电邮这篇文章 The Impact of the Protein-Opener of the Desmoglein Contacts on the Accumulation of Targeted Nanoagents in HER2-Positive Solid Tumors
- 作者: Proshkina G.M.1, Shramova E.I.1,2, Mirkasymov A.B.1,2, Serova E.V.1, Deyev S.M.1,2,3
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隶属关系:
- M.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry RAS
- Moscow Institute of Engineering Physics, National Research Nuclear University “MEPhI”
- Ogarev National Research Mordovian State University
- 期: 卷 523, 编号 1 (2025)
- 页面: 469-473
- 栏目: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/330173
- DOI: https://doi.org/10.31857/S2686738925040156
- ID: 330173
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详细
Despite significant progress in oncotherapy, oncological diseases continue to pose a serious problem for public health. The limited penetration of nanoscale therapeutic drugs into solid tumors, due to the presence of tight intercellular junctions, does not allow achieving therapeutically effective drug concentrations in distal tumor cells, which leads to the appearenceof drug resistance. In this work, to increase the accumulation of HER2-specific small gold nanoparticles (DARPin-AuNPs) in solid tumors, the use of these particles in combination with the protein-opener of desmoglein junctions JO-4 is proposed. A quantitative assessment of gold biodistribution in mice showed that co-administration of DARPin-AuNP/JO-4 in vivo increased particle accumulation in tumors by approximately 2.5-fold compared to administration of DARPin-AuNP alone.
作者简介
G. Proshkina
M.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: gmb@ibch.ru
Moscow, Russian Federation
E. Shramova
M.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry RAS; Moscow Institute of Engineering Physics, National Research Nuclear University “MEPhI”
Email: gmb@ibch.ru
Moscow, Russian Federation; Moscow, Russian Federation
A. Mirkasymov
M.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry RAS; Moscow Institute of Engineering Physics, National Research Nuclear University “MEPhI”
Email: gmb@ibch.ru
Moscow, Russian Federation; Moscow, Russian Federation
E. Serova
M.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry RAS
Email: gmb@ibch.ru
Moscow, Russian Federation
S. Deyev
M.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry RAS; Moscow Institute of Engineering Physics, National Research Nuclear University “MEPhI”; Ogarev National Research Mordovian State University
编辑信件的主要联系方式.
Email: gmb@ibch.ru
Moscow, Russian Federation; Moscow, Russian Federation; Saransk, Russian Federation
参考
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