SYNERGISTIC EFFECT OF THE COMBINED ACTION OF TARGETED AND PHOTODYNAMIC THERAPY ON HER2-POSITIVE BREAST CANCER
- 作者: Balalaeva I.1, Krylova L.1, Karpova M.1, Shulga A.2, Konovalova E.2, Guryev E.1, Deyev S.2,3
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隶属关系:
- Lobachevsky State University of Nizhny Novgorod
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- I.M. Sechenov First Moscow State Medical University
- 期: 卷 508, 编号 1 (2023)
- 页面: 48-52
- 栏目: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135676
- DOI: https://doi.org/10.31857/S268673892270007X
- EDN: https://elibrary.ru/MUGOWP
- ID: 135676
如何引用文章
详细
Development of combined schemes for the treatment of oncological diseases is a promising strategy to improve the effectiveness of antitumor therapy. This paper shows the fundamental possibility of multiplying the antitumor effect by combining targeted and photodynamic therapy. It has been demonstrated that sequential treatment of HER-2 positive breast cancer cells with the targeted toxin DARPin-LoPE and the photoactive compound Photodithazine leads to a synergistic enhancement of their effect. In the future, this approach is intended to achieve the maximum therapeutic effect while minimizing the risks of negative side effects.
作者简介
I. Balalaeva
Lobachevsky State University of Nizhny Novgorod
编辑信件的主要联系方式.
Email: irin-b@mail.ru
Russian Federation, Nizhny Novgorod
L. Krylova
Lobachevsky State University of Nizhny Novgorod
Email: biomem@mail.ru
Russian Federation, Nizhny Novgorod
M. Karpova
Lobachevsky State University of Nizhny Novgorod
Email: biomem@mail.ru
Russian Federation, Nizhny Novgorod
A. Shulga
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: biomem@mail.ru
Russian Federation, Moscow
E. Konovalova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: biomem@mail.ru
Russian Federation, Moscow
E. Guryev
Lobachevsky State University of Nizhny Novgorod
Email: biomem@mail.ru
Russian Federation, Nizhny Novgorod
S. Deyev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; I.M. Sechenov First Moscow State Medical University
编辑信件的主要联系方式.
Email: biomem@mail.ru
Russian Federation, Moscow; Russian Federation, Moscow
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