic disorders, as well as an increase in the blood concentration of high-sensitive cardiac troponin I (hs-cTnI). Despite the fact that the rats in the An and NS groups had some ischemic zones in the myocardium, they did not develop MINS, since there was no oxidant-antioxidant imbalance and, most importantly, no increase in hs-cTnI. This study showed for the first time that “simple” aseptic noncardiac surgery in combination with preoperative stress can induce MINS in healthy Wistar rats. It is proposed to use a decrease in the level of superoxide dismutase as an additional biomarker of MINS.
作者简介
M. Kondashevskaya
Avtsyn Research Institute of Human Morphology Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of Surgery”
Email: marivladiko@mail.ru
Moscow, Russian Federation
E. Manukhina
Federal State Budgetary Scientific Institution “Research Institute of General Pathology and Pathophysiology”; University of North Texas Health Science Center
Email: marivladiko@mail.ru
Moscow, Russian Federation; 3500 Camp Bowie Blvd, Fort Worth 76107, USA
V. Aleksankina
Avtsyn Research Institute of Human Morphology Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of Surgery”
Email: marivladiko@mail.ru
Moscow, Russian Federation
K. Artemyeva
Avtsyn Research Institute of Human Morphology Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of Surgery”
Email: marivladiko@mail.ru
Moscow, Russian Federation
L. Kaktursky
Avtsyn Research Institute of Human Morphology Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of Surgery”
编辑信件的主要联系方式.
Email: marivladiko@mail.ru
Moscow, Russian Federation
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