Ontogeny of the epileptic system in rats of the Krushinsky–Molodkina line with genetically determined audiogenic epilepsy

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Abstract

The development of convulsive proneness of audiogenic epilepsy (AE) and phenotype manifestations of epileptic activity in rats of the Krushinsky – Molodkina (KM) strain, proceeds in parallel with the appearance of seizure EEG patterns followed in this investigation from the age of 2 months age up to 7 months (both in КМ rats). The latencies of the seizure onset reduced with age while the intensity of convulsive seizures increased. In background EEG (no exposure to sound) of KM rats two types of epileptiform discharges (ED) were identified. The first type had the form of high-amplitude generalized “packs” of waves, with animal shuddering. The second type of ED had the form of a generalized non-seizure absence-like “spike-wave” discharges with animal freezing. The duration of single absence-like discharges increased with age. The parallel age-related changes were found between the increase in severity of AE seizure and the increase of generalized absence-like discharges numbers in the forebrain EEG of KM rats, which evidence the development of epileptic system in this strain.

About the authors

S. A. Litvinova

Federal State Budgetary Scientific Institution “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”

Email: litvinova_sa@academpharm.ru
Moscow, Russian Federation

A. A. Yakovleva

Federal State Budgetary Scientific Institution “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”

Moscow, Russian Federation

T. A. Voronina

Federal State Budgetary Scientific Institution “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”

Moscow, Russian Federation

N. S. Gladysheva

Federal State Budgetary Scientific Institution “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”

Moscow, Russian Federation

V. V. Radontseva

Federal State Budgetary Scientific Institution “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”

Moscow, Russian Federation

N. M. Surina

Faculty of Biology, Moscow State University M.V. Lomonosova

Moscow, Russian Federation

I. I. Poletaeva

Faculty of Biology, Moscow State University M.V. Lomonosova

Moscow, Russian Federation

I. B. Fedotova

Faculty of Biology, Moscow State University M.V. Lomonosova

Moscow, Russian Federation

A. D. Durnev

Federal State Budgetary Scientific Institution “Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies”

Moscow, Russian Federation

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