Enviar artigo por via de e-mail Contact inhibition of proliferation is accompanied by expression of the PHF10D subunit of the chromatin remodeling complex PBAF in mouse and human cell lines
- Autores: Simonov Y.1, Tatarskiy V.2, Georgieva S.1, Soshnikova N.1,3
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Afiliações:
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Institute of Gene Biology, Russian Academy of Sciences
- Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Edição: Volume 514, Nº 1 (2024)
- Páginas: 111-116
- Seção: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/258957
- DOI: https://doi.org/10.31857/S2686738924010211
- EDN: https://elibrary.ru/KDLLXE
- ID: 258957
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Resumo
PHF10 is a subunit of the PBAF complex, which regulates the expression of many genes in developing and maturing organisms. PHF10 has four isoforms that differ in domain structure. The PHF10A isoform, containing a DPF domain at the C-terminus and 46 amino acids at the N-terminus, is necessary for the expression of gene proliferation; the functions of the other isoforms are less studied. In this work, we have established that upon contact inhibition of mouse and human cell proliferation caused by the establishment of a tight junction and adherence junction between cells, the expression of the PHF10A isoform stops and instead the PHF10D isoform is expressed, which does not contain DPF-domain and N-terminal sequence. The function of the PHF10D isoform may be associated with the establishment of intercellular contacts.
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Sobre autores
Yu. Simonov
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: so2615nat@gmail.com
Department of Transcription Factors
Rússia, MoscowV. Tatarskiy
Institute of Gene Biology, Russian Academy of Sciences
Email: so2615nat@gmail.com
Rússia, Moscow
S. Georgieva
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Email: so2615nat@gmail.com
academician of the RAS, Department of Transcription Factors
Rússia, MoscowN. Soshnikova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Autor responsável pela correspondência
Email: so2615nat@gmail.com
Department of Transcription Factors
Rússia, Moscow; MoscowBibliografia
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