THE ROLE OF NEUROHUMORAL IMBALANCE AT POST-TRAUMATIC STRESS DISORDER IN THE ANTITUMOR IMMUNE RESPONSE. EXPERIMENTAL STUDY
- Autores: Kondashevskaya M.1, Artemieva K.1, Aleksankina V.1, Kudelkina V.1, Kosyreva A.1, Areshidze D.1, Kozlova M.1, Mikhaleva L.1
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Afiliações:
- Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
- Edição: Volume 511, Nº 1 (2023)
- Páginas: 333-339
- Seção: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135641
- DOI: https://doi.org/10.31857/S2686738923600127
- EDN: https://elibrary.ru/IYYKGS
- ID: 135641
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Resumo
The aim of the study was to investigate the growth and development of B16 melanoma in mature male C57Black/6 mice with a post-traumatic stress disorder (PTSD) model. Behavioral, immunohistochemical, morphometric methods, enzyme immunoassay were used. A forced decrease in the level of corticosterone, which is characteristic for PTSD, was established, followed by an intensification of the production of increased concentrations of pro-inflammatory interleukins by the cells of the immune system and, at the same time, a decrease in the secretion of anti-inflammatory cytokines. Priority data were obtained: the neurohumoral imbalance that develops in PTSD is a limiting factor to the growth of B16 melanoma, at least at the initial stages of the oncological process.
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Sobre autores
M. Kondashevskaya
Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
Autor responsável pela correspondência
Email: marivladiko@mail.ru
Russian Federation, Moscow
K. Artemieva
Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
Email: marivladiko@mail.ru
Russian Federation, Moscow
V. Aleksankina
Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
Email: marivladiko@mail.ru
Russian Federation, Moscow
V. Kudelkina
Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
Email: marivladiko@mail.ru
Russian Federation, Moscow
A. Kosyreva
Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
Email: marivladiko@mail.ru
Russian Federation, Moscow
D. Areshidze
Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
Email: marivladiko@mail.ru
Russian Federation, Moscow
M. Kozlova
Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
Email: marivladiko@mail.ru
Russian Federation, Moscow
L. Mikhaleva
Avtsyn Research Institute of human morphology of Federal State Budgetary Scientific Institution “Petrovsky National Research Centre of surgery”
Email: marivladiko@mail.ru
Russian Federation, Moscow
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